(4-methoxyphenyl)(4-hydroxyphenyl)(naphth-1-yl)methane | 586949-83-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (4-methoxyphenyl)(4-hydroxyphenyl)(naphth-1-yl)methane
• 英文别名: (4-methoxyphenyl)(4-hydroxyphenyl)(1-naphthyl)methane；(4-methoxyphenyl)-(4-hydroxyphenyl)-naphth-1-yl-methane；4-[(4-methoxyphenyl)-naphthalen-1-ylmethyl]phenol
• CAS: 586949-83-9
• 化学式: C₂₄H₂₀O₂
• 分子量: 340.422
• InChiKey: VMDQDRRCUUOYJE-UHFFFAOYSA-N

物化性质

• 熔点：
  140 °C
• 沸点：
  522.3±38.0 °C(Predicted)
• 密度：
  1.176±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (4-methoxyphenyl)(4-hydroxyphenyl)(naphth-1-yl)methane 在 镍 氢气 、 potassium carbonate 作用下， 以 甲醇 为溶剂， 120.0 ℃ 、344.74 kPa 条件下， 生成 (4-methoxyphenyl)[4-(2,3-epoxypropyloxy)phenyl](1,2,3,4-tetrahydronaphth-1-yl)methane
  参考文献：
  名称：

  Diaryl naphthyl methanes a novel class of anti-implantation agents

  摘要：

  Diaryl naphthyl methanes and the corresponding 1, 2, 3, 4- and 5, 6, 7, 8-tetrahydro naphthyl methane derivatives have been synthesized as novel estrogen receptor binding ligands. The secondary and tertiary amino alkoxy derivatives of diaryl naphthyl and tetrahydro naphthyl methane interact with the estrogen receptor to elicit promising estrogenic, antiestrogenic and implantation inhibition activities in rats. The most active compounds in this series are 7, 9 and 20, cent percent active in preventing implantation in rats at 2.5 mgkg(-1) dose. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.12.015
• 作为产物：
  描述：

  (4-methoxyphenyl)(naphthalen-1-yl)methanone 在 sodium tetrahydroborate 、 三氯化铝 、 四氯化钛 作用下， 以 甲醇 、 正戊烷 、 苯 为溶剂， 生成 (4-methoxyphenyl)(4-hydroxyphenyl)(naphth-1-yl)methane
  参考文献：
  名称：

  Diaryl naphthyl methanes a novel class of anti-implantation agents

  摘要：

  Diaryl naphthyl methanes and the corresponding 1, 2, 3, 4- and 5, 6, 7, 8-tetrahydro naphthyl methane derivatives have been synthesized as novel estrogen receptor binding ligands. The secondary and tertiary amino alkoxy derivatives of diaryl naphthyl and tetrahydro naphthyl methane interact with the estrogen receptor to elicit promising estrogenic, antiestrogenic and implantation inhibition activities in rats. The most active compounds in this series are 7, 9 and 20, cent percent active in preventing implantation in rats at 2.5 mgkg(-1) dose. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.12.015

文献信息

• Synthetic approach towards trisubstituted methanes and a chiral tertiary α-hydroxyaldehyde, a possible intermediate for tetrasubstituted methanes
  作者：Priyanka Singh、Subal Kumar Dinda、Shagufta、Gautam Panda

  DOI：10.1039/c3ra41826j

  日期：——

  spacer between the central methano-carbon and benzene ring, is reported. In an approach towards asymmetric tetrasubstituted methane with high enantioselectivity, chiral tertiary α-hydroxyaldehyde has been synthesized through a Sharpless dihydroxylation on a disubstituted olefin, followed by the chemoselective oxidation of the primary alcohol.

  据报道，一系列含有芳基和杂芳基环的三取代甲烷，以及在中心甲烷碳和苯环之间的硫间隔基。在一种具有高对映选择性的不对称四取代甲烷的方法中，通过在二取代烯烃上进行无尖锐的二羟基化反应，然后对伯醇进行化学选择性氧化，合成了手性叔α-羟基醛。
• The Effect of Co‐catalyst in the Friedel–Crafts Reaction in Synthesis of Diaryl‐naphth‐1‐yl‐methane Derivatives
  作者：S. Ray、Neeta Srivastava、Sangita、Atul Kumar

  DOI：10.1081/scc-120039487

  日期：2004.1.1

  Abstract Synthesis of substituted diaryl‐naphth‐1‐yl‐methane has been carried out by Friedel–Crafts reaction of aryl naphth‐1‐yl methanol with substituted phenols. During the course of this reaction using AlCl3 as catalyst some rearrangements occurred, resulting in the formation of a complex mixture of products. Use of CTMS, ZrCl4, and SnCl4 as a co‐catalyst in combination with AlCl3 enhanced the formation

  摘要 通过芳基萘-1-基甲醇与取代酚的Friedel-Crafts反应合成了取代的二芳基-萘-1-基甲烷。在使用 AlCl3 作为催化剂的反应过程中，发生了一些重排，导致形成复杂的产物混合物。使用 CTMS、ZrCl4 和 SnCl4 作为助催化剂与 AlCl3 结合增强了对烷基化产物的形成。#CDRI 通讯编号 5602。
• Process for the preparation of diaryl naphthyl methanes
  申请人：Council of Scientific and Industrial Research

  公开号：US06610705B1

  公开（公告）日：2003-08-26

  The invention relates to novel diaryl naphthyl methane compounds having general formula I as shown herein below, and said compounds useful in the treatment of esterogen related disease or syndrome, Pharmaceutical compositions comprising said novel methane derivatives, process for the preparation of the novel methane derivatives and methods for the treatment of esterogen related diseases or syndrome.

  本发明涉及一种新型二芳基萘甲烷化合物，其通式如下所示，所述化合物可用于治疗雌激素相关疾病或综合征，包括含有该新型甲烷衍生物的制药组合物，制备该新型甲烷衍生物的方法以及治疗雌激素相关疾病或综合征的方法。
• US6610705B1
  申请人：——

  公开号：US6610705B1

  公开（公告）日：2003-08-26
• Diaryl naphthyl methanes a novel class of anti-implantation agents
  作者：Neeta Srivastava、Sangita、S Ray、M.M Singh、Anila Dwivedi、Atul Kumar

  DOI：10.1016/j.bmc.2003.12.015

  日期：2004.3

  Diaryl naphthyl methanes and the corresponding 1, 2, 3, 4- and 5, 6, 7, 8-tetrahydro naphthyl methane derivatives have been synthesized as novel estrogen receptor binding ligands. The secondary and tertiary amino alkoxy derivatives of diaryl naphthyl and tetrahydro naphthyl methane interact with the estrogen receptor to elicit promising estrogenic, antiestrogenic and implantation inhibition activities in rats. The most active compounds in this series are 7, 9 and 20, cent percent active in preventing implantation in rats at 2.5 mgkg(-1) dose. (C) 2004 Elsevier Ltd. All rights reserved.