Trans-4-carbethoxy-1-phenyl-1,2,3,4-tetrahydronaphthalin-1-carbonsaeure | 110876-79-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Trans-4-carbethoxy-1-phenyl-1,2,3,4-tetrahydronaphthalin-1-carbonsaeure
• 英文别名: (+/-)-1-phenyl-1,2,3,4-tetrahydro-naphthalene-dicarboxylic acid-(1r.4t)-4-ethyl ester；(+/-)-1-Phenyl-1,2,3,4-tetrahydro-naphthalin-dicarbonsaeure-(1r.4t)-4-aethylester；(1S,4R)-4-ethoxycarbonyl-1-phenyl-3,4-dihydro-2H-naphthalene-1-carboxylic acid
• CAS: 110876-79-4；141312-34-7
• 化学式: C₂₀H₂₀O₄
• 分子量: 324.376
• InChiKey: NZQZQDLQIIAZMC-UZLBHIALSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  L-苯基乳酸甲酯 在 硫酸 作用下， 以 甲醇 、 二氧化碳 、 水 、 异丙醇 为溶剂， 20.0~100.0 ℃ 、10.0 MPa 条件下， 反应 20.0h， 生成 Trans-4-carbethoxy-1-phenyl-1,2,3,4-tetrahydronaphthalin-1-carbonsaeure
  参考文献：
  名称：

  WO2008/49806

  摘要：

  公开号：

文献信息

• Smith; Forsberg, 1943, vol. 13, p. 161,165
  作者：Smith、Forsberg

  DOI：——

  日期：——
• PIPERIDINE OR PIPERAZINE SUBSTITUTED TETRAHYDRO-NAPHTHALENE-1-CARBOXYLIC ACID MTP INHIBITING COMPOUNDS
  申请人：Meerpoel Lieven

  公开号：US20090325980A1

  公开（公告）日：2009-12-31

  The present invention is concerned with novel piperidine or piperazine substituted tetrahydro-naphthalene-1-carboxylic acid derivatives having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes.
• MTP INHIBITING TETRAHYDRO-NAPHTHALENE-1-CARBOXYLIC ACID DERIVATIVES
  申请人：Meerpoel Lieven

  公开号：US20100016291A1

  公开（公告）日：2010-01-21

  The present invention is concerned with novel tetrahydro-naphthalene-1-carboxylic acid derivatives having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes. Formula (I).
• US8114880B2
  申请人：——

  公开号：US8114880B2

  公开（公告）日：2012-02-14
• US8158783B2
  申请人：——

  公开号：US8158783B2

  公开（公告）日：2012-04-17