6-Aminobenzonorbornen | 35391-92-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 6-Aminobenzonorbornen
• 英文别名: 5-Amino-benzonorbornene；tricyclo[6.2.1.02,7]undeca-2(7),3,5-trien-4-amine
• CAS: 35391-92-5
• 化学式: C₁₁H₁₃N
• 分子量: 159.231
• InChiKey: OUDDUXOVAYIVED-UHFFFAOYSA-N

物化性质

• 沸点：
  295.2±29.0 °C(Predicted)
• 密度：
  1.159±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  硫光气 、 6-Aminobenzonorbornen 、 1-萘酚钠 生成
  参考文献：
  名称：

  Melloni; Metelli; Vecchietti, European Journal of Medicinal Chemistry, 1974, vol. 9, # 1, p. 26 - 31

  摘要：

  DOI：
• 作为产物：
  描述：

  5-Nitro-benzonorbornadiene 在 镍 、 钯 作用下， 以 甲醇 为溶剂， 以to form the 5-amino-benzonorbornene (D)的产率得到6-Aminobenzonorbornen
  参考文献：
  名称：

  PROCESS FOR THE PRODUCTION OF AROMATIC AMINDES IN THE PRESENCE OF A PALLADIUM COMPLEX COMPRISING A FERROCENYL BIPHOSPHINE LIGAND

  摘要：

  本发明涉及一种制备式（I）化合物的方法，其中R1为1,3-二甲基丁基、1,3,3-三甲基丁基或A1基团，其中R3、R4和R5各自独立地为氢或C1-C4烷基；R2为氢；或者R1和R2一起形成A2基团，其中R6和R7各自独立地为氢或C1-C4烷基；或者R1和R2一起形成A3基团，其中R5和R9各自独立地为氢或C1-C4烷基；其中化合物式（II）其中R1和R2如式（I）所定义，X为溴或氯，在碱和至少一种钯配合物催化剂的存在下与氨反应，其中钯配合物包括至少一种二茂铁双膦配体。

  公开号：

  US20100256417A1

文献信息

• Process for the production of amines
  申请人：Syngenta Participations AG

  公开号：EP2014642A1

  公开（公告）日：2009-01-14

  The present invention relates to a process for the preparation of compounds of formula I wherein R1 is C6-C7alkyl or a group A1 wherein R2, R3 and R4 are each independently of the others hydrogen or C1-C4alkyl; wherein a compound of formula II wherein R1 is as defined for formula I and X is bromine or chlorine, is reacted with urea in the presence of a base and a catalytic amount of at least one palladium complex compound, wherein the palladium complex compound comprises at least one ferrocenyl-biphosphine ligand.

  本发明涉及一种制备I式化合物的方法，其中R1为C6-C7烷基或A1基团，R2、R3和R4各自独立地为氢或C1-C4烷基；其中，II式化合物（其中R1如I式定义，X为溴或氯）在碱和至少一种钯配合物催化剂的存在下与尿素反应，所述钯配合物包括至少一种二茂铁双膦配体。
• PROCESS FOR THE PREPARATION OF AMINES
  申请人：Tobler Hans

  公开号：US20090221856A1

  公开（公告）日：2009-09-03

  The present invention relates to a novel a process for the preparation of the compound of the general formula (I), wherein R 1 and R 2 are independently H or C 1-6 alkyl, which comprises treating with a reducing agent either a compound of the general formula (II), wherein R 1 and R 2 have the meanings given for the compound of the formula (I), R 3 is H or C 1-4 alkyl and Ph is phenyl, or a compound of the general formula (III), wherein R 1 , R 2 , R 3 and Ph have the meanings given for the compound of the formula (II), the reducing agent being effective to cleave the benzyl moiety Ph-CH(R 3 )— from the benzylamino moiety PhCH(R 3 )NH— in the compound of the formula (II) or in the compound of the formula (III) to leave an amino group and, in addition, in the case of the compound of the formula (III), to reduce both the 2,3-double bond and the double bond joining the R 1 R 2 C— moiety to the 9-position of the benzonorbornene ring to single bonds. It also relates to processes for the preparation of the compounds (II) and (III) and their precursors and to the compounds (II) and (III) themselves and certain of their precursors, which are novel compounds. The compounds (I) are useful for the preparation of various fungicidal heterocyclyl-carboxylic acid benzonorbornen-5-yl-amides.

  本发明涉及一种制备通式（I）化合物的新型方法，其中R1和R2独立地表示H或C1-6烷基，包括以下步骤：使用还原剂处理通式（II）化合物或通式（III）化合物，其中R1和R2具有通式（I）化合物中所给定的含义，R3为H或C1-4烷基，Ph为苯基，所述还原剂能够从通式（II）化合物或通式（III）化合物的苄基Ph-CH（R3）中切除苄基PhCH（R3）NH-，以留下氨基，并且在通式（III）化合物的情况下，还能够将2,3-双键和连接R1R2C-基团到苯并[2.2.1]环庚烯环的9位的双键还原为单键。本发明还涉及制备化合物（II）和（III）及其前体的方法，以及化合物（II）和（III）本身及其某些前体，这些是新型化合物。通式（I）化合物可用于制备各种杀真菌的杂环羧酸苯并[2.2.1]环庚烯-5-基酰胺。
• Process for the preparation of amines
  申请人：Syngenta Crop Protection, Inc.

  公开号：US07781615B2

  公开（公告）日：2010-08-24

  The present invention relates to a novel a process for the preparation of the compound of the general formula (I), wherein R1 and R2 are independently H or C1-6 alkyl, which comprises treating with a reducing agent either a compound of the general formula (II), wherein R1 and R2 have the meanings given for the compound of the formula (I), R3 is H or C1-4alkyl and Ph is phenyl, or a compound of the general formula (III), wherein R1, R2, R3 and Ph have the meanings given for the compound of the formula (II), the reducing agent being effective to cleave the benzyl moiety Ph-CH(R3)— from the benzylamino moiety PhCH(R3)NH— in the compound of the formula (II) or in the compound of the formula (III) to leave an amino group and, in addition, in the case of the compound of the formula (III), to reduce both the 2,3-double bond and the double bond joining the R1R2C— moiety to the 9-position of the benzonorbornene ring to single bonds. It also relates to processes for the preparation of the compounds (II) and (III) and their precursors and to the compounds (II) and (III) themselves and certain of their precursors, which are novel compounds. The compounds (I) are useful for the preparation of various fungicidal heterocyclyl-carboxylic acid benzonorbornen-5-yl-amides.

  本发明涉及一种新颖的制备通式（I）化合物的方法，其中R1和R2独立地为H或C1-6烷基，该方法包括用还原剂处理通式（II）化合物或通式（III）化合物，其中R1和R2具有通式（I）化合物中所给出的含义，R3为H或C1-4烷基，Ph为苯基，该还原剂能够从通式（II）化合物或通式（III）化合物的苄基Ph-CH（R3）-中裂解苄胺基PhCH（R3）NH-，以留下氨基，并且在通式（III）化合物的情况下，还可以将连接R1R2C-基团与苯环莽环烷环的9位的双键以及2,3-双键还原为单键。本发明还涉及制备化合物（II）和（III）及其前体的方法，以及化合物（II）和（III）本身及其某些前体，这些是新的化合物。通式（I）化合物可用于制备各种杀真菌的杂环羧酸苯并莽烯-5-基酰胺。
• PROCESS FOR THE PRODUCTION OF AMIDES
  申请人：Tobler Hans

  公开号：US20120065239A1

  公开（公告）日：2012-03-15

  The present invention relates to a process for the preparation of compounds of formula I wherein R 1 and R 2 are each independently of the other hydrogen or C 1 -C 5 alkyl and R 3 is CF 3 or CF 2 H, by a) reaction of a compound of formula II wherein R 1 and R 2 are as defined for formula I, with at least one reducing agent to form a compound of formula wherein R 1 and R 2 are as defined for formula I, and b) reaction of that compound with at least one reducing agent to form a compound of formula IV wherein R 1 and R 2 are as defined for formula I, and (c) reaction of that compound with a compound of formula V wherein Q is chlorine, fluorine, bromine, iodine, hydroxy or C 1 -C 6 alkoxy and R 3 is as defined for formula I, to form the compound of formula I; and to novel intermediates for use in that process.

  本发明涉及一种制备式I化合物的方法，其中R1和R2分别独立地为氢或C1-C5烷基，R3为CF3或CF2H，包括以下步骤： a）将式II化合物与至少一种还原剂反应，形成式III化合物，其中R1和R2如式I所定义； b）将该化合物与至少一种还原剂反应，形成式IV化合物，其中R1和R2如式I所定义； c）将该化合物与式V化合物反应，其中Q为氯、氟、溴、碘、羟基或C1-C6烷氧基，R3如式I所定义，形成式I化合物； 本发明还涉及用于该过程的新型中间体。
• New crystal form of a pyrazole fungicide
  申请人：Syngenta Participations AG.

  公开号：EP2253623A1

  公开（公告）日：2010-11-24

  The present invention relates to Crystal modification B of syn-3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (9-isopropyl-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-yl)-amide.

  本发明涉及 syn-3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (9-isopropyl-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-yl)-amide 的晶体修饰 B。