α-naphthyl p-fluorophenyl sulphone | 117953-28-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: α-naphthyl p-fluorophenyl sulphone
• 英文别名: 1-[(4-fluorophenyl)sulfonyl]naphthalene；1-(4-fluoro-benzenesulfonyl)-naphthalene；1-(4-Fluorophenyl)sulfonylnaphthalene
• CAS: 117953-28-3
• 化学式: C₁₆H₁₁FO₂S
• 分子量: 286.327
• InChiKey: RIOSBVJQOUAROD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  α-naphthyl p-fluorophenyl sulphone 在 肼 作用下， 以 水 、 二甲基亚砜 为溶剂， 反应 24.0h， 以92%的产率得到1-[4-(1-naphthalenylsulfonyl)phenyl]hydrazine
  参考文献：
  名称：

  Isomerization-Free Sulfonylation and Its Application in the Synthesis of PHA-565272A

  摘要：

  FeCl3 catalyzed an isomerization-free Friedel-Crafts sulfonylation between 1-naphthalenesulfonyl chloride and halobenzenes. The coupled halide was then displaced using 35% hydrazine in DMSO to provide the Fischer indole precursor. Pure 5-chloro-2-pentanone was the key for a successful Grandberg modification of Fischer indole synthesis that effectively constructed both the indole core and side chain of the target molecule. The development of these methods enabled a rapid preparation of kilogram quantities of PHA-565272A.

  DOI：

  10.1021/op050208a
• 作为产物：
  描述：

  氟苯 、 1-萘磺酰氯 生成 α-naphthyl p-fluorophenyl sulphone
  参考文献：
  名称：

  Yoshii, Yoshihiro; Ito, Akiyoshi; Hirashima, Tsuneaki, Journal of the Chemical Society. Perkin transactions II, 1988, p. 777 - 782

  摘要：

  DOI：

文献信息

• Catalyst for carbonylating naphthalene mono- and disulfonates and process using said catalyst
  申请人：ENICHEM S.p.A.

  公开号：EP0601662A1

  公开（公告）日：1994-06-15

  A cobalt based catalyst, and the method for preparing it, are disclosed. The catalyst is obtained from the reaction between NaCo(CO)₄ and s-trichloro triazine and is advantageously used in the processes of carbonylation of naphthalene mono- and disulfonates in order to yield naphthalene esters and acids.

  本发明公开了一种基于钴的催化剂及其制备方法。该催化剂是通过NaCo(CO)₄和s-三氯三嗪的反应获得的，并且在萘单磺酸盐和萘二磺酸盐的羰基化过程中具有优越的应用，以产生萘酯和酸。
• Catalyst for carbonylating naphthalene mono- and disulfonates and
  申请人：Enichem S.p.A.

  公开号：US05344960A1

  公开（公告）日：1994-09-06

  A cobalt based catalyst, and the method for preparing it, are disclosed. The catalyst is obtained from the reaction between NaCo(CO).sub.4 and s-trichloro triazine and is advantageously used in the processes of carbonylation of naphthalene mono- and disulfonates in order to yield naphthalene esters and acids.

  本发明公开了一种基于钴的催化剂及其制备方法。该催化剂是通过NaCo(CO)4和s-三氯三嗪反应得到的，并且在萘单磺酸盐和萘二磺酸盐的羰基化过程中优势得到应用，以产生萘酯和酸。
• Yoshii, Yoshihiro; Ito, Akiyoshi; Hirashima, Tsuneaki, Journal of the Chemical Society. Perkin transactions II, 1988, p. 777 - 782
  作者：Yoshii, Yoshihiro、Ito, Akiyoshi、Hirashima, Tsuneaki、Shinkai, Seiji、Manabe, Osamu

  DOI：——

  日期：——
• US5344960A
  申请人：——

  公开号：US5344960A

  公开（公告）日：1994-09-06
• Isomerization-Free Sulfonylation and Its Application in the Synthesis of PHA-565272A
  作者：Thomas J. Fleck、Jiong Jack Chen、Cuong V. Lu、Kari J. Hanson

  DOI：10.1021/op050208a

  日期：2006.3.1

  FeCl3 catalyzed an isomerization-free Friedel-Crafts sulfonylation between 1-naphthalenesulfonyl chloride and halobenzenes. The coupled halide was then displaced using 35% hydrazine in DMSO to provide the Fischer indole precursor. Pure 5-chloro-2-pentanone was the key for a successful Grandberg modification of Fischer indole synthesis that effectively constructed both the indole core and side chain of the target molecule. The development of these methods enabled a rapid preparation of kilogram quantities of PHA-565272A.