tert-butyl N-[(2S)-1-(dimethylsulfamoylamino)-3,3-dimethylbutan-2-yl]carbamate | 848777-20-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: tert-butyl N-[(2S)-1-(dimethylsulfamoylamino)-3,3-dimethylbutan-2-yl]carbamate
• CAS: 848777-20-8
• 化学式: C₁₃H₂₉N₃O₄S
• 分子量: 323.457
• InChiKey: VDPUEIGOTDKROC-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  96.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  tert-butyl N-[(2S)-1-(dimethylsulfamoylamino)-3,3-dimethylbutan-2-yl]carbamate 、 碘甲烷 在 caesium carbonate 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 1.5h， 以91%的产率得到tert-butyl N-[(2S)-1-[dimethylsulfamoyl(methyl)amino]-3,3-dimethylbutan-2-yl]carbamate
  参考文献：
  名称：

  [EN] COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE
  [FR] NOUVEAUX COMPOSES EN TANT QU'INHIBITEURS DE LA PROTEASE SERINE NS3 DU VIRUS DE L'HEPATITE C

  摘要：

  公开号：

  WO2005087721A3
• 作为产物：
  描述：

  二甲胺基磺酰氯 、 [(2S)-1-氨基-3,3-二甲基-2-丁烷基](2-甲基-2-丙基)氨基甲酸 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以58%的产率得到tert-butyl N-[(2S)-1-(dimethylsulfamoylamino)-3,3-dimethylbutan-2-yl]carbamate
  参考文献：
  名称：

  [EN] COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE
  [FR] NOUVEAUX COMPOSES EN TANT QU'INHIBITEURS DE LA PROTEASE SERINE NS3 DU VIRUS DE L'HEPATITE C

  摘要：

  公开号：

  WO2005087721A3

文献信息

• Novel compounds as inhibitors of hepatitis C virus NS3 serine protease
  申请人：Venkatraman Srikanth

  公开号：US20070049536A1

  公开（公告）日：2007-03-01

  The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
• Macrocyclic Inhibitors of Hepatitis C Virus NS3 Serine Protease
  申请人：Venkatraman Srikanth

  公开号：US20110150835A1

  公开（公告）日：2011-06-23

  The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
• US7592419B2
  申请人：——

  公开号：US7592419B2

  公开（公告）日：2009-09-22
• US7718691B2
  申请人：——

  公开号：US7718691B2

  公开（公告）日：2010-05-18
• [EN] NOVEL COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE<br/>[FR] NOUVEAUX COMPOSES EN TANT QU'INHIBITEURS DE LA PROTEASE SERINE NS3 DU VIRUS DE L'HEPATITE C
  申请人：SCHERING CORP

  公开号：WO2005087721A2

  公开（公告）日：2005-09-22

  The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.