N-(4-chlorophenyl)-2-naphthalenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(4-chlorophenyl)-2-naphthalenesulfonamide
• 英文别名: N-4-chlorophenyl-2-naphthalenesulfonamide；naphthalene-2-sulfonic acid-(4-chloro-anilide)；Naphthalin-2-sulfonsaeure-(4-chlor-anilid)；N-(4-chlorophenyl)naphthalene-2-sulfonamide
• 化学式: C₁₆H₁₂ClNO₂S
• 分子量: 317.796
• InChiKey: MXPQZLLZPPVBMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-phenylnaphthalene-2-sulfonamide 在 氯 、 1,1,2,2-四氯乙烷 作用下， 生成 N-(4-chlorophenyl)-2-naphthalenesulfonamide
  参考文献：
  名称：

  Schuloff; Pollak; Riess, Chemische Berichte, 1929, vol. 62, p. 1853

  摘要：

  DOI：

文献信息

• Direct Conversion of Thiols to Sulfonyl Chlorides and Sulfonamides
  作者：Kiumars Bahrami、Mohammad M. Khodaei、Mehdi Soheilizad

  DOI：10.1021/jo901924m

  日期：2009.12.18

  H2O2 in combination with SOCl2 proved to be it highly reactive reagent for the direct oxidative conversion of thiol derivatives to the corresponding sulfonyl chlorides with high purity through oxidative chlorination. Upon reaction with amines, the corresponding sulfonamides were obtained in excellent yields and in very short reaction times.
• Direct conversion of thiols and disulfides into sulfonamides
  作者：Kiumars Bahrami、Mohammad M. Khodaei、Mehdi Soheilizad

  DOI：10.1016/j.tetlet.2010.07.056

  日期：2010.9

  The H(2)O(2)-ZrCl(4) reagent system is used as a new and efficient reagent for the conversion of thiols and disulfides into sulfonamides. The protocol offers several advantages such as excellent yields of products and extremely fast reactions at room temperature. The reagent system is very easy to handle and is environmentally safe and economical. (C) 2010 Elsevier Ltd. All rights reserved.
• Schuloff; Pollak; Riess, Chemische Berichte, 1929, vol. 62, p. 1853
  作者：Schuloff、Pollak、Riess

  DOI：——

  日期：——