2-(2-methyl-2,3-dihydro-1H-perimidin-2-yl)benzene-1,3-diol | 1426168-04-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(2-methyl-2,3-dihydro-1H-perimidin-2-yl)benzene-1,3-diol
• 英文别名: 2-(2-Methyl-1,3-dihydroperimidin-2-yl)benzene-1,3-diol；2-(2-methyl-1,3-dihydroperimidin-2-yl)benzene-1,3-diol
• CAS: 1426168-04-8
• 化学式: C₁₈H₁₆N₂O₂
• 分子量: 292.337
• InChiKey: FPCHAXYBALFLGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  64.5
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,6-二羟基苯乙酮 、 1,8-二氨基萘 在 indium(III) chloride 、 对甲苯磺酸 作用下， 以 乙醇 为溶剂， 反应 72.0h， 以19%的产率得到2-(2-methyl-2,3-dihydro-1H-perimidin-2-yl)benzene-1,3-diol
  参考文献：
  名称：

  Preparation, structure, and metal coordination of 2-(2-methyl-2,3-dihydro-1H-perimidin-2-yl)benzene-1,3-diol

  摘要：

  A perimidine with four donor sites, 2-(2-methyl-2,3-dihydro-1H-perimidin-2-yl)benzene-1,3-diol has been prepared through InCl3 catalysis from commercial precursors. It exhibits in solid state a bent structure, with two ring systems substantially orthogonal. A ruthenium(II) complex catalyzes the transfer hydrogenation of phenylalkyl ketones by isopropanol with good efficiency. (c) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.12.088
• 作为试剂：
  描述：

  2,2,2-三甲基苯乙酮 在 [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 2-(2-methyl-2,3-dihydro-1H-perimidin-2-yl)benzene-1,3-diol 、 sodium carbonate 、 异丙醇 、 potassium hydroxide 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以96%的产率得到2,2-二甲基-1-苯基-1-丙醇
  参考文献：
  名称：

  Preparation, structure, and metal coordination of 2-(2-methyl-2,3-dihydro-1H-perimidin-2-yl)benzene-1,3-diol

  摘要：

  A perimidine with four donor sites, 2-(2-methyl-2,3-dihydro-1H-perimidin-2-yl)benzene-1,3-diol has been prepared through InCl3 catalysis from commercial precursors. It exhibits in solid state a bent structure, with two ring systems substantially orthogonal. A ruthenium(II) complex catalyzes the transfer hydrogenation of phenylalkyl ketones by isopropanol with good efficiency. (c) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.12.088

文献信息

• Preparation, structure, and metal coordination of 2-(2-methyl-2,3-dihydro-1H-perimidin-2-yl)benzene-1,3-diol
  作者：Maria Elena Cucciolito、Barbara Panunzi、Francesco Ruffo、Angela Tuzi

  DOI：10.1016/j.tetlet.2012.12.088

  日期：2013.3

  A perimidine with four donor sites, 2-(2-methyl-2,3-dihydro-1H-perimidin-2-yl)benzene-1,3-diol has been prepared through InCl3 catalysis from commercial precursors. It exhibits in solid state a bent structure, with two ring systems substantially orthogonal. A ruthenium(II) complex catalyzes the transfer hydrogenation of phenylalkyl ketones by isopropanol with good efficiency. (c) 2013 Elsevier Ltd. All rights reserved.