1,2-bis(11H-indeno[2,1-b]quinoxalin-11-ylidene)hydrazine | 1544692-24-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1,2-bis(11H-indeno[2,1-b]quinoxalin-11-ylidene)hydrazine
• 英文别名: 1,2-di(11H-indeno[2,1-b]quinoxalin-11-ylidene)hydrazine
• CAS: 1544692-24-1
• 化学式: C₃₀H₁₆N₆
• 分子量: 460.497
• InChiKey: CWZYIYACFCLFSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.82
• 重原子数：
  36.0
• 可旋转键数：
  1.0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  76.28
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  11H-茚并[1,2-b]喹喔啉-11-酮 在 2-碘苯甲酰肼 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 以25%的产率得到1,2-bis(11H-indeno[2,1-b]quinoxalin-11-ylidene)hydrazine
  参考文献：
  名称：

  Synthesis of novel indenoquinoxaline derivatives as potent α-glucosidase inhibitors

  摘要：

  A series of new N-(11H-Indeno[1,2-b]quinoxalin-11-ylidene)benzohydrazide derivatives (3a-3p) were synthesized and evaluated for their alpha-glucosidase inhibitory activity. The synthesized compounds 3d, 3f, 3g, 3k, 3n, 3p and 4 showed significant alpha-glucosidase inhibitory activity as compared to acrabose, a standard drug used to treat type II diabetes. Structures of the synthesized compounds were determined by using FT-IR, H-1 NMR, C-13 NMR, mass spectrometry and elemental analysis techniques. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.12.024

文献信息

• Synthesis of novel indenoquinoxaline derivatives as potent α-glucosidase inhibitors
  作者：Madiha Sahar Khan、Munawar Ali Munawar、Mohammad Ashraf、Umber Alam、Athar Ata、Abdullah Mohamed Asiri、Samina Kousar、Misbahul Ain Khan

  DOI：10.1016/j.bmc.2013.12.024

  日期：2014.2

  A series of new N-(11H-Indeno[1,2-b]quinoxalin-11-ylidene)benzohydrazide derivatives (3a-3p) were synthesized and evaluated for their alpha-glucosidase inhibitory activity. The synthesized compounds 3d, 3f, 3g, 3k, 3n, 3p and 4 showed significant alpha-glucosidase inhibitory activity as compared to acrabose, a standard drug used to treat type II diabetes. Structures of the synthesized compounds were determined by using FT-IR, H-1 NMR, C-13 NMR, mass spectrometry and elemental analysis techniques. (C) 2013 Elsevier Ltd. All rights reserved.