(5-chloropentyl)diethylamine | 90652-31-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (5-chloropentyl)diethylamine
• 英文别名: 1-Chlor-5-diethylamino-pentan；5-Diaethylaminochlorpentan；5-Chlor-1-diethylamino-pentan；diethyl-(5-chloro-pentyl)-amine；5-Chlor-1-diaethylamino-pentan；Diaethyl-(5-chlor-pentyl)-amin；5-chloro-N,N-diethylpentan-1-amine
• CAS: 90652-31-6
• 化学式: C₉H₂₀ClN
• 分子量: 177.717
• InChiKey: PZUZOPPMNXFYFI-UHFFFAOYSA-N

物化性质

• 沸点：
  85-90 °C(Press: 12 Torr)
• 密度：
  0.907±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (5-chloropentyl)diethylamine 在 sodium sulfide 、 乙醇 作用下， 生成 bis-(5-diethylamino-pentyl)-sulfide
  参考文献：
  名称：

  Edwards et al., Journal of Pharmacy and Pharmacology, 1957, vol. 9, p. 1004,1007

  摘要：

  DOI：
• 作为产物：
  描述：

  5-氯代戊酰氯 在 lithium aluminium tetrahydride 作用下， 以 苯 为溶剂， 生成 (5-chloropentyl)diethylamine
  参考文献：
  名称：

  Solov'ev,V.M.; Skoldinov,A.P., Journal of general chemistry of the USSR, 1962, vol. 32, p. 432 - 438

  摘要：

  DOI：

文献信息

• 6,9-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines
  申请人：——

  公开号：US20030105098A1

  公开（公告）日：2003-06-05

  The present invention comprises 6-9-Disubstituted 2-[trans-(4-aminocyclohexyl]aminopurines that are useful in inhibiting cyclin dependent kinases, particularly cdk-2. The present invention also provides a method of preventing apoptosis in neuronal cells and a method of inhibiting the development of neoplasms.

  本发明涉及6-9-二取代的2- [转-（4-氨基环己基）]氨基嘌呤，其在抑制细胞周期依赖性激酶，特别是cdk-2方面具有用途。本发明还提供了一种预防神经细胞凋亡和抑制肿瘤发展的方法。
• Compositions providing improved functionalization of terminal anions and processes for improved functionalization of terminal anions
  申请人：——

  公开号：US20020010082A1

  公开（公告）日：2002-01-24

  Compositions including one or more anionic polymerization initiators and one or more additives for improving functionalizing efficiency of living polymer anions are disclosed. The present invention also provides compositions including one or more electrophiles and one or more additives for improving functionalizing efficiency of living polymer anions. Novel electrophiles and processes for improving polymer anion functionalization efficiencies are also disclosed.

  本发明公开了包括一种或多种阴离子聚合引发剂和一种或多种添加剂的组合物，用于提高活聚合物阴离子的官能化效率。本发明还提供了包括一种或多种亲电体和一种或多种添加剂的组合物，用于提高活聚合物阴离子的官能化效率。本发明还公开了用于提高聚合物阴离子官能化效率的新型亲电剂和工艺。
• Magidsson; Strukow, Archiv der Pharmazie, 1933, p. 574
  作者：Magidsson、Strukow

  DOI：——

  日期：——
• Hass; Huffman, Journal of the American Chemical Society, 1941, vol. 63, p. 1234
  作者：Hass、Huffman

  DOI：——

  日期：——
• Analogs of 8-[[6-(diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline as candidate antileishmanial agents
  作者：Maurice P. LaMontagne、Dinesh Dagli、M. Sami Khan、Peter Blumbergs

  DOI：10.1021/jm00183a004

  日期：1980.9

  8-[[6-(Diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline (I) has been shown to be highly effective against Leishmania donovani in hamsters, being approximately 475 times as active as the standard meglumine antimoniate. Several nuclear and side-chain analogues of I have been prepared in an attempt to further enhance the antileishmanial activity of this class of compounds. The compounds were tested against L. donovani in the golden hamster. Although several analogues had meglumine antimoniate indexes in excess of 300, none was superior to the model compound.