4-(5,6,7,8-tetrahydro-3-hydroxy-2-naphthyl)butanal

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 4-(5,6,7,8-tetrahydro-3-hydroxy-2-naphthyl)butanal
• 英文别名: 4-(3-Hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)butanal；4-(3-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)butanal
• 化学式: C₁₄H₁₈O₂
• 分子量: 218.296
• InChiKey: QNYBALJRNICEIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对称八氢蒽 在 N-羟基邻苯二甲酰亚胺 、 偶氮二异丁腈 、 硫酸 、 氧气 作用下， 以 乙腈 为溶剂， 25.0~75.0 ℃ 、101.33 kPa 条件下， 反应 5.0h， 生成 4-(5,6,7,8-tetrahydro-3-hydroxy-2-naphthyl)butanal
  参考文献：
  名称：

  Synthesis of aromatic aldehydes by aerobic oxidation of hydroaromatic compounds and diarylalkanes using N-hydroxyphthalimide (NHPI) as a key catalyst

  摘要：

  Aerobic oxidation of hydroaromatic compounds and diarylalkanes by N-hydroxyphthalimide (NHPI) under mild conditions afforded the corresponding hydroperoxides in high selectivity. Treatment of the resulting hydroperoxides with sulfuric acid followed by neutralization by a base resulted in phenol and aromatic aldehydes in high selectivity. This method provides a convenient synthetic route to aldehydes involving an aromatic moiety. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.12.048

文献信息

• Synthesis of aromatic aldehydes by aerobic oxidation of hydroaromatic compounds and diarylalkanes using N-hydroxyphthalimide (NHPI) as a key catalyst
  作者：Yasuhiro Aoki、Satoshi Sakaguchi、Yasutaka Ishii

  DOI：10.1016/j.tet.2005.12.048

  日期：2006.3

  Aerobic oxidation of hydroaromatic compounds and diarylalkanes by N-hydroxyphthalimide (NHPI) under mild conditions afforded the corresponding hydroperoxides in high selectivity. Treatment of the resulting hydroperoxides with sulfuric acid followed by neutralization by a base resulted in phenol and aromatic aldehydes in high selectivity. This method provides a convenient synthetic route to aldehydes involving an aromatic moiety. (c) 2005 Elsevier Ltd. All rights reserved.