1,3,2-dioxaphosphorinane-2-methanol-α,5,5-trimethyl-α-phenyl-2-oxide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: 1,3,2-dioxaphosphorinane-2-methanol-α,5,5-trimethyl-α-phenyl-2-oxide
• 英文别名: 2-(1-hydroxy-1-phenylethyl)-5,5-dimethyl-1,3,2-dioxaphosphinane 2-oxide；1-(5,5-Dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinan-2-yl)-1-phenylethanol；1-(5,5-dimethyl-2-oxo-1,3,2λ5-dioxaphosphinan-2-yl)-1-phenylethanol
• 化学式: C₁₃H₁₉O₄P
• 分子量: 270.265
• InChiKey: YVAUPMVSVRWYIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,3,2-dioxaphosphorinane-2-methanol-α,5,5-trimethyl-α-phenyl-2-oxide 在 三乙胺 、 三氯氧磷 、 甲酸 作用下， 生成
  参考文献：
  名称：

  CN115611946

  摘要：

  公开号：
• 作为产物：
  描述：

  2,2-二甲基-1,3-丙二醇 在 甲酸 、 三乙胺 、 三氯氧磷 作用下， 以 环己烷 为溶剂， 反应 3.0h， 生成 1,3,2-dioxaphosphorinane-2-methanol-α,5,5-trimethyl-α-phenyl-2-oxide
  参考文献：
  名称：

  CN115611946

  摘要：

  公开号：

文献信息

• Convenient approach to synthesize tertiary α-hydroxy cyclic phosphonates catalyzed by potassium carbonate under solvent-free conditions
  作者：Chubei Wang、Jianwei Zhou、Jianfeng Liu、Liangliang Chu、Hongwu He

  DOI：10.1080/10426507.2013.860532

  日期：2014.9.2

  GRAPHICAL ABSTRACT Abstract A new environmentally benign, convenient, and easy method for the synthesis of tertiary α-hydroxy cyclic phosphonates was developed. In the presence of potassium carbonate, aromatic/heteroaromatic ketones and base-sensitive ketones can react with phosphite to form tertiary α-hydroxyphosphonates under solvent-free and mild conditions.

  图形摘要 摘要 开发了一种环境友好、方便且简单的合成叔α-羟基环状膦酸酯的新方法。在碳酸钾的存在下，芳族/杂芳族酮和碱敏感性酮可以在无溶剂和温和的条件下与亚磷酸酯反应形成叔α-羟基膦酸酯。
• Solubilities of 1,3,2-Dioxaphosphorinane-2-methanol-α,5,5-trimethyl-α-phenyl-2-oxide in Selected Solvents between 278.15 K and 343.15 K
  作者：Yong Yuan、Rui-lan Fan、Lai Guo、Cong-yan Chen、Qian-qiong Zhao

  DOI：10.1021/je500806u

  日期：2015.3.12

  The mole fraction solubilities of 1,3)2-dioxaphosphoririane-2-methanol-alpha,5,5-trirnethyl-alpha-phenyl-2-oxide in different-Organic solvents inducting acetonitrile, acetone; ethyl acetate, 1,2,dichloroethane, Methanol, ethanol, and chloroform were measured at a designated temperature range of (278.15 to 343.15) K and at atmospheric pressure by the gravimetrical method. The compound's structure and thermal stability were characterized by infrared, spectroscopy, nuclear magnetic resonante (H-1 NMR and(31)P NMR), mass Spectroscopy, elemental analysis, and thermogravimetric analysis. The mole fraction solubilities of 1,3,2-dioxaphosphorinane-2-methanol-alpha,5,5-trimethyl-alpha-phenyl-2-oxide in the above-mentioned organic solvents were correlated as the Apelblat equation, and the calculated values with equations showed good consistency with the experimental values. The root-mean-square deviation was less than 0.010 % and the average relative error Was less than 0.11 % in all the experiments.
• CN115611946
  申请人：——

  公开号：——

  公开（公告）日：——