1-(3-methyl-2-thiophenyl)morpholine | 1421278-54-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-(3-methyl-2-thiophenyl)morpholine
• CAS: 1421278-54-7
• 化学式: C₉H₁₃NOS
• 分子量: 183.274
• InChiKey: FBTBYEYCUWBXDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.89
• 重原子数：
  12.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  12.47
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  3-甲基噻吩 在 tetrakis(acetonitrile)copper(I)tetrafluoroborate 、 N,N-二异丙基乙胺 作用下， 以 二甲基亚砜 、 乙腈 为溶剂， 反应 12.5h， 生成 1-(3-methyl-2-thiophenyl)morpholine
  参考文献：
  名称：

  Copper-Catalyzed para-Selective C–H Amination of Electron-Rich Arenes

  摘要：

  A one-pot two-step method for para-selective C-H amination of carbocyclic arenes comprises the in situ formation of unsymmetrical diaryl-lambda(3)-iodanes followed by their Cu(I)-catalyzed reaction with a range of N-unprotected amines.

  DOI：

  10.1021/acscatal.5b01992

文献信息

• Synthesis and structural characterization of palladium(II) thiosemicarbazone complex: application to the Buchwald–Hartwig amination reaction
  作者：Rupesh Narayana Prabhu、Rengan Ramesh

  DOI：10.1016/j.tetlet.2012.12.070

  日期：2013.2

  A simple route to synthesize mononuclear palladium(II) thiosemicarbazone complex has been described. Elemental analysis, spectral methods and single crystal X-ray diffraction analysis were used to confirm the composition of the complex. The new complex acts as an active homogeneous catalyst for the Buchwald-Hartwig amination reaction of a wide range of aryl and heteroaryl halides (bromides and chlorides), including activating, neutral and deactivating substrates, with various secondary amines under optimized conditions. (C) 2012 Elsevier Ltd. All rights reserved.