4-(1-butenyl)guaiacol | 85960-78-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-(1-butenyl)guaiacol
• 英文别名: 4-(but-1-en-1-yl)-2-methoxyphenol；4-[(E)-but-1-enyl]-2-methoxyphenol
• CAS: 85960-78-7
• 化学式: C₁₁H₁₄O₂
• 分子量: 178.231
• InChiKey: FJBDWWLIBKKDDT-SNAWJCMRSA-N

物化性质

• 沸点：
  283.0±20.0 °C(Predicted)
• 密度：
  1.052±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  n-propylmagnesium iodide 、 香草醛 以 乙醚 为溶剂， 生成 1-(4-hydroxy-3-methoxy-phenyl)-butan-1-ol 、 4-(1-butenyl)guaiacol
  参考文献：
  名称：

  Tobacco Smoke Chemistry. 2. Alkyl and Alkenyl Substituted Guaiacols Found in Cigarette Smoke Condensate.

  摘要：

  A series of alkyl and alkenyl substituted guaiacols, which comprise a group of biologically and organoleptically active compounds, have been synthesized. Mass spectra and GC retention times for these have been recorded and compared with those obtained for constituents of a weakly acidic fraction of smoke condensate derived from American blend type cigarettes. On the basis of these results, 25 guaiacols have been identified, 18 of which have not been detected in tobacco smoke condensate previously.

  DOI：

  10.3891/acta.chem.scand.43-0044

文献信息

• Controllable synthesis of 2- and 3-aryl-benzomorpholines from 2-aminophenols and 4-vinylphenols
  作者：Kui Dong、Xiao-Ling Jin、Shihao Chen、Li-Zhu Wu、Qiang Liu

  DOI：10.1039/d0cc02662j

  日期：——

  We present herein a method for the controllable synthesis of 3-aryl-benzomorpholine and 2-aryl-benzomorpholine cycloadducts via cross-coupling/annulation between electron-rich 2-aminophenols and 4-vinylphenols.

  我们在此提出一种方法，通过电子丰富的2-氨基酚和4-乙烯基酚之间的交叉偶联/环合反应，可控合成3-芳基-苯并吗啉和2-芳基-苯并吗啉环加成物。
• Reaction de wittig en milieu heterogene solide-liquide : transformation directe des aldehydes phenoliques naturels en alcenes
  作者：Yves Le Bigot、Michel Delmas、Antoine Gaset

  DOI：10.1016/s0040-4039(00)81363-5

  日期：1983.1

  New alkenylphenols can be obtained directly, without protecting the phenol group from the condensation reaction between phenolic aldehydes and various phosphonium salts in the presence of potassium carbonate in protic and aprotic media, using a solid-liquid phase transfer.

  在质子和非质子介质中，在碳酸钾的存在下，使用固-液相转移，可以直接获得新的烯基酚，而无需保护酚基不受酚醛与各种salts盐之间的缩合反应的影响。
• Sphingosine Kinase Inhibitors and Methods of Their Use
  申请人：Smith Charles D.

  公开号：US20100137315A1

  公开（公告）日：2010-06-03

  The invention relates to compounds, pharmaceutical compositions thereof, and methods for inhibiting sphingosine kinase and for treating or preventing hyperproliferative disease, inflammatory disease, or angiogenic disease.

  该发明涉及化合物，其制药组合物以及抑制鞘氨醇激酶和治疗或预防过度增生性疾病，炎症性疾病或血管生成性疾病的方法。
• Human therapeutic agents
  申请人：Ankh Life Sciences Limited

  公开号：US10751330B2

  公开（公告）日：2020-08-25

  Human therapeutic treatment compositions comprise at least two of a curcumin component, a harmine component, and an isovanillin component, and preferably all three in combination. The agents are effective for the treatment of human conditions, especially human cancers.

  人类治疗组合物包含姜黄素成分、禾本科成分和异香兰素成分中的至少两种，最好是三种成分的组合。这些制剂可有效治疗人类疾病，尤其是人类癌症。
• LE, BIGOT, Y.;DELMAS, M.;GASET, A., TETRAHEDRON LETT., 1983, 24, N 2, 193-196
  作者：LE, BIGOT, Y.、DELMAS, M.、GASET, A.

  DOI：——

  日期：——