(2-hydroxynaphth-1-yl)-diphenylmethanol | 74424-80-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (2-hydroxynaphth-1-yl)-diphenylmethanol
• 英文别名: <1-(2-hydroxynaphthyl)>diphenylmethanol；1-(hydroxydiphenylmethyl)naphthalen-2-ol；(2-Hydroxy-[1]naphthyl)-diphenyl-methanol；2-Oxy-1-(α-oxy-benzhydryl)-naphthalin；1-(α-Oxy-benzhydryl)-naphthol-(2)；Diphenyl-(2-oxy-naphthyl-(1))-carbinol；1-[Hydroxy(diphenyl)methyl]naphthalen-2-ol
• CAS: 74424-80-9
• 化学式: C₂₃H₁₈O₂
• 分子量: 326.395
• InChiKey: PTPWMMBHHSNZFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2-hydroxynaphth-1-yl)-diphenylmethanol 以 溶剂黄146 为溶剂， 以30%的产率得到12-phenyl-12H-benzo[a]xanthene
  参考文献：
  名称：

  Solid-state dehydration of (o-hydroxyaryl)diphenylmethanols. Crystal and molecular structures of [1-(2-hydroxyphenyl)]diphenylmethanol and of [1-(2-hydroxynaphthyl)]diphenylmethanol

  摘要：

  DOI：

  10.1021/ja00534a016
• 作为产物：
  描述：

  二氯二苯甲烷 在 二硫化碳 、 sodium hydroxide 、 三氯化铝 作用下， 生成 (2-hydroxynaphth-1-yl)-diphenylmethanol
  参考文献：
  名称：

  Gomberg; Sullivan, Journal of the American Chemical Society, 1920, vol. 42, p. 1868

  摘要：

  DOI：

文献信息

• Development of a Photolabile Carbonyl-Protecting Group Toolbox
  作者：Haishen Yang、Xin Zhang、Lei Zhou、Pengfei Wang

  DOI：10.1021/jo102429g

  日期：2011.4.1

  New salicyl alcohol derived photolabile carbonyl protecting groups have been developed, and the effect of substituents on the photochemical properties of photolabile protecting groups (PPGs) has been studied. The 3-(dimethylamino)phenyl groups at the α position prove to be important to the efficiency of the deprotection reactions, as shown in the photo reactions of the acetal 9. On the other hand,

  已经开发了新的水杨醇衍生的光不稳定的羰基保护基，并且已经研究了取代基对光不稳定的保护基（PPG）的光化学性质的影响。如在乙缩醛9的光反应中所示，在α位置的3-（二甲基氨基）苯基被证明对于脱保护反应的效率是重要的。。另一方面，将水杨醇的苯骨架扩展为萘并不能改善PPG的光化学性质。中性保护方案已推广到具有α，α-二芳基水杨醇骨架的新型PPG。因此，在不使用任何其他化学试剂的情况下，可以轻松地在140°C下将PPG安装在醛上。这些PPG在典型的水解乙缩醛的酸性条件下稳定，并与传统的羰基化合物的1,3-二恶烷/ 1,3-二恶戊环构成正交保护基。已经证明了碳水化合物分子的高效释放，其对于碳水化合物的位点特异性释放和固定化对于制备高密度微阵列可能潜在有用。借助丰富的PPG工具箱，PPG根据其紫外线吸收曲线分为三个亚组。来自不同亚组的PPG可以通过使用不同的紫外线照射波长顺序去除。对于吸收UVA（λ> 315
• Dearomative Cyclopropanation of Naphthols via Cyclopropene Ring‐Opening
  作者：Rachel J. Baker、Justin Ching、Teh Ren Hou、Ivan Franzoni、Mark Lautens

  DOI：10.1002/anie.202116171

  日期：2022.2.14

  The rhodium- and acid-catalyzed dearomative cyclopropanation of naphthols from cyclopropene ring-opening has been described. The reaction is scalable and highly chemoselective, and the vinyl cyclopropane products can be uniquely diversified. Experimental and computational studies support the proposed mechanism.

  已经描述了由环丙烯开环的萘酚的铑和酸催化的脱芳环丙烷化。该反应具有可扩展性和高度化学选择性，并且乙烯基环丙烷产品可以独特地多样化。实验和计算研究支持所提出的机制。
• Use of triaryl methane compounds for inhibiting unwanted cellular proliferation associated with inflammatory disease
  申请人：——

  公开号：US20020119953A1

  公开（公告）日：2002-08-29

  The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation, and in particular inflammatory diseases associated with unwanted cellular proliferation. The active compounds are substituted triaryl methane compounds or analogues thereof where one or more of the aryl groups is replaced with a heteroaryl, cycloalkyl or heterocycloalkyl group and/or the tertiary carbon atom is replaced with a different atom such as Si, Ge, N or P. the compounds inhibit mammalian cell proliferation, inhibit the Gardos channel of erythrocytes, reduce sickle erythrocyte dehydration and/or delay the occurrence of erythrocyte sickling or deformation.

  本发明提供了一类化合物，可作为治疗镰状细胞病和以不需要的或异常的细胞增殖为特征的疾病，特别是与不需要的细胞增殖有关的炎症性疾病的有效药物。这些活性化合物是取代的三芳基甲烷化合物或其类似物，其中一个或多个芳基被杂芳基、环烷基或杂环烷基取代，和/或三级碳原子被不同的原子如 Si、Ge、N 或 P 取代。这些化合物可抑制哺乳动物细胞增殖，抑制红细胞的加多斯通道，减少镰状红细胞脱水和/或延缓红细胞镰状化或变形的发生。
• Method for reducing chloride secretion by intestinal epithelial cells in situ: use of triaryl methane compounds
  申请人：——

  公开号：US20030119784A1

  公开（公告）日：2003-06-26

  A method and product for treating and preventing diarrhea and scours is provided. The method involves treating a subject who has diarrhea, or scours, or is at risk of getting diarrhea or scours with an aromatic compound of the invention. The products of the invention are a veterinary preparation of the aromatic compound of the invention and an anti-scours agent, and a pharmaceutical preparation of the aromatic compound of the invention and an anti-diarrheal agent.

  本发明提供了一种治疗和预防腹泻和溃疡的方法和产品。该方法包括用本发明的芳香族化合物治疗腹泻、或溃疡、或有腹泻或溃疡风险的受试者。本发明的产品是本发明芳香族化合物和抗溃疡剂的兽用制剂，以及本发明芳香族化合物和抗腹泻剂的药用制剂。
• Grover, Arvinder; Ray, Suprabhat, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1994, vol. 33, p. 243 - 246
  作者：Grover, Arvinder、Ray, Suprabhat

  DOI：——

  日期：——