N-isopropylaminopentane | 36343-02-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-isopropylaminopentane
• 英文别名: isopropyl-pentyl-amine；1-Isopropylamino-pentan；Isopropyl-pentyl-amin；1-Pentanamine, N-(1-methylethyl)-；N-propan-2-ylpentan-1-amine
• CAS: 36343-02-9
• 化学式: C₈H₁₉N
• mdl: MFCD09813342
• 分子量: 129.246
• InChiKey: QCWXZFZXEGTLOV-UHFFFAOYSA-N

物化性质

• 沸点：
  146 °C
• 密度：
  0.761±0.06 g/cm3(Predicted)
• 保留指数：
  893

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-isopropylaminopentane 在 乙醚 、 氨 、 水 、 镍 、 sodium hydrogensulfite 、 苯酚 作用下， 生成 N'-(6-chloro-2-methoxy-acridin-9-yl)-N-isopropyl-N-pentyl-ethylenediamine
  参考文献：
  名称：

  2-甲氧基-6-氯-9-（N-取代的氨基）-啶; 衍生自环状仲胺的化合物。

  摘要：

  DOI：

  10.1021/ja01214a012

文献信息

• [EN] CXCR3 RECEPTOR AGONISTS<br/>[FR] AGONISTES DU RÉCEPTEUR CXCR3
  申请人：CELGENE INT II SARL

  公开号：WO2018045246A1

  公开（公告）日：2018-03-08

  Compounds are provided having the structure of the following Formula I: where R, R1, R2, R3a and R3b are as defined herein. Pharmaceutical compositions comprising such compounds, as well as methods related to their manufacture and use, are also provided.

  提供具有以下式I结构的化合物：其中R、R1、R2、R3a和R3b如本文所述定义。还提供了包含这些化合物的药物组合物，以及与它们的制造和使用相关的方法。
• Gambogenic Acid Derivatives, Preparation Method and Application Thereof
  申请人：Ninth People's Hospital, School Medicine Shanghai Jiao Tong University

  公开号：US20140309418A1

  公开（公告）日：2014-10-16

  Gambogenic acid derivatives having a structure shown as Formula (I) or (II), salts, preparation method and application thereof in the treatment of tumor. Compared with gambogenic acid, the gambogenic acid derivatives exhibit more potent anti-tumor activities.

  具有如下式(I)或(II)结构的甘宝生酸衍生物，盐，其制备方法以及在肿瘤治疗中的应用。与甘宝生酸相比，甘宝生酸衍生物表现出更强的抗肿瘤活性。
• PLATINUM COMPOUND HAVING AMINO OR ALKYLAMINO-CONTAINING SUCCINIC ACID DERIVATIVES AS LEAVING GROUP, PREPARTION METHOD THEREOF, AND USE THEREOF
  申请人：BEIJING FSWELCOME TECHNOLOGY DEVELOPMENT CO., LTD.

  公开号：US20140349985A1

  公开（公告）日：2014-11-27

  Disclosed are a category of platinum compounds having amino- or alkylamino-containing succinato derivatives as leaving group, or pharmaceutically acceptable salts thereof, preparation method thereof, and medicinal compositions containing the compounds. Also disclosed is a use of the compounds in treating cell proliferative diseases, especially cancers. The platinum compounds of the present invention have high water solubility and small toxic side effect.

  本发明揭示了一类铂化合物，其具有氨基或烷基氨基含有琥珀酸酯衍生物作为脱离基团，或其药用可接受的盐，以及其制备方法，以及含有这些化合物的药物组合物。本发明还揭示了这些化合物在治疗细胞增殖性疾病，特别是癌症方面的用途。本发明的铂化合物具有高水溶性和小毒副作用。
• METHOD FOR PREPARING 4-ISOPROPYLAMINO-1-BUTANOL
  申请人：SEASONS BIOTECHNOLOGY (TAIZHOU) CO., LTD.

  公开号：US20180029973A1

  公开（公告）日：2018-02-01

  The present invention relates to a preparation method of 4-isopropylamino-1-butanol, in which using cheap and readily available tetrahydrofuran and acetic acid solution of hydrogen bromide as starting materials to prepare a novel intermediate of 4-isopropylamino-1-acetoxyl butane and further obtain the target product. The present invention has advantages of convenient process operations, mild reaction conditions, economical and environment-friendly benefits, and suitability for industrial production to obtain the product with high purity and high yield.

  本发明涉及一种4-异丙氨基-1-丁醇的制备方法，其中使用廉价且易得的四氢呋喃和溴化氢乙酸溶液作为起始原料，制备4-异丙氨基-1-乙酰氧基丁烷的新型中间体，进而获得目标产品。本发明具有操作方便、反应条件温和、经济环保、适合工业生产以获得高纯度和高收率产品的优点。
• Ionic Liquids for Separation of Olefin-Paraffin Mixtures
  申请人：Dai Sheng

  公开号：US20110015461A1

  公开（公告）日：2011-01-20

  The invention is directed to an ionic liquid comprising (i) a cationic portion containing a complex of a silver (I) ion and one or more neutral ligands selected from organoamides, organoamines, olefins, and organonitriles, and (ii) an anionic portion having the chemical formula wherein m and n are independently 0 or an integer of 1 or above, and p is 0 or 1, provided that when p is 0, the group —N—SO 2 —(CF 2 ) n CF 3 subtended by p is replaced with an oxide atom connected to the shown sulfur atom. The invention is also directed to a method for separating an olefin from an olefin-paraffin mixture by passing the mixture through a layer of the ionic liquid described above.

  该发明涉及一种离子液体，包括（i）含有银（I）离子的阳离子部分，该离子与来自有机酰胺、有机胺、烯烃和有机腈中选择的一个或多个中性配体形成的络合物，以及（ii）具有化学式的阴离子部分，其中m和n独立地为0或大于1的整数，p为0或1，但当p为0时，由p支撑的基团—N—SO2—(CF2)nCF3将被连接到所示硫原子的氧原子替代。该发明还涉及一种从烯烃烷烃混合物中分离烯烃的方法，通过将混合物经过上述离子液体的一层来实现。