1-溴-2-[氯(乙氧基)磷酰基]乙烷 | 122954-37-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 中文名称: 1-溴-2-[氯(乙氧基)磷酰基]乙烷
• 英文名称: ethyl β-bromoethylphosphonate acid chloride
• 英文别名: 2-bromoethyl-phosphonochloridic acid, ethyl ester；ethyl (2-bromoethyl)phosphonochloridate；1-bromo-2-[chloro(ethoxy)phosphoryl]ethane
• CAS: 122954-37-4
• 化学式: C₄H₉BrClO₂P
• 分子量: 235.445
• InChiKey: HNLZWYJWAHTCOM-UHFFFAOYSA-N

物化性质

• 沸点：
  75 °C(Press: 0.1 Torr)
• 密度：
  1.573±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,O-双三甲硅基乙酰胺 、 1-溴-2-[氯(乙氧基)磷酰基]乙烷 以49.4%的产率得到ethyl trimethylsilyl (2-bromoethyl)phosphonate
  参考文献：
  名称：

  Reaction of dibromoalkanes with silyl phosphites. Synthesis and properties of mono-and diphosphonoalkanes

  摘要：

  Reactions of dibromoethane and dibromopropane with silyl phosphites are studied. Mono- and diphosphonoalkanes of various structures were prepared, and their chemical properties were studied.

  DOI：

  10.1134/s1070363206050094
• 作为产物：
  描述：

  2-溴乙基膦酸二乙酯 在 五氯化磷 作用下， 以 四氯化碳 为溶剂， 反应 2.0h， 以85%的产率得到1-溴-2-[氯(乙氧基)磷酰基]乙烷
  参考文献：
  名称：

  Gubnitskaya, E. S.; Peresypkina, L. P., Journal of general chemistry of the USSR, 1989, vol. 59, # 31, p. 492 - 499

  摘要：

  DOI：

文献信息

• Experimental and theoretical investigation of intramolecular transformations of silicon-containing (haloalkyl)phosphorylated ureas and acylamides
  作者：M. A. Pudovik、G. A. Chmutova、L. K. Kibardina、S. A. Terent’eva、R. Kh. Bagautdinova、N. A. Khailova、R. M. Kamalov、A. N. Pudovik

  DOI：10.1134/s1070363206030078

  日期：2006.3

  Silicon-containing chloromethylphosphorylated ureas undergo transformation involving evolution of chlorotrimethylsilane and formation of 1,3,4-oxazaphospholes. Their analogs, silicon-containing phosphorylated acylamides, transform in another way, viz. by beta-cleavage to form the corresponding siloxyphosphonates. Quantum-chemical investigation of thermodynamic characteristics of these processes was carried out.
• A Convenient Method for the Synthesis of α-Functionalized Chlorophosphonic Esters
  作者：X. Morise、P. Savignac、J. C. Guillemin、J. M. Denis

  DOI：10.1080/00397919108019758

  日期：1991.3

  Alpha-Functionalized chlorophosphonic monoesters were easily prepared by a selective chlorination of the corresponding phosphonic diesters with phosphorus oxychloride.
• GUBNITSKAYA, E. S.;PERESYPKINA, L. P., ZH. OBSHCH. XIMII, 59,(1989) N, S. 556-564
  作者：GUBNITSKAYA, E. S.、PERESYPKINA, L. P.

  DOI：——

  日期：——
• MORISE, X.;SAVIGNAC, P.;GUILLEMIN, J. C.;DENIS, J. M., SYNTH. COMMUN., 21,(1991) N, C. 793-798
  作者：MORISE, X.、SAVIGNAC, P.、GUILLEMIN, J. C.、DENIS, J. M.

  DOI：——

  日期：——
• Reaction of dibromoalkanes with silyl phosphites. Synthesis and properties of mono-and diphosphonoalkanes
  作者：M. A. Pudovik、S. A. Terent’eva、L. K. Kibardina、A. N. Pudovik

  DOI：10.1134/s1070363206050094

  日期：2006.5

  Reactions of dibromoethane and dibromopropane with silyl phosphites are studied. Mono- and diphosphonoalkanes of various structures were prepared, and their chemical properties were studied.