2-methyl-N-[(4-phenylphenyl)methyl]propanamide | 1346433-26-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methyl-N-[(4-phenylphenyl)methyl]propanamide
• CAS: 1346433-26-8
• 化学式: C₁₇H₁₉NO
• 分子量: 253.344
• InChiKey: DJCPIDARISYPTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-氨基乙基联苯 、 异丁酸 在 三甲基铝 作用下， 以 甲苯 为溶剂， 反应 1.0h， 以76%的产率得到2-methyl-N-[(4-phenylphenyl)methyl]propanamide
  参考文献：
  名称：

  Trimethylaluminium-Facilitated Direct Amidation of Carboxylic Acids

  摘要：

  自由羧酸在三甲基铝和胺的存在下，以适中至高产率，在90摄氏度下经过1小时后转化为酰胺。

  DOI：

  10.1055/s-0030-1260982

文献信息

• Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
  申请人：Incyte Corporation

  公开号：US10639310B2

  公开（公告）日：2020-05-05

  The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

  本发明提供了杂芳基取代的吡咯并[2,3-b]吡啶和杂芳基取代的吡咯并[2,3-b]嘧啶，它们可以调节 Janus 激酶的活性，并可用于治疗与 Janus 激酶活性有关的疾病，例如包括免疫相关疾病、皮肤疾病、骨髓增生性疾病、癌症和其他疾病。
• USE OF MATRIX METALLOPROTEINASE INHIBITORS IN SKIN CARE
  申请人：Yu Betty

  公开号：US20090068255A1

  公开（公告）日：2009-03-12

  The application of matrix metalloproteinase (MMP) inhibitors to the skin inhibits the degradation of proteins found in the skin including collagen, elastin, and other basement membrane and extracellular matrix protein. MMP inhibitors may be used in both cosmetic compositions and pharmaceutical compositions for application to skin. MMP inhibitors are formulated with a cosmetically suitable vehicle or pharmaceutically acceptable excipient for application to the skin as creams, lotions, ointments, solutions, face masks, etc. As cosmetics, the inventive MMP inhibitor compositions are applied to the skin to prevent or reduce the appearance of wrinkles, pigmentation changes, loss of elasticity, or other effects associated with aging or sun damage. As pharmaceuticals, the inventive MMP inhibitor compositions may also be applied to the skin to treat or prevent a skin disease (e.g., proliferative disease, inflammatory disease).
• HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS
  申请人：Incyte Corporation

  公开号：US20190125750A1

  公开（公告）日：2019-05-02

  The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
• US9814722B2
  申请人：——

  公开号：US9814722B2

  公开（公告）日：2017-11-14
• Trimethylaluminium-Facilitated Direct Amidation of Carboxylic Acids
  作者：Jinshan Chen、SeungWon Chung、Daniel Uccello、Huiwon Choi、Justin Montgomery

  DOI：10.1055/s-0030-1260982

  日期：2011.9

  Free carboxylic acids are converted into amides in moderate to high yields in the presence of a stoichiometric amount of trimethylaluminium and amines at 90 ˚C after 1 hour.

  自由羧酸在三甲基铝和胺的存在下，以适中至高产率，在90摄氏度下经过1小时后转化为酰胺。