tetraphosphoric acid | 13813-62-2

• 分子结构分类: 无机化合物 - 均质非金属化合物 - 非金属氧阴离子化合物
• 英文名称: tetraphosphoric acid
• 英文别名: tetrapolyphosphoric acid；PPA；Tetraphosphate；[hydroxy(phosphonooxy)phosphoryl] phosphono hydrogen phosphate
• CAS: 13813-62-2
• 化学式: H₆O₁₃P₄
• 分子量: 337.935
• InChiKey: YDHWWBZFRZWVHO-UHFFFAOYSA-N

物化性质

• 熔点：
  34 °C
• 密度：
  1.8886 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  -5.4
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  217
• 氢给体数：
  6
• 氢受体数：
  13

反应信息

• 作为反应物：
  描述：

  tetraphosphoric acid 、 lithium hydroxide 以 水 为溶剂， 生成 lithium tetraphosphate * 99 H2O
  参考文献：
  名称：

  Quimby, O. T., Journal of Physical Chemistry, 1954, vol. 58, p. 603 - 618

  摘要：

  DOI：
• 作为产物：
  描述：

  phosphorus pentoxide 以 水 为溶剂， 生成 tetraphosphoric acid
  参考文献：
  名称：

  Rakusin, M. A.; Arseniew, A. A., 1923, vol. 47, p. 195 - 195

  摘要：

  DOI：
• 作为试剂：
  描述：

  水合氯醛 、 间氨基苯甲醚 在 盐酸 、 盐酸羟胺 、 sodium sulfate 、 tetraphosphoric acid 作用下， 反应 18.0h， 生成 6-甲氧基靛红
  参考文献：
  名称：

  6-Methoxy-N-alkyl Isatin Acylhydrazone Derivatives as a Novel Series of Potent Selective Cannabinoid Receptor 2 Inverse Agonists: Design, Synthesis, and Binding Mode Prediction

  摘要：

  Recently, we discovered and reported a series of N-alkyl isatin acylhydrazone derivatives that are potent CB2 agonists. Here, we describe a novel series of selective CB2 inverse agonists resulting from introduction of a methoxy moiety in position 6 of the isatin scaffold. These novel 6-methoxy-N-alkyl isatin acylhydrazone derivatives exhibited high CB2 functional activity and selectivity at human CB2. Compound 16 (MDA77) had high activity (EC50 = 5.82 nM) at CB2 and no activity at CB1. Compound 15 (MDA55) (K-i = 89.9 nM, EC50 = 88.2 nM at CB2) inhibited the effect of compound 1 (MDA7), a selective CB2 agonist, in an animal model of neuropathic pain. The molecular modeling study presented here represents a first study of CB2 based on the structure of beta(2)-adrenergic receptor. A ligand-based homology model of the CB2 binding site was developed, and on the basis of our results, we propose a general binding mode for this class of inverse agonists with CB2.

  DOI：

  10.1021/jm801353p

文献信息

• Anaesthetic composition containing a steroid of the 5.alpha.-pregnane
  申请人：Glaxo Laboratories Limited

  公开号：US03952031A1

  公开（公告）日：1976-04-20

  This invention relates to steroids of the pregnane and 19-norpregnane series having anaesthetic properties and compositions containing them. More particularly the present invention relates to such steroids having a variety of substituents in the 2.beta.-position, a 3.alpha.-hydroxy group and a 5.alpha.-hydrogen atom and esters and 20-ketals thereof. At the 11-position of such steroids is preferably either two hydrogen atoms or an oxo group. The compounds according to the invention may conveniently be prepared by reaction of an appropriate 2.alpha.,3.alpha.-epoxy-pregnane or 19-norpregnane with a reagent which introduces the desired 2.beta.-substituent and various modifications of the compound produced are described to produce compounds within the scope of the invention. The present invention provides compositions containing certain steroids of the pregnane and 19-norpregnane series and such compositions generally may be administered intravenously to induce anaesthesia, the invention providing methods of inducing anaesthesia.

  这项发明涉及具有麻醉特性的孕烷和19-去甲孕烷系列类固醇以及含有它们的组合物。更具体地，本发明涉及具有2.beta.-位上各种取代基、3.alpha.-羟基和5.alpha.-氢原子以及其酯和20-酮缩醛的类固醇。在这种类固醇的11位上最好是两个氢原子或一个酮基团。根据本发明的化合物可以通过将适当的2.alpha.,3.alpha.-环氧孕烷或19-去甲孕烷与引入所需的2.beta.-取代基的试剂反应来方便地制备，并描述了所产生化合物的各种修饰以制备属于本发明范围内的化合物。本发明提供了含有孕烷和19-去甲孕烷系列某些类固醇的组合物，这些组合物通常可通过静脉注射来诱导麻醉，本发明提供了诱导麻醉的方法。
• Cyclic sulphur compounds
  申请人：Burroughs Wellcome Co.

  公开号：US04012499A1

  公开（公告）日：1977-03-15

  Certain tricyclic thioxanthone-10,10-dioxide compounds each of which is substituted in the 1-,2-,3- or 4-position by a carboxyl or (5-tetrazolyl) group and each of which is optionally substituted in the 5-,6-,7- or 8-position by a second carboxyl or (5-tetrazolyl) group or a substituent selected from cyano, halogen, nitro, alkyl, alkoxy, acyl, amino, acylamino, thioalkyl, alkylsulphinyl and alkylsulphonyl, as well as salts, and optionally substituted esters and amides of the carboxyl substituted compounds and alkyl derivatives of the tetrazolyl substituted compounds, are useful for the relief or prophylaxis of allergic conditions.

  一些三环噻二氧杂蒽-10,10-二氧化物化合物，其中每个在1、2、3或4位被羧基或(5-四唑基)基取代，同时每个在5、6、7或8位可选择地被第二个羧基或(5-四唑基)基或氰基、卤素、硝基、烷基、烷氧基、酰基、氨基、酰胺基、硫代烷基、烷基砜基和烷基砜基等取代基取代，以及这些羧基取代化合物的盐、可选择地取代的酯和酰胺以及四唑基取代化合物的烷基衍生物，可用于缓解或预防过敏症状。
• Antidepressant and neuroleptic benzothiopyrano [2,3-c]-pyridines
  申请人：Roussel Uclaf

  公开号：US04350697A1

  公开（公告）日：1982-09-21

  Novel compounds selected from the group consisting of compounds of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen and alkyl of 1 or 5 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, halogen and methyl, R.sub.3, R.sub.4 and R.sub.5 are individually selected from the group consisting of hydrogen, halogen, alkyl of 1 to 5 carbon atoms, alkoxy of 1 to 3 carbon atoms, --NH.sub.2 and mono- and dialkylamino of 1 to 3 alkyl carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having antidepressant and neuroleptic activity and their preparation.

  从由公式##STR1##组成的化合物组中选择的新化合物，其中R.sub.1从氢和1或5个碳原子的烷基组成的组中选择，R.sub.2从氢、卤素和甲基组成的组中选择，R.sub.3、R.sub.4和R.sub.5分别从氢、卤素、1至5个碳原子的烷基、1至3个碳原子的烷氧基、--NH.sub.2和1至3个烷基碳原子的单烷基和双烷基氨基组成的组中选择，以及其非毒性、药学上可接受的酸盐，具有抗抑郁和神经阻滞活性，以及其制备。
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: P: MVol.C, 110, page 248 - 252
  作者：

  DOI：——

  日期：——
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Ca: MVol.B1, 112, page 253 - 255
  作者：

  DOI：——

  日期：——