N-(2-tetrahydropyran-2-yloxy-ethyl)-phthalimide | 55694-50-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N-(2-tetrahydropyran-2-yloxy-ethyl)-phthalimide
• 英文别名: 1H-Isoindole-1,3(2H)-dione, 2-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]-；2-[2-(oxan-2-yloxy)ethyl]isoindole-1,3-dione
• CAS: 55694-50-3
• 化学式: C₁₅H₁₇NO₄
• 分子量: 275.304
• InChiKey: HIMTUMSPOWFFCO-UHFFFAOYSA-N

物化性质

• 沸点：
  427.1±40.0 °C(Predicted)
• 密度：
  1.29±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(2-tetrahydropyran-2-yloxy-ethyl)-phthalimide 在 indium(III) triflate 作用下， 以 甲醇 、 水 为溶剂， 反应 7.0h， 以81%的产率得到N-羟乙基酞酰亚胺
  参考文献：
  名称：

  A fast and practical approach to tetrahydropyranylation and depyranylation of alcohols using indium triflate

  摘要：

  Indium triflate-mediated tetrahydropyranylation of alcohols in dichloromethane and depyranylation of these products in aqueous methanol utilizing the same reagent but different molar ratio is described. In addition, indium triflate-promoted conversion of tetrahydropyran ethers to their corresponding acetates has also been described. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01864-6
• 作为产物：
  描述：

  3,4-二氢-2H-吡喃 、 N-羟乙基酞酰亚胺 在 indium(III) triflate 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以64%的产率得到N-(2-tetrahydropyran-2-yloxy-ethyl)-phthalimide
  参考文献：
  名称：

  A fast and practical approach to tetrahydropyranylation and depyranylation of alcohols using indium triflate

  摘要：

  Indium triflate-mediated tetrahydropyranylation of alcohols in dichloromethane and depyranylation of these products in aqueous methanol utilizing the same reagent but different molar ratio is described. In addition, indium triflate-promoted conversion of tetrahydropyran ethers to their corresponding acetates has also been described. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01864-6

文献信息

• One-Step Transformation of Tetrahydropyranyl Ethers Using Indium(III) Triflate as the Catalyst
  作者：Tomoko Mineno、Nana Nikaido、Hisao Kansui

  DOI：10.1248/cpb.57.1167

  日期：——

  one-step transformation of tetrahydropyranyl (THP) ethers is described. According to our earlier experiments, indium(III) triflate has proven to be an efficient catalyst for the transformation of THP ethers into their corresponding acetates. In further intensive work, we have developed a useful transforming reaction of THP ethers using various anhydride moieties. Indium(III) triflate was confirmed as a suitable

  描述了四氢吡喃基（THP）醚的会聚一步式转化。根据我们之前的实验，已证明三氟甲磺酸铟（III）是将THP醚转化为相应的乙酸盐的有效催化剂。在进一步的深入研究中，我们开发了使用各种酸酐部分的THP醚的有用转化反应。三氟甲磺酸铟（III）被确认为合适的催化剂，收率良好至极佳。描述了这一单步转换的细节。
• A fast and practical approach to tetrahydropyranylation and depyranylation of alcohols using indium triflate
  作者：Tomoko Mineno

  DOI：10.1016/s0040-4039(02)01864-6

  日期：2002.10

  Indium triflate-mediated tetrahydropyranylation of alcohols in dichloromethane and depyranylation of these products in aqueous methanol utilizing the same reagent but different molar ratio is described. In addition, indium triflate-promoted conversion of tetrahydropyran ethers to their corresponding acetates has also been described. (C) 2002 Elsevier Science Ltd. All rights reserved.