tetra-ethyl-ammonium ethylsulfate | 4497-24-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: tetra-ethyl-ammonium ethylsulfate
• 英文别名: tetraethyl-ammonium; ethyl sulfate；Tetraaethyl-ammonium; Aethylsulfat；tetraethylammonium ethyl-sulfate；tetraethylammonium ethylsulfate；tetraethylammonium ethosulfate；Tetraethylammonium ethyl sulfate；ethyl sulfate;tetraethylazanium
• CAS: 4497-24-9
• 化学式: C₂H₅O₄S*C₈H₂₀N
• 分子量: 255.379
• InChiKey: HCWMUANODLPMEO-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.37
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  74.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  硫酸二乙酯 、 三乙胺 以 甲苯 为溶剂， 反应 4.0h， 生成 tetra-ethyl-ammonium ethylsulfate
  参考文献：
  名称：

  Probing the Mechanism of Baylis-Hillman Reaction in Ionic Liquids

  摘要：

  The kinetic data for a Baylis-Hillman reaction in certain ionic liquids possessing ethylsulfate anion [EtSO4](-) demonstrate that the rate determining step (RIDS) is second order in aldehyde, but first order in acrylate and DABCO. This observation is similar to the one made by McQuade et al., who carried out this reaction in an aprotic polar solvent like DMSO. However, this is in contrast to the general observation that ADS is first order in aldehyde, acrylate, and DABCO in organic solvents.

  DOI：

  10.1021/jo301348k
• 作为试剂：
  描述：

  3-氨基吲唑 、 alkaline earth salt of/the/ methylsulfuric acid 在 diphosphorus pentasulfide 、 tetra-ethyl-ammonium ethylsulfate 作用下， 以 1,4-二氧六环 、 硫酸 为溶剂， 反应 18.0h， 生成 N-[3-(2,6-二甲基-1-哌啶基)丙基]-1H-吲唑-3-胺
  参考文献：
  名称：

  Studies on 3-aminoindazoles. I. Synthesis of 1- or 3-(substituted 3-amino)indazoles.

  摘要：

  通过以下三种方法合成了各种具有消炎作用的 1-或 3-（取代的 3-氨基）吲唑。1) 3-氨基吲唑（1）与丙烯酰胺（2a 和 2b）反应，得到酰胺衍生物（3a 和 3b），3a 和 3b 的 3 位上有氨基甲酰乙氨基。酰胺衍生物（3a 和 3b）经 P2S5 处理后转化为硫代酰胺衍生物（4a 和 4b）。电极还原 4a 和 4b，得到 3-（取代的 3-氨基）吲唑（5a 和 5b）。2) 1 与氨基烷基卤化物（6c-r）反应，得到 3-（取代的 3-氨基）吲唑（5c-r）和 1-（取代的 3-氨基）吲唑（7c-r），比例为 3 : 1。化合物 9 与氨基烷基卤化物 (6o-r) 反应，得到 9 的 1-取代衍生物 (10s-z)，10a-z 与水合肼反应，得到 1-（取代的 3-氨基）吲唑衍生物 (5s-z)。

  DOI：

  10.1248/cpb.35.2292

文献信息

• Process for preparing 4-aminodiphenylamine
  申请人：Wang Nongyue

  公开号：US20050065376A1

  公开（公告）日：2005-03-24

  The present invention discloses a process for preparing 4-aminodiphenylamine, which process uses nitrobenzene and aniline as raw materials, a complex base catalyst as condensation catalyst and a powdery composite catalyst as hydrogenation catalyst, and comprises five process stages: condensation; separation I; hydrogenation; separation II; and refining. The process can be continuously carried out. By selecting a complex base catalyst to catalyze the condensation reaction and separating it prior to the hydrogenation, the problem that the complex base catalysts thermally decompose in the hydrogenation reaction is avoided, the selectable range of hydrogenation catalysts is largely enlarged so that it is possible to select cheaper hydrogenation catalyst, and the selection of production process and equipment is easier and further industrialization is easier. The complex base catalysts used in the present invention are inexpensive and have higher catalytic activity. The process can be carried out at mild conditions and can adapt to broad range of water content, by-product is less and conversion and selectivity are higher. The operational strength is low, no corrosive liquid is produced, and environment pollution is reduced. The purity of 4-aminodiphenylamine prepared can exceed 99 wt.-%, and the yield in the industrial production process can be over 95%.

  本发明公开了一种制备4-氨基二苯胺的方法，该方法使用硝基苯和苯胺作为原料，复合碱基催化剂作为缩合催化剂，粉状复合催化剂作为加氢催化剂，并包括五个工艺阶段：缩合；分离I；加氢；分离II；和精制。该方法可以连续进行。通过选择复合碱基催化剂催化缩合反应并在加氢之前分离它，避免了复合碱基催化剂在加氢反应中热分解的问题，大大扩大了可选择的加氢催化剂范围，从而可以选择更便宜的加氢催化剂，并且生产工艺和设备的选择更容易，进一步工业化更容易。本发明中使用的复合碱基催化剂价格低廉且具有较高的催化活性。该方法可以在温和条件下进行，并且可以适应广泛的含水量范围，副产物较少，转化率和选择性较高。操作强度低，不产生腐蚀性液体，减少了环境污染。制备的4-氨基二苯胺的纯度可以超过99重量％，工业生产过程中的产率可以超过95％。
• Method for Producing Quaternary Ammonium Compounds
  申请人：Szarvas Laszlo

  公开号：US20070254822A1

  公开（公告）日：2007-11-01

  The present invention relates to a process for preparing quaternary ammonium compounds, which comprises reacting compounds comprising an sp 3 -hybridized nitrogen atom with a dialkyl sulfate or trialkyl phosphate and subjecting the resulting ammonium compound to an anion exchange.

  本发明涉及一种制备季铵盐化合物的方法，包括将含有sp3杂化氮原子的化合物与二烷基硫酸盐或三烷基磷酸酯反应，并将所得的铵盐化合物进行阴离子交换。
• PROCESS FOR PREPARING 4-AMINODIPHENYLAMINE
  申请人：Feng Xiaogen

  公开号：US20080039657A1

  公开（公告）日：2008-02-14

  A process for preparing 4-aminodiphenylamine having the steps of reacting nitrobenzene and aniline in the presence of a complex base catalyst, hydrogenating the reaction mixture with hydrogen, a powdery composite catalyst, and a hydrogenation solvent; separating, recovering, and reusing the complex base catalyst and the powdery composite catalyst from the reaction mixture; separating, recovering, and reusing aniline, and optionally water, from the reaction mixture; refining the reaction mixture to obtain 4-aminodiphenylamine. The complex base catalyst comprises tetraalkyl ammonium hydroxide, and tetraalkyl ammonium salt.

  一种制备4-氨基二苯胺的方法，包括以下步骤：在复合碱催化剂存在下，使硝基苯和苯胺反应；用氢气、粉状复合催化剂和氢化溶剂对反应混合物进行氢化；从反应混合物中分离、回收并重复使用复合碱催化剂和粉状复合催化剂；从反应混合物中分离、回收并重复使用苯胺和可选的水；对反应混合物进行精制以获得4-氨基二苯胺。复合碱催化剂包括四烷基铵氢氧化物和四烷基铵盐。
• PROCESS FOR PREPARING ALKYLATED P-PHENYLENEDIAMINES
  申请人：FENG Xiaogen

  公开号：US20130066113A1

  公开（公告）日：2013-03-14

  A process for preparing alkylated p-phenylenediamine having the steps of reacting aniline and nitrobenzene in presence of a complex base catalyst to obtain 4-aminodiphenylamine intermediates, hydrogenating the 4-aminodiphenylamine intermediates to 4-aminodiphenylamine in presence of a hydrogenation catalyst, and reductively alkylating the 4-aminodiphenylamine to alkylated p-phenylenediamine.

  一种制备烷基化对苯二胺的方法，包括以下步骤：在复合碱催化剂的存在下，使苯胺和硝基苯反应，得到4-氨基二苯胺中间体；在加氢催化剂的存在下，将4-氨基二苯胺中间体加氢得到4-氨基二苯胺；然后在还原剂的存在下，对4-氨基二苯胺进行烷基化反应，得到烷基化对苯二胺。
• A PROCESS FOR PREPARING 4-AMINODIPHENYLAMINE
  申请人：Wang, Nongyue

  公开号：EP1591438A1

  公开（公告）日：2005-11-02

  The present invention discloses a process for preparing 4-aminodiphenylamine, which process uses nitrobenzene and aniline as raw materials, a complex base catalyst as condensation catalyst and a powdery composite catalyst as hydrogenation catalyst, and comprises five process stages: condensation; hydrogenation; separating, recovering and reusing the complex base catalyst and separating, recovering and reusing the powdery composite catalyst which is optionally at least partially regenerated; separating, recovering and reusing aniline and optionally separating, recovering and reusing hydrogenation solvent; and refining.The complex base catalyst and powdery composite catalyst used in the present invention have lower production cost and higher catalytic activity; the whole process can be continuously carried out and is suitable for industrial scale production; reaction conditions are mild, and by-product is less. The purity of 4-aminodiphenylamine prepared can exceed 99 wt.-%, and the yield in the industrial production process can be over 95%.

  本发明公开了一种制备4-氨基二苯胺的工艺，该工艺以硝基苯和苯胺为原料，以络合碱催化剂为缩合催化剂，以粉状复合催化剂为加氢催化剂，包括五个工艺阶段：缩合；加氢；络合碱催化剂的分离、回收和再利用，以及粉状复合催化剂的分离、回收和再利用（可选择至少部分再生）；苯胺的分离、回收和再利用，以及加氢溶剂的分离、回收和再利用；精制。本发明中使用的复合碱催化剂和粉状复合催化剂生产成本低，催化活性高；整个过程可连续进行，适合工业化生产；反应条件温和，副产物少。制备的 4-氨基二苯胺纯度可达 99 wt.-%以上，工业生产过程中的收率可达 95%以上。