Ethoxy(methylaminomethyl)phosphinic acid | 137734-64-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: Ethoxy(methylaminomethyl)phosphinic acid
• 英文别名: ethoxy(methylaminomethyl)phosphinic acid
• CAS: 137734-64-6
• 化学式: C₄H₁₂NO₃P
• 分子量: 153.118
• InChiKey: SNCFNDWULSIASU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.3
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  氯甲酸-9-芴基甲酯 、 Ethoxy(methylaminomethyl)phosphinic acid 在 三乙胺 作用下， 以 氯仿 为溶剂， 反应 20.0h， 以83 mg的产率得到{[(9-H-fluoren-9-ylmethoxycarbonyl)methylamino]methyl}phosphonic acid monoethyl ester
  参考文献：
  名称：

  Intramolecular Hydrogen-Bond Participation in Phosphonylammonium Salt Formation

  摘要：

  A series of phosphonochloridates and phosphonyl dichlorides were prepared, and their reactivity with triethylamine has been investigated using P-31 NMR spectroscopy, Taken together these studies provide evidence that an intramolecular hydrogen-bond is required for phosphonylammonium salt formation to render the phosphorus more electron-deficient.

  DOI：

  10.1021/ol0066330
• 作为产物：
  描述：

  [(benzyloxycarbonylmethylamino)methyl]phosphonic acid monoethyl ester 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 反应 5.0h， 生成 Ethoxy(methylaminomethyl)phosphinic acid
  参考文献：
  名称：

  Intramolecular Hydrogen-Bond Participation in Phosphonylammonium Salt Formation

  摘要：

  A series of phosphonochloridates and phosphonyl dichlorides were prepared, and their reactivity with triethylamine has been investigated using P-31 NMR spectroscopy, Taken together these studies provide evidence that an intramolecular hydrogen-bond is required for phosphonylammonium salt formation to render the phosphorus more electron-deficient.

  DOI：

  10.1021/ol0066330

文献信息

• Maier, Ludwig, Phosphorus, Sulfur and Silicon and the Related Elements, 1991, vol. 62, # 1.4, p. 29 - 34
  作者：Maier, Ludwig

  DOI：——

  日期：——
• Intramolecular Hydrogen-Bond Participation in Phosphonylammonium Salt Formation
  作者：Amos B. Smith、Laurent Ducry、R. Michael Corbett、Ralph Hirschmann

  DOI：10.1021/ol0066330

  日期：2000.11.1

  A series of phosphonochloridates and phosphonyl dichlorides were prepared, and their reactivity with triethylamine has been investigated using P-31 NMR spectroscopy, Taken together these studies provide evidence that an intramolecular hydrogen-bond is required for phosphonylammonium salt formation to render the phosphorus more electron-deficient.