((1,3-dioxan-2-yl)methyl)tributylphosphonium bromide | 144774-39-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: ((1,3-dioxan-2-yl)methyl)tributylphosphonium bromide
• 英文别名: tributyl(1,3-dioxalan-2-ylmethyl)phosphonium bromide；tributyl-(1,3-dioxan-2-ylmethyl)phosphonium bromide；(1,3-dioxan-2-ylmethyl)tributylphosphonium bromide；1,3-dioxan-2-ylmethyltributylphosphoniumbromide；tributyl(1,3-dioxan-2-ylmethyl)phosphanium;bromide
• CAS: 144774-39-0
• 化学式: Br*C₁₇H₃₆O₂P
• 分子量: 383.349
• InChiKey: JBKMIQBGAFQGNO-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.17
• 重原子数：
  21
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  二茂铁甲醛 、 ((1,3-dioxan-2-yl)methyl)tributylphosphonium bromide 在 硫酸 、 sodium ethanolate 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 以54%的产率得到3-ferrocenyl-2-propenal
  参考文献：
  名称：

  Ribou, Anne-Cecile; Launay, Jean-Pierre; Sachtleben, Michelle L., Inorganic Chemistry, 1996, vol. 35, # 13, p. 3735 - 3740

  摘要：

  DOI：

文献信息

• .beta.-Alkoxyacrylates against malaria
  申请人：Hoffmann-La Roche Inc.

  公开号：US06084120A1

  公开（公告）日：2000-07-04

  The present invention relates to compounds having the formulae ##STR1## wherein R, R.sup.1, R.sup.6, R.sup.7, Rn.sup.8, X, and Z are defined herein, which are useful in the treatment or prophylaxis of malaria. The compounds of the present invention are especially useful in the treatment or prophylaxis of chloroquine-sensitive and chloroquine-resistant malaria.

  本发明涉及具有以下结构的化合物 ##STR1## 其中R、R.sup.1、R.sup.6、R.sup.7、Rn.sup.8、X和Z在此定义，这些化合物在治疗或预防疟疾方面具有用途。本发明的化合物在治疗或预防对氯喹敏感和氯喹耐药性疟疾方面特别有用。
• A structural study of Troger's base scaffold-based dyes for DSSC applications
  作者：Simona Urnikaite、Titas Braukyla、Artiom Magomedov、Egidijus Kamarauskas、Tadas Malinauskas、Vytautas Getautis

  DOI：10.1016/j.dyepig.2017.04.012

  日期：2017.8

  Three Troger's base scaffold-based metal-free sensitizers TD1, TD2 and TD3 with triphenylamine donor and rhodanine-3-acetic acid as an acceptor/anchoring group were designed and synthesized for dye-sensitized solar cells. The sensitizer series was designed to investigate the influence of the poly[n]enic (from n = 0 to 2) backbones and their anchoring effect in DSSCs. Optical, electrochemical and photovoltaic

  设计并合成了三种以Troger's支架为基础的无金属敏化剂TD1，TD2和TD3，其中三苯胺供体和罗丹宁-3-乙酸为受体/固定基团，用于染料敏化太阳能电池。敏化剂系列旨在研究多烯键（从n = 0到2）主链的影响及其在DSSC中的锚固作用。将光学，电化学和光伏性质与具有一个锚定基团的类似物染料D1-D3进行了比较。业已证明，延伸的聚次甲基链确保了这些单元的柔性，并激发了两个生色团之间的相互作用，从而促进了这些Troger碱基染料中聚集体的形成。
• [EN] beta -ALKOXYACRYLATES AGAINST MALARIA<br/>[FR] BETA-ALCOXYACRYLATES CONTRE LA MALARIA
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：WO1999002150A1

  公开（公告）日：1999-01-21

  (EN) The invention relates to the use of $g(b)-alkoxyacrylates of formulae (IA) or (IB) wherein R, R1, R6, R7, R8, X and Z are as defined herein, as therapeutically active substances, especially in the treatment or prophylaxis of malaria and to medicaments containing these substances.(FR) L'invention concerne l'utilisation de $g(b)-alcoxyacrylates de formule (IA) ou (IB), dans lesquelles R, R1, R6, R7, R8, X et Z sont conformes au descriptif, en tant que composants thérapeutiques actifs dans le traitement ou la prophylaxie de la malaria, ainsi que des médicaments contenant ces composants.

  本发明涉及使用公式（IA）或（IB）中R，R1，R6，R7，R8，X和Z如本文所定义的$g(b)-烷氧基丙烯酸酯作为治疗活性物质，特别是在治疗或预防疟疾方面的应用，以及包含这些物质的药物。
• MOLDED ARTICLE AND PRODUCTION METHOD THEREFOR
  申请人：Toray Industries, Inc.

  公开号：EP3653663A1

  公开（公告）日：2020-05-20

  The present invention addresses the problem of providing a fiber-reinforced composite material molded article which exhibits excellent viscosity stability with regards to a resin composition for coating at a low temperature (50°C) after mixing, takes a short period of time to cure when forming a coating, and has excellent surface appearance. This molded article has a coating formed by having a resin composition cure on the surface of a fiber-reinforced composite material. The resin composition contains [A] an aliphatic epoxy resin, [B] a thiol compound, and [C] a quaternary phosphonium salt.

  本发明要解决的问题是提供一种纤维增强复合材料模塑制品，该制品在低温（50°C）混合后，涂覆用树脂组合物的粘度稳定性极佳，形成涂层时固化时间短，且表面外观极佳。这种成型品的涂层是通过在纤维增强复合材料表面固化树脂组合物形成的。树脂组合物包含 [A] 脂肪族环氧树脂、[B] 硫醇化合物和 [C] 季鏻盐。
• Phenyl β-Methoxyacrylates:  A New Antimalarial Pharmacophore
  作者：Jawad Alzeer、Jacques Chollet、Ingrid Heinze-Krauss、Christian Hubschwerlen、Hugues Matile、Robert G. Ridley

  DOI：10.1021/jm990002y

  日期：2000.2.1

  Phenyl beta-methoxyacrylates, linked to an aromatic ring via an olefinic bridge, have been identified as novel, potentially inexpensive, antimalarial agents. The compounds are believed to exert their activity by inhibition of mitochondrial electron transport at the cytochrome bc(1) complex. A series of compounds have been synthesized to define structure-activity relationships affecting antimalarial activity. It was found that the beta-methoxyacrylate was required ortho to the linker and the optimal bridge was (E,E)-butadiene, Compounds in which the second aromatic ring was ortho-substituted or ortho,para-disubstituted gave optimal potency. Several compounds were identified with potency that is superior to that of chloroquine both in culture and in a murine malaria model.