N-(Benzotriazol-1-yl-naphthalen-1-yl-methyl)-benzamide | 134004-82-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(Benzotriazol-1-yl-naphthalen-1-yl-methyl)-benzamide
• 英文别名: N-[benzotriazol-1-yl(naphthalen-1-yl)methyl]benzamide
• CAS: 134004-82-3
• 化学式: C₂₄H₁₈N₄O
• 分子量: 378.433
• InChiKey: PZVDOSWOTAONHF-UHFFFAOYSA-N

物化性质

• 熔点：
  212-214 °C
• 沸点：
  695.3±55.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  59.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(Benzotriazol-1-yl-naphthalen-1-yl-methyl)-benzamide 、 甲基丙二酸二乙酯 在 三氯化铝 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 以60%的产率得到2-(Benzoylamino-naphthalen-1-yl-methyl)-2-methyl-malonic acid diethyl ester
  参考文献：
  名称：

  N-(1-benzotriazol-1-ylalkyl)amides, versatile .alpha.-amidoalkylation reagents. 1. .alpha.-Amidoalkylation of CH acids

  摘要：

  N-(1-Benzotriazol-1-ylalkyl)amides 2, easily prepared from an amide and an aldehyde with benzotriazole, react smoothly with CH acids under mild conditions to give the alpha-amidoalkylation products in good yields. Benzotriazole aminals also react with CH acids in the presence of methyl iodide.

  DOI：

  10.1021/jo00014a020
• 作为产物：
  描述：

  T406石油添加剂 、 苯甲酰胺 、 1-萘甲醛 以 甲苯 为溶剂， 反应 24.0h， 以49%的产率得到N-(Benzotriazol-1-yl-naphthalen-1-yl-methyl)-benzamide
  参考文献：
  名称：

  N-(1-benzotriazol-1-ylalkyl)amides, versatile .alpha.-amidoalkylation reagents. 1. .alpha.-Amidoalkylation of CH acids

  摘要：

  N-(1-Benzotriazol-1-ylalkyl)amides 2, easily prepared from an amide and an aldehyde with benzotriazole, react smoothly with CH acids under mild conditions to give the alpha-amidoalkylation products in good yields. Benzotriazole aminals also react with CH acids in the presence of methyl iodide.

  DOI：

  10.1021/jo00014a020

文献信息

• <i>N</i>-[1-(Benzotriazol-1-yl)alkyl]amides, Versatile Amidoalkylation Reagents. Part 3.¹Syntheses of Open-Chain<i>N</i>-Protected-Hemithioaminals
  作者：Alan R. Katritzky、Ichiro Takahashi、Wei-Qiang Fan、Juliusz Pernak

  DOI：10.1055/s-1991-28407

  日期：——

  N-[(1-Benzotriazol-1-yl)alkyl]amides 1 react readily with a variety of thiols (both aliphatic and aromatic) and sodium sulfide under mild conditions to give N-acylhemithioaminals in good yields.

  N-[(1-苯并三唑-1-基)烷基]酰胺1在温和条件下能与多种硫醇（包括脂肪族和芳香族硫醇）以及硫化钠迅速反应，以良好的产率生成N-酰基半硫亚胺。
• <i>N</i>-[1-(Benzotriazol-1-yl)alkyl]amides, Versatile Amidoalkylation Reagents. Part 2. Amidoalkylation of Aromatic Compounds
  作者：Alan R. Katritzky、Juliusz Pernak、Wei-Qiang Fan

  DOI：10.1055/s-1991-26596

  日期：——

  N-[(1-Benzotriazol-1-yl)alkyl]amides 4 react readily with a variety of active aromatic and heterocyclic compounds under mild conditions to give the amidoalkylation products in good yields.

  N-[(1-苯并三唑-1-基)烷基]酰胺4在温和条件下能与多种活性芳香族和杂环化合物迅速反应，生成酰胺烷基化产物，并且产率良好。
• N-[1-(Benzotriazol-1-yl)alkyl]amides, versatile amidoalkylation reagents. Part 4. A New Synthetic Route to 4H-1,3-Oxazines
  作者：Alan R. Katritzky、J. Pernak、Wei-Qiang Fan

  DOI：10.1002/prac.19923340203

  日期：——

  A variety of 2,4,6-tri- and 2,4,5,6-tetrasubstituted 4H-1,3-oxazines (7 a-i) were synthesized in excellent yields by the reaction of acetylenes (5) in the presence of aluminum chloride with N-[1-(benzotriazol-1-yl) alkyl]amides 4, themselves readily prepared from benzotriazole (1) with amides (2) and aldehydes (3).
• KATRITZKY, ALAN R.;PERNAK, JULIUSZ;FAN, WEI-QIANG;SACZEWSKI, FRANCISZEK, J. ORG. CHEM., 56,(1991) N4, C. 4439-4443
  作者：KATRITZKY, ALAN R.、PERNAK, JULIUSZ、FAN, WEI-QIANG、SACZEWSKI, FRANCISZEK

  DOI：——

  日期：——
• N-(1-benzotriazol-1-ylalkyl)amides, versatile .alpha.-amidoalkylation reagents. 1. .alpha.-Amidoalkylation of CH acids
  作者：Alan R. Katritzky、Juliusz Pernak、Wei Qiang Fan、Franciszek Saczewski

  DOI：10.1021/jo00014a020

  日期：1991.7

  N-(1-Benzotriazol-1-ylalkyl)amides 2, easily prepared from an amide and an aldehyde with benzotriazole, react smoothly with CH acids under mild conditions to give the alpha-amidoalkylation products in good yields. Benzotriazole aminals also react with CH acids in the presence of methyl iodide.