(S)-4,5,6,4',5',6'-hexamethoxybiphenyl-2,2'-dimethane | 911822-63-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 单宁
• 英文名称: (S)-4,5,6,4',5',6'-hexamethoxybiphenyl-2,2'-dimethane
• 英文别名: 1,2,3-Trimethoxy-5-methyl-4-(2,3,4-trimethoxy-6-methylphenyl)benzene
• CAS: 911822-63-4
• 化学式: C₂₀H₂₆O₆
• 分子量: 362.423
• InChiKey: MFBNRJSMYWMOBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  55.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (S)-4,5,6,4',5',6'-hexamethoxybiphenyl-2,2'-dimethane 在 吡啶 、 溴 作用下， 以 氯仿 为溶剂， 反应 0.5h， 以100%的产率得到(S)-3,3'-dibromo-4,5,6,4',5',6'-hexamethoxybiphenyl-2,2'-dimethane
  参考文献：
  名称：

  EP1870403

  摘要：

  公开号：
• 作为产物：
  描述：

  6,6'-bis(bromomethyl)l-2,2',3,3',4,4'-hexamethoxybiphenyl 在 lithium aluminium tetrahydride 、 盐酸 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 4.0h， 生成 (S)-4,5,6,4',5',6'-hexamethoxybiphenyl-2,2'-dimethane
  参考文献：
  名称：

  EP1870403

  摘要：

  公开号：

文献信息

• Anodic Phenol-Arene Cross-Coupling Reaction on Boron-Doped Diamond Electrodes
  作者：Axel Kirste、Gregor Schnakenburg、Florian Stecker、Andreas Fischer、Siegfried R. Waldvogel

  DOI：10.1002/anie.200904763

  日期：2010.1.25

  Particularly sustainable: The anodic cross‐coupling reaction between phenols and arenes can be performed on boron‐doped diamond electrodes. The arylated products are formed directly and obtained, in some cases, with high selectivity. Since only hydrogen atoms are sacrificed in the course of reaction this methodology opens the door to a novel concept for biaryl formation.

  特别可持续：可以在掺硼金刚石电极上进行苯酚和芳烃之间的阳极交叉偶联反应。芳基化的产物直接形成并在某些情况下以高选择性获得。由于在反应过程中仅氢原子被牺牲，因此该方法为联芳基形成的新概念打开了大门。
• PROCESS FOR PRODUCTION OF MONO-SUBSTITUTED ALKYLATED COMPOUND USING ALDIMINE OR DERIVATIVE THEREOF
  申请人：Maruoka Keiji

  公开号：US20090054679A1

  公开（公告）日：2009-02-26

  The present invention provides a method for producing asymmetrical mono-substituted alkylated compounds of α-amino acids that are represented by a specific formula, using an aldimine-type Schiff base. In the method of the present invention, the process of alkylating an aldimine-type Schiff base in a medium in the presence of an optically-active quaternary ammonium salt phase-transfer catalyst and an inorganic base is initiated, and subsequently the reaction is quenched at a time earlier than a time for completion of the stoichiometric reaction of the alkylation reaction, so that a mono-substituted alkylated product with high optical purity can be obtained.

  本发明提供了一种使用醛亚胺型席夫碱制备α-氨基酸的不对称单取代烷基化合物的方法，其由特定的公式表示。在本发明的方法中，通过在存在光学活性季铵盐相转移催化剂和无机碱的介质中烷基化醛亚胺型席夫碱的过程，随后在达到化学计量反应完成时间之前的时间中止反应，从而可以获得具有高光学纯度的单取代烷基化产物。
• OPTICALLY ACTIVE QUATERNARY AMMONIUM SALT HAVING AXIAL ASYMMETRY AND PROCESS FOR PRODUCING -AMINO ACID AND DERIVATIVE THEREOF WITH THE SAME
  申请人：NAGASE & COMPANY, LTD.

  公开号：EP1870403A1

  公开（公告）日：2007-12-26

  The present invention provides a chiral phase-transfer catalyst of the following formula (I): The compound (I) can be produced by reacting a 2,2'-dimethylene bromide-1,1'-biphenyl derivative, which can be produced through comparatively small number of steps, with an easily available secondary amine.

  本发明提供了下式（I）的手性相转移催化剂： 化合物(I)可通过 2,2'-二亚甲基溴-1,1'-联苯衍生物与易得的仲胺反应制得，该衍生物可通过相对较少的步骤制得。
• Optically active quaternary ammonium salt having axial asymmetry and process for producing alpha-amino acid and derivative thereof with the same
  申请人：NAGASE & COMPANY, LTD.

  公开号：EP2484667A1

  公开（公告）日：2012-08-08

  The present invention provides a chiral phase-transfer catalyst of the following formula (I): The compound (I) can be produced by reacting a 2,2'-dimethylene bromide-1,1'-biphenyl derivative, which can be produced through comparatively small number of steps, with an easily available secondary amine.

  本发明提供了下式（I）的手性相转移催化剂： 化合物(I)可通过 2,2'-二亚甲基溴-1,1'-联苯衍生物与易得的仲胺反应制得，该衍生物可通过相对较少的步骤制得。
• OPTICALLY ACTIVE QUATERNARY AMMONIUM SALT HAVING AXIAL ASYMMETRY AND PROCESS FOR PRODUCING ALPHA-AMINO ACID AND DERIVATIVE THEREOF WITH THE SAME
  申请人：Maruoka Keiji

  公开号：US20090270614A1

  公开（公告）日：2009-10-29

  The present invention provides a chiral phase-transfer catalyst of the following formula (I): The compound (I) can be produced by reacting a 2,2′-dimethylene bromide-1,1′-biphenyl derivative, which can be produced through comparatively small number of steps, with an easily available secondary amine.