6-methoxy-3-methoxycarbonylmethyl-2,3-dihydrobenzofuran | 93772-88-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 香豆素
• 英文名称: 6-methoxy-3-methoxycarbonylmethyl-2,3-dihydrobenzofuran
• 英文别名: Methyl 6-Methoxy-2,3-dihydrobenzofuran-3-acetate；methyl 2-(6-methoxy-2,3-dihydro-1-benzofuran-3-yl)acetate
• CAS: 93772-88-4
• 化学式: C₁₂H₁₄O₄
• 分子量: 222.241
• InChiKey: XXWQHQBXALOGPA-UHFFFAOYSA-N

物化性质

• 沸点：
  303.1±35.0 °C(Predicted)
• 密度：
  1.162±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-methoxy-3-methoxycarbonylmethyl-2,3-dihydrobenzofuran 以 水 为溶剂， 生成 2,3-二氢-6-羟基-3-香豆酮乙酸甲酯
  参考文献：
  名称：

  Electron impact mass spectrometry of some 2,3-dihydro-1-benzofuran-3-acetic acids

  摘要：

  AbstractThe mass spectrometric behaviour of four 2,3‐dihydro‐1‐benzofuran‐3‐acetic acids has been studied in detail with the aid of exact mass measurements, linked scans, collisionally activated decomposition, mass analysed ion kinetic energy spectra and labelling experiments. Unusual fragmentation pathways are emphasized for which mechanisms are proposed.

  DOI：

  10.1002/oms.1210200112
• 作为产物：
  描述：

  methyl 2'-hydroxy-4'-methoxycinnamate 、 dimethylsulfoxonium methylide 生成 6-methoxy-3-methoxycarbonylmethyl-2,3-dihydrobenzofuran
  参考文献：
  名称：

  Electron impact mass spectrometry of some 2,3-dihydro-1-benzofuran-3-acetic acids

  摘要：

  AbstractThe mass spectrometric behaviour of four 2,3‐dihydro‐1‐benzofuran‐3‐acetic acids has been studied in detail with the aid of exact mass measurements, linked scans, collisionally activated decomposition, mass analysed ion kinetic energy spectra and labelling experiments. Unusual fragmentation pathways are emphasized for which mechanisms are proposed.

  DOI：

  10.1002/oms.1210200112

文献信息

• FUSED CYCLIC COMPOUNDS
  申请人：Yasuma Tsuneo

  公开号：US20100004312A1

  公开（公告）日：2010-01-07

  The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof. The compound or a salt thereof or a prodrug thereof has a GPR40 receptor function modulating action and is useful as an insulin secretagogue or an agent for the prophylaxis or treatment of diabetes and the like.

  本发明提供一种化合物，其表示为公式（I）：其中每个符号如描述中所定义，或其盐。该化合物或其盐或其前药具有GPR40受体功能调节作用，并可用作胰岛素分泌剂或用于预防或治疗糖尿病等药物。
• Fused cyclic compounds
  申请人：Yasuma Tsuneo

  公开号：US20100197761A1

  公开（公告）日：2010-08-05

  The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof. The compound or a salt thereof or a prodrug thereof has a GPR40 receptor function modulating action and is useful as an insulin secretagogue or an agent for the prophylaxis or treatment of diabetes and the like.

  本发明提供一种化合物，其化学式表示为（I）：其中每个符号如描述中所定义，或其盐。该化合物或其盐或其前药具有GPR40受体功能调节作用，并且可用作胰岛素分泌剂或预防或治疗糖尿病等疾病的药物。
• Fused cyclic compounds as GPR40 receptor modulators
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP2431367A2

  公开（公告）日：2012-03-21

  The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof, and pharmaceutical compositions comprising said compound, useful as insulin secretagogues or agents for the treatment of the diabetes (GPR40 receptor modulators).

  本发明提供了一种由式 (I) 表示的化合物： 其中各符号如描述中所定义，或其盐，以及包含所述化合物的药物组合物，可用作胰岛素促泌剂或治疗糖尿病的药物（GPR40 受体调节剂）。
• Bravo, Pierfrancesco; Gentile, Anna; Ticozzi, Calimero, Gazzetta Chimica Italiana, 1984, vol. 114, # 3/4, p. 89 - 92
  作者：Bravo, Pierfrancesco、Gentile, Anna、Ticozzi, Calimero

  DOI：——

  日期：——
• US7732626B2
  申请人：——

  公开号：US7732626B2

  公开（公告）日：2010-06-08