四异丙基肼 | 172909-37-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 四异丙基肼
• 中文别名: 肼,四(1-甲基乙基)-
• 英文名称: tetraisopropylhydrazine
• 英文别名: Tetra-isopropylhydrazin；1,1,2,2-tetra(propan-2-yl)hydrazine
• CAS: 172909-37-4
• 化学式: C₁₂H₂₈N₂
• 分子量: 200.368
• InChiKey: FNAZKACFHIFWFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,1,2-triisopropylhydrazine 在 copper(l) iodide 、 nitrosyl hexafluorophosphate 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 2.0h， 生成 四异丙基肼
  参考文献：
  名称：

  9-(Diisopropylamino)-9-azabicyclo[3.3.1]nonane and Tetraisopropylhydrazine: Isolable Radical Cations from Hydrazines with Nearly Perpendicular Lone Pairs

  摘要：

  Cuprous iodide catalyzes the addition of isopropyl Grignard reagent to triisopropyldiazenium cation (6) to give tetraisopropylhydrazine (3), a reaction which produces mostly the hydride transfer and deprotonation products of 6 in its absence. 9-(Dusopropylamino)-9-azabicyclo[3.3.1]nonane (2), its 3-keto analogue (4), and 3 each give isolable radical cations. Crystal structures are reported for 2, 2(+)NO(3)(-),3(+)OTs(-)CH(3)CN, and 4. 2(+) has its isopropyl groups in different rotamers, and 3(+) is nearly isostructural with tetraisopropylethylene (11), with each isopropyl methyne hydrogen roughly bisecting the C(Me(2)) unit of an adjacent isopropyl group. The first dynamic NMR experiments reported on radicals demonstrate that 2(+) occupies the same conformation in solution as in the crystal, and allow rough estimation of the barriers for isopropyl group interconversion in 2(+) and 3(+) at similar to 11 kcal/mol. Cyclic voltammetry and photoelectron spectroscopic data are reported for 2 and 3.

  DOI：

  10.1021/ja00151a007

文献信息

• 一种四异丙基肼的制备方法
  申请人：天津希恩思生化科技有限公司

  公开号：CN109232301B

  公开（公告）日：2021-01-01

  本发明涉及一种四异丙基肼的制备方法，在‑78度下，将LDA、稳定剂和三异丙基肼在有机溶剂中混合后，升至室温并搅拌2小时，再降温至‑78度，加入CuI和2‑溴丙烷，升至室温继续搅拌至反应完成后，后处理纯化得到四异丙基肼；所述稳定剂为TMEDA。本发明方法由三异丙基肼不经过三异丙基偶氮正离子六氟磷酸盐，在正丁基锂存在下，与2‑溴丙烷反应一步制备得到四异丙基肼。文献方法两步反应的收率只有23%，而本发明方法的收率为32%。这种新的合成方法使制备路线缩短，同时由于避免使用昂贵的NOPF6，从而使目标化合物四异丙基肼的制备成本大幅降低。
• Kolodiazhnyi, Oleg I.; Golovatyi, Oleg R., Phosphorus, Sulfur and Silicon and the Related Elements, 1995, vol. 102, # 1-4, p. 133 - 142
  作者：Kolodiazhnyi, Oleg I.、Golovatyi, Oleg R.

  DOI：——

  日期：——
• �ber hochverzweigte aliphatische Verbindungen
  作者：F. Kuffner、W. Seifried

  DOI：10.1007/bf00897724

  日期：——
• A CROSS-LINKED PYRROLOBENZODIAZEPINE DIMER (PBD) DERIVATIVE AND ITS CONJUGATES
  申请人：Hangzhou DAC Biotech Co., Ltd.

  公开号：US20210169896A1

  公开（公告）日：2021-06-10

  The present invention relates to novel cross-linked cytotoxic agents, pyrrolobenzodiazepine dimer (PBD) derivatives, and their conjugates to a cell-binding molecule, a method for preparation of the conjugates and the therapeutic use of the conjugates.
• CONJUGATION OF A CYTOTOXIC DRUG WITH BIS-LINKAGE
  申请人：Hangzhou DAC Biotech Co., Ltd.

  公开号：US20210393790A1

  公开（公告）日：2021-12-23

  A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease. wherein “ ” is an optional bond; X, Y, Z 1 , and Z 2 are a functional group; m 1 and n are a integer; L 1 and L 2 are a linker.