3-chloro-N-(1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzamide | 1421609-40-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-chloro-N-(1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzamide
• 英文别名: 3-chloro-N-(1,4-dioxonaphthalen-2-yl)benzamide
• CAS: 1421609-40-6
• 化学式: C₁₇H₁₀ClNO₃
• 分子量: 311.724
• InChiKey: NAOWYQYRMWPUTN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,4-萘醌 在 sodium azide 、 sodium hydride 、 溶剂黄146 作用下， 以 四氢呋喃 、 水 、 mineral oil 为溶剂， 反应 6.08h， 生成 3-chloro-N-(1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzamide
  参考文献：
  名称：

  [EN] COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISEASES OR INJURY
  [FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT DE MALADIES OU DE LÉSIONS NEUROLOGIQUES

  摘要：

  提供了用于治疗神经系统疾病或损伤的化合物，包括神经退行性疾病、中风、创伤、癫痫、急性和慢性肾脏损伤、糖尿病和/或癫痫。在某些实施例中，提供了维生素K的衍生物。

  公开号：

  WO2014074976A1

文献信息

• [EN] COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISEASES OR INJURY<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT DE MALADIES OU DE LÉSIONS NEUROLOGIQUES
  申请人：MUSC FOUND FOR RES DEV

  公开号：WO2014074976A1

  公开（公告）日：2014-05-15

  Provided are compounds for the treatment of neurological diseases or injuries, including neurodegenerative diseases, stroke, trauma, epilepsy, acute and chronic kidney injuries, diabetes mellitus, and/or seizures. In some embodiments, derivatives of vitamin K are provided.

  提供了用于治疗神经系统疾病或损伤的化合物，包括神经退行性疾病、中风、创伤、癫痫、急性和慢性肾脏损伤、糖尿病和/或癫痫。在某些实施例中，提供了维生素K的衍生物。
• COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISEASES OR INJURY
  申请人：MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

  公开号：US20150320702A1

  公开（公告）日：2015-11-12

  Provided are compounds for the treatment of neurological diseases or injuries, including neurodegenerative diseases, stroke, trauma, epilepsy, acute and chronic kidney injuries, diabetes mellitus, and/or seizures. In some embodiments, derivatives of vitamin K are provided.

  提供了用于治疗神经系统疾病或损伤的化合物，包括神经退行性疾病、中风、创伤、癫痫、急性和慢性肾脏损伤、糖尿病和/或癫痫。在某些实施例中，提供了维生素K的衍生物。
• Compositions and methods for treating neurological diseases or injury
  申请人：MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

  公开号：US10391070B2

  公开（公告）日：2019-08-27

  Provided are compounds for the treatment of neurological diseases or injuries, including neurodegenerative diseases, stroke, trauma, epilepsy, acute and chronic kidney injuries, diabetes mellitus, and/or seizures. In some embodiments, derivatives of vitamin K are provided.

  所提供的化合物用于治疗神经系统疾病或损伤，包括神经退行性疾病、中风、创伤、癫痫、急性和慢性肾损伤、糖尿病和/或癫痫发作。 在某些实施方案中，提供了维生素 K 的衍生物。
• US9861596B2
  申请人：——

  公开号：US9861596B2

  公开（公告）日：2018-01-09
• Structure–Activity Relationship Study of Vitamin K Derivatives Yields Highly Potent Neuroprotective Agents
  作者：Benjamin J. Josey、Elizabeth S. Inks、Xuejun Wen、C. James Chou

  DOI：10.1021/jm301485d

  日期：2013.2.14

  Historically known for its role in blood coagulation and bone formation, vitamin K (VK) has begun to emerge as an important nutrient for brain function. While VK involvement in the brain has not been fully explored, it is well-known that oxidative stress plays a critical role in neuro-degenerative diseases. It was recently reported that VK protects neurons and oligodendrocytes from oxidative injury and rescues Drosophila from mitochondrial defects associated with Parkinson's disease. In this study, we take a chemical approach to define the optimal and minimum pharmacophore responsible for the neuroprotective effects of VK. In doing so, we have developed a series of potent VK analogues with favorable drug characteristics that provide full protection at nanomolar concentrations in a well-defined model of neuronal oxidative stress. Additionally, we have characterized key cellular responses and biomarkers consistent with the compounds' ability to rescue cells from oxidative stress induced cell death.