sudan I | 40339-35-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: sudan I
• 英文别名: 1-(phenylazo)-2-naphthalenol；(E)-1-(2-phenyldiazen-1-yl)naphthalen-2-ol；(E)-1-(phenyldiazenyl)naphthalene-2-ol；trans-(2-hydroxy-1-naphthylazo)benzene；(E)-1-(phenyldiazenyl)naphthalen-2-ol；1-(phenylazo)-2-naphthol
• CAS: 40339-35-3
• 化学式: C₁₆H₁₂N₂O
• 分子量: 248.284
• InChiKey: MRQIXHXHHPWVIL-ISLYRVAYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.96
• 重原子数：
  19.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  44.95
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  sudan I 在 铁粉 、 氯化铵 作用下， 以 乙醇 、 水 为溶剂， 反应 0.25h， 以90%的产率得到1-氨基-2-萘酚盐酸盐
  参考文献：
  名称：

  A Simple Reduction Method of Azo-Compounds to Amines Using Fe Powder in the Presence of NH4Cl

  摘要：

  A series of azo-compounds were reduced to related aromatic amines in the presence of Fe powder and ammonium chloride. This one step protocol led to the formation of products in middle to high yields, especially when electron releasing substituted aromatic azo-compounds were reduced.

  DOI：

  10.1007/s00706-007-0633-2
• 作为产物：
  描述：

  1,2-Naphthochinon-1-(phenylhydrazon) 以 二氯甲烷-D2 为溶剂， 生成 sudan I
  参考文献：
  名称：

  1-（芳基偶氮）-2-萘酚的碳 13 NMR 和 X 射线结构测定。固态氮和氧原子之间的分子内质子转移

  摘要：

  涉及 1-(苯基偶氮)-2-萘酚及其 4{prime}-甲氧基、乙氧基和 N,N-二甲氨基衍生物中单质子转移的互变异构反应已用可变温度溶液和高分辨率固体进行了研究。状态{sup 13}C NMR光谱。母体未取代化合物和 4{prime}-N,N-二甲氨基衍生物的晶体结构已经确定。所有这些化合物在 NMR 时间尺度上在溶液和结晶相中的互变异构偶氮和腙形式之间进行快速质子交换。固体材料中的平衡组成类似于在溶液中测量的平衡组成。1-(苯基偶氮)-2-萘酚的晶体为单斜晶系，a = 27.875 (7), b = 6.028 (2), c = 14.928 (5) {埃}, {β} = 103.57 (2){度},空间群是 C2/c，Z = 8，在 1,082 次观察到的反射中，213 K 的结构被细化为 0.0414 的 R 因子。1-((4{prime}-(二甲氨基)苯基)偶氮)-2-萘酚的晶体为单斜晶系，a

  DOI：

  10.1021/ja00197a003

文献信息

• Flash vacuum pyrolysis of azo and nitrosophenols: new routes towards hydroxyarylnitrenes and their reactions
  作者：Yehia A Ibrahim、Nouria A Al-Awadi、Kamini Kual

  DOI：10.1016/s0040-4020(03)00863-9

  日期：2003.7

  Flash vacuum pyrolysis of phenylazonaphthols and nitrosonaphthols at 700°C and 0.02 Torr yielded quinoline, isoquinoline, indene and naphthols (and aniline only from the phenylazo derivatives). Similar FVP of p-nitroso and p-phenylazophenol gave pyridine. Also, FVP of phenanthraquinonemonophenylhydrazone and monooxime gave phenathridine and fluorenone. The formation of the heterocyclic system was assumed

  在700°C和0.02 Torr的条件下，快速真空热解苯基氮杂萘酚和硝基萘酚，生成喹啉，异喹啉，茚和萘酚（仅苯偶氮衍生物衍生出苯胺）。类似的FVP p亚硝基和p -phenylazophenol了吡啶。另外，菲蒽醌单苯基hydr和一肟的FVP得到菲啶和芴酮。假定杂环系统的形成涉及氮和氮杂托酮中间体。
• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• Regiospecific acylations of aromatics and selective reductions of azobenzenes over hydrated zirconia
  作者：M.L Patil、G.K Jnaneshwara、D.P Sabde、M.K Dongare、A Sudalai、V.H Deshpande

  DOI：10.1016/s0040-4039(97)00264-5

  日期：1997.3

  Hydrated zirconia has been found to be an efficient and reusable catalyst for the regiospecific acylations for of arenes and selective reductions of azobenzenes to produce benzo-phenones and hydrazobenzenes respectively.

  已发现水合氧化锆是有效的和可重复使用的催化剂，用于芳烃的区域特异性酰化和选择性还原偶氮苯以分别生产苯并苯甲酮和苯。
• Exploring Flow Procedures for Diazonium Formation
  作者：Te Hu、Ian Baxendale、Marcus Baumann

  DOI：10.3390/molecules21070918

  日期：——

  synthesis of diazonium salts is historically an important transformation extensively utilized in dye manufacture. However the highly reactive nature of the diazonium functionality has additionally led to the development of many new reactions including several carbon-carbon bond forming processes. It is therefore highly desirable to determine optimum conditions for the formation of diazonium compounds

  历史上重氮盐的合成是染料生产中广泛使用的重要转化。然而，重氮官能团的高反应性本质还导致了许多新反应的发展，包括几种碳-碳键形成过程。因此，迫切需要利用最新的加工工具，例如流动化学法，确定重氮化合物形成的最佳条件，以利用增加的安全性和连续制造能力。本文中，我们报告了一系列基于流程的程序，以制备重氮盐以用于随后的原位消费。
• Azo compounds reducing formation and toxicity of amyloid beta aggregation intermediates
  申请人：Mdc Max-Delbrück-Centrum Für Molekulare Medizin Berlin - Buch

  公开号：EP2368558A1

  公开（公告）日：2011-09-28

  The present invention relates to compounds suitable as modulators of protein misfolding and/or protein aggregation. The compounds are particularly suitable as inhibitors of amyloid aggregate formation and/or modulators of amyloid surface properties, and/or as activators of degradation or reduction of amyloid aggregates.

  本发明涉及适用作蛋白质错误折叠和/或蛋白质聚集调节剂的化合物。这些化合物特别适用作淀粉样聚集物形成的抑制剂和/或淀粉样表面特性的调节剂，和/或作为淀粉样聚集物的降解或减少的激活剂。

表征谱图