methyl cyclohexanecarboximidate hydrochloride | 94052-40-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 甲亚胺酸及其衍生物
• 英文名称: methyl cyclohexanecarboximidate hydrochloride
• 英文别名: Methyl Cyclohexanecarbimidate Hydrochloride；methyl cyclohexanecarboximidate;hydrochloride
• CAS: 94052-40-1
• 化学式: C₈H₁₅NO*ClH
• 分子量: 177.674
• InChiKey: MULCMQSKQIZSRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.61
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  33.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  methyl cyclohexanecarboximidate hydrochloride 在 水 作用下， 生成 环己甲酸甲酯
  参考文献：
  名称：

  Ketene Acetals. XXXIV. Tetra- and Pentamethylene Ketene Acetals

  摘要：

  DOI：

  10.1021/ja01622a040
• 作为产物：
  描述：

  (5R,6E,8E,10E,13S,14S,15R,16Z)-15-羟基-5-甲氧基-14,16-二甲基-3,22,24-三羰基-2-氮杂二环[18.3.1]二十四碳-1(23),6,8,10,16,20-六烯-13-基N-(环己基羰基)-D-丙氨酸酸酯 在 盐酸 、 Pd/SrCO₃ 、 乙醚 、 乙酸酐 作用下， 生成 methyl cyclohexanecarboximidate hydrochloride
  参考文献：
  名称：

  Ketene Acetals. XXXIV. Tetra- and Pentamethylene Ketene Acetals

  摘要：

  DOI：

  10.1021/ja01622a040

文献信息

• Oxidation of Oxazolines and Thiazolines to Oxazoles and Thiazoles. Application of the Kharasch−Sosnovsky Reaction
  作者：A. I. Meyers、Francis X. Tavares

  DOI：10.1021/jo9613491

  日期：1996.11.15

  Kharasch-Sosnovsky reaction, the oxidation of oxazolines and thiazolines bearing a variety of 2-alkyl substituents (chiral and achiral) were smoothly oxidized to their corresponding oxazoles and thiazoles, respectively. The key feature involved in the successful implementation of this important oxidation was the use of a mixture of Cu(I) and Cu(II) salts to enhance the oxidation of the intermediate captodative

  使用Kharasch-Sosnovsky反应的改进，将带有各种2-烷基取代基（手性和非手性）的恶唑啉和噻唑啉的氧化分别平滑地氧化为相应的恶唑和噻唑。成功实施此重要氧化反应的关键特征是使用Cu（I）和Cu（II）盐的混合物来增强中间俘虏性自由基的氧化作用24。氧化失败的原因是在C-4处缺少碳烷氧基的恶唑啉/噻唑啉。
• Heterocyclic amplifiers of phleomycin. IV. Pyrimidinylpurines, phenylpyrimidines and related systems with basic side chains
  作者：DJ Brown、S Lan、K Mori

  DOI：10.1071/ch9842093

  日期：——

  Syntheses of 4,5,6-triamino-2,4'-bipyrimidines and subsequent conversions into 6-amino-2-pyrimidinylpurine-8-thiones, and their S-dimethylaminoethyl derivatives, are described; routes to a series of cyclohexyl- and piperidino-pyrimidines bearing a sulfur-linked side chain, as well as to phenyl- and methyl-pyrimidines bearing two such side chains, are also described. As amplifiers of phleomycin in a bacterial screen, the above purines proved poor, the cyclohexyl- and piperidinopyrimidines showed medium activities, and the phenylpyrimidines with two side chains (but not the analogous methylpyrimidines) exhibited very high activities.

  合成 4,5,6-三氨基-2,4'-联嘧啶及随后转化为 6-氨基-2-嘧啶基嘌呤-8-硫代物及其 S-二甲基氨基乙基 及其 S-二甲基氨基乙基衍生物的路线；描述了一系列环己基和哌啶基嘧啶的 嘧啶的一系列环己基和哌啶基嘧啶的制备路线。 还介绍了一系列带有硫键侧链的环己基和哌啶基嘧啶，以及带有两条硫键侧链的苯基和甲基嘧啶的制备方法。 描述。在细菌筛选过程中，上述嘌呤类化合物被证明不能作为博来霉素的扩增剂。 的活性较差，环己基和哌啶基嘧啶的活性中等、 而具有两个侧链的苯基嘧啶（而不是类似的甲基嘧啶 甲基嘧啶）表现出极高的活性。
• NEW IMIDAZOLONE DERIVATIVES, PREPARATION THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS PROTEIN KINASE INHIBITORS, IN PARTICULAR CDC7
  申请人：Leroy Vincent

  公开号：US20090253679A1

  公开（公告）日：2009-10-08

  The present invention relates to imidazolone derivatives of formula (I) to methods of preparing such derivatives, intermediates thereto, pharmaceutical compositions comprising such derivatives, and methods of inhibiting protein kinase, and methods of treatment comprising administration of such derivatives.

  本发明涉及式(I)的咪唑酮衍生物，涉及制备这种衍生物的方法、中间体、包含这种衍生物的药物组合物、抑制蛋白激酶的方法以及包括给予这种衍生物的治疗方法。
• A Facile and Versatile Route to 2-Substituted-4(3H)-Quinazolinones and Quinazolines
  作者：David J. Connolly、Patrick J. Guiry

  DOI：10.1055/s-2001-18080

  日期：——

  A range of 2-aryl and 2-alkyl quinazolinones have been prepared in moderate to good yields from the reaction of anthranilic acid and the appropriately substituted imidate in a facile, mild, one-pot procedure. Subsequent reaction with phosphorus oxychloride afforded the corresponding 4-chloro-2-substituted quinazolines, which are useful synthetic intermediates, in good to high yields. Product isolation was facilitated by the development of work up procedures for both reactions that did not include purification by column chromatography.

  通过简单、温和的一锅式反应，我们从蚁酸和适当取代的亚胺酯反应中制备出了一系列 2-芳基和 2-烷基喹唑啉酮，收率从中等到良好。随后与氧氯化磷反应，可以得到相应的 4-氯-2-取代喹唑啉类化合物，它们是有用的合成中间体，收率从好到高。为这两个反应开发的工作程序不包括柱层析纯化，从而促进了产品的分离。
• Weidinger,H.; Kranz,J., Chemische Berichte, 1963, vol. 96, p. 1049 - 1058
  作者：Weidinger,H.、Kranz,J.

  DOI：——

  日期：——