1-(1-cyano-ethyl)-semicarbazide | 903640-39-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-(1-cyano-ethyl)-semicarbazide
• 英文别名: α-Semicarbazino-propionsaeure-nitril；1-(1-Cyan-aethyl)-semicarbazid；1-cyanoethyl-semicarbazide；(1-cyanoethylamino)urea
• CAS: 903640-39-1
• 化学式: C₄H₈N₄O
• mdl: MFCD19203843
• 分子量: 128.134
• InChiKey: ZWBGMHQFPHRDEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  90.9
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(1-cyano-ethyl)-semicarbazide 以 ethyl orthoformate 为溶剂， 生成 1-cyanoethyl-3-hydroxy-1,2,4-triazole
  参考文献：
  名称：

  Phosphorus esters of 1-cyanoethyl-1,2,4-triazol-3-ols

  摘要：

  本文披露了新的1,2,4-三唑类化合物的制备方法及其作为杀虫剂的活性成分的应用。这些三唑类化合物符合以下结构式：##STR1##其中R.sub.1代表C.sub.1-C.sub.6烷基，C.sub.1-C.sub.6烷氧基或C.sub.1-C.sub.6烷基硫醚基，R.sub.2代表C.sub.1-C.sub.6烷基，R.sub.3代表氢、氯、溴、C.sub.1-C.sub.6烷基、C.sub.1-C.sub.6烷基硫醚基、C.sub.3-C.sub.5烯基硫醚基或C.sub.3-C.sub.5炔基硫醚基，X代表氧或硫。

  公开号：

  US04172080A1
• 作为产物：
  描述：

  氢氰酸 、 acetaldehyde semicarbazone 生成 1-(1-cyano-ethyl)-semicarbazide
  参考文献：
  名称：

  Thiele; Bailey, Justus Liebigs Annalen der Chemie, 1898, vol. 303, p. 85

  摘要：

  DOI：

文献信息

• Bailey, Journal of the American Chemical Society, 1904, vol. 26, p. 1012
  作者：Bailey

  DOI：——

  日期：——
• Potential novel predictors of mortality in end-stage renal disease patients with sleep disorders
  作者：Robert L. Benz、Mark R. Pressman、Edward T. Hovick、Donald D. Peterson

  DOI：10.1016/s0272-6386(00)70039-4

  日期：2000.6

  Patients with end-stage renal disease (ESRD) have an annual mortality rate exceeding 20%, although some survive many years. The ESRD population has a high incidence of sleep disorders, including sleep apnea and periodic limb movements in sleep (PLMS), Sleep disorders result in sleep deprivation, which can negatively affect immune function and cardiovascular-related outcomes, common causes of death in patients with ESRD. This study examined predictors of mortality in patients with ESRD with sleep problems. Twenty-nine consecutive patients with ESRD reporting disrupted sleep or daytime sleepiness were studied by all-night polysomnography. All patients were followed up until death, transplantation, or study termination, Among the variables studied, including such previously reported predictors as serum albumin level, urea reduction ratio, and hematocrit, only the PLMS index (PLMSI), arousing PLMSI (APLMSI), and total number of arousals per hour of sleep significantly predicted mortality, The 20-month survival rate with a PLMSI less than 20 was greater than 90% versus 50% for a PLMSI of 20 or greater (exact log-rank, P = 0.007), For the deceased versus survivor groups, mean PLMSI was 119.1 versus 19.8 (P = 0.01) and APLMSI was 48.1 versus 7.8 (P = 0.00006), with a mean survival of 10.3 versus greater than 25.5 months, respectively (P = 0.001), Median survival of patients with a PLMSI greater than 80 was only 6 months, PLMSI, APLMSI, and total arousals per hour of sleep were strongly associated with mortality in patients with ESRD with sleep disorders independent of other factors and may be novel predictors of near-term mortality. (C) 2000 by the National Kidney Foundation, Inc.
• Thiele; Bailey, Justus Liebigs Annalen der Chemie, 1898, vol. 303, p. 85
  作者：Thiele、Bailey

  DOI：——

  日期：——
• Bailey; Knox, Journal of the American Chemical Society, 1907, vol. 29, p. 884
  作者：Bailey、Knox

  DOI：——

  日期：——
• Bailey; Acree, Chemische Berichte, 1900, vol. 33, p. 1531
  作者：Bailey、Acree

  DOI：——

  日期：——