5'-O-dimethoxytrityl-N2,N6-bis(phenoxyacetyl)-2,6-diaminopurine 2'-deoxyriboside | 156549-48-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 5'-O-dimethoxytrityl-N2,N6-bis(phenoxyacetyl)-2,6-diaminopurine 2'-deoxyriboside
• 英文别名: 5'-O-dimethoxytrityl-N²,N⁶-bis(phenoxyacetyl)-2,6-diaminopurine 2'-deoxyriboside；DMT-N²,N⁶-bisphenoxyacetyl-2'-deoxy-2-aminoadenosine
• CAS: 156549-48-3
• 化学式: C₄₇H₄₄N₆O₉
• 分子量: 836.901
• InChiKey: NDLLTNVPFCCJBE-GHWCIQRUSA-N

物化性质

• 密度：
  1.33±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.54
• 重原子数：
  62.0
• 可旋转键数：
  17.0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  177.41
• 氢给体数：
  3.0
• 氢受体数：
  13.0

反应信息

• 作为反应物：
  描述：

  2-氰乙基N,N-二异丙基氯亚磷酰胺 、 5'-O-dimethoxytrityl-N2,N6-bis(phenoxyacetyl)-2,6-diaminopurine 2'-deoxyriboside 生成 5'-O-dimethoxytrityl-N²,N⁶-bis(phenoxyacetyl)-2,6-diaminopurine-2'-deoxyriboside 3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite
  参考文献：
  名称：

  Stabilization of DNA:DNA and DNA:RNA duplexes by substitution of 2′-deoxyadenosine with 2′-deoxy-2-aminoadenosine

  摘要：

  Oligonucleotides containing either 2'-deoxyadenosine d(A) or 2'-deoxy-2-aminoadenosine d(A*) were synthesized and their relative binding affinities to complementary DNA and RNA targets compared. Substitution of dA with dA* resulted in sequence- and target-dependent changes in duplex stability.

  DOI：

  10.1016/s0040-4039(00)77151-6
• 作为产物：
  描述：

  N2-异丁酰-5'-O-(4,4'-二甲氧基三苯基)-2'-脱氧鸟苷 在 ammonium hydroxide 、 三甲基氯硅烷 、 氨 、 三氟乙酸酐 作用下， 以 1,4-二氧六环 为溶剂， 反应 72.75h， 生成 5'-O-dimethoxytrityl-N2,N6-bis(phenoxyacetyl)-2,6-diaminopurine 2'-deoxyriboside
  参考文献：
  名称：

  Stabilization of DNA:DNA and DNA:RNA duplexes by substitution of 2′-deoxyadenosine with 2′-deoxy-2-aminoadenosine

  摘要：

  Oligonucleotides containing either 2'-deoxyadenosine d(A) or 2'-deoxy-2-aminoadenosine d(A*) were synthesized and their relative binding affinities to complementary DNA and RNA targets compared. Substitution of dA with dA* resulted in sequence- and target-dependent changes in duplex stability.

  DOI：

  10.1016/s0040-4039(00)77151-6

文献信息

• Synthesis of Oligodeoxyribonucleotides Containing 2,6-Diaminopurine
  作者：Angeles Canol、Myron F. Goodman、Ramon Eritja

  DOI：10.1080/15257779408013258

  日期：1994.3

  The preparation of a new protected derivative of 2,6-diaminopurine 2'-deoxyriboside carrying two phenoxyacetyl groups is described. The new derivative is useful to prepare oligonucleotides containing 2,6-diaminopurine and it is deprotected at the same time as the standard protecting groups of the natural bases.