(+)-(S)-3-aminoheptane | 130232-57-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (+)-(S)-3-aminoheptane
• 英文别名: (S)-3-heptylamine；(S)-1-ethyl-pentylamine；(S)-1-Aethyl-pentylamin；1-Aethyl-pentylamin；(3S)-heptan-3-amine
• CAS: 130232-57-4
• 化学式: C₇H₁₇N
• 分子量: 115.219
• InChiKey: SRMHHEPXZLWKOK-ZETCQYMHSA-N

物化性质

• 沸点：
  144.7±8.0 °C(Predicted)
• 密度：
  0.777±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (+)-(S)-3-aminoheptane 生成 (S)-N-acetyl-3-heptylamine
  参考文献：
  名称：

  Kenyon; Young, Journal of the Chemical Society, 1941, p. 267

  摘要：

  DOI：
• 作为产物：
  描述：

  (S)-2-ethylhexanamide 在 sodium hypobromide 作用下， 生成 (+)-(S)-3-aminoheptane
  参考文献：
  名称：

  Kenyon; Young, Journal of the Chemical Society, 1941, p. 267

  摘要：

  DOI：

文献信息

• Amine dehydrogenases: efficient biocatalysts for the reductive amination of carbonyl compounds
  作者：Tanja Knaus、Wesley Böhmer、Francesco G. Mutti

  DOI：10.1039/c6gc01987k

  日期：——

  Amines constitute the major targets for the production of a plethora of chemical compounds that have applications in the pharmaceutical, agrochemical and bulk chemical industries. However, the asymmetric synthesis of...

  胺是生产大量化合物的主要目标，这些化合物在制药、农业化学和大宗化学工业中有应用。然而，不对称合成...
• [EN] PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ASTHMA, COPD, ALLERGIC RHINITIS, ALLERGIC CONJUNCTIVITIS, ATOPIC DERMATITIS, CANCER, HEPATITIS B, HEPATITIS C, HIV, HPV, BACTERIAL INFECTIONS AND DERMATOSIS<br/>[FR] DÉRIVÉS DE PYRIMIDINE POUR LE TRAITEMENT DE L'ASTHME, DE LA BRONCHO-PNEUMOPATHIE CHRONIQUE OBSTRUCTIVE (COPD), DE LA RHINITE ALLERGIQUE, DE LA CONJONCTIVITE ALLERGIQUE, DE LA DERMATITE ATOPIQUE, DU CANCER, DE L'HÉPATITE B, DE L'HÉPATITE C, DU VIH, DU
  申请人：ASTRAZENECA AB

  公开号：WO2009067081A1

  公开（公告）日：2009-05-28

  The present invention provides compounds of formula (I) wherein R 1, R2, R3 and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

  本发明提供了式（I）中的化合物，其中R1、R2、R3和R4如规范中定义，以及其药用盐，以及它们的制备方法、含有它们的药物组合物以及它们在治疗中的应用。
• PROCESS FOR PRODUCING OPTICALLY ACTIVE AMINO COMPOUNDS
  申请人：KANEKA CORPORATION

  公开号：EP0857790A1

  公开（公告）日：1998-08-12

  A process for producing optically active (R)-amino compounds which comprises treating an aralkyl alkyl ketone compound (the amino receptor) coexisting with a racemic or (R)-amino compound (the amino donor) with an (R)-specific transaminase produced by a microorganism belonging to the genus Arthrobacter and thus effecting stereoselective transamination. This process makes it possible to facilitate the production in a high yield of optically active (R)-amino compounds, etc., having aryl, etc. at the 1-position which have been difficult to synthesize by the conventional techniques.

  一种生产光学活性(R)-氨基化合物的工艺，包括用一种由节肢动物属微生物产生的(R)特异性转氨酶处理与外消旋或(R)-氨基化合物（氨基供体）共存的芳基烷基酮化合物（氨基受体），从而实现立体选择性转氨作用。通过这种工艺，可以高产率地生产出在 1 位上具有芳基等光学活性的（R）-氨基化合物等，而这些化合物用传统技术很难合成。
• Levene; Rothen; Kuna, Journal of Biological Chemistry, 1937, vol. 120, p. 789
  作者：Levene、Rothen、Kuna

  DOI：——

  日期：——
• Efficient enzymatic kinetic resolution of 2-heptylamine with a highly active acyl donor
  作者：Jian-Hua Sun、Rong-Ji Dai、Wei-Wei Meng、Yu-lin Deng

  DOI：10.1016/j.catcom.2010.04.015

  日期：2010.6

  Novozyme435 facilitated kinetic resolution of 2-heptylamine was here presented. Methyl methoxyacetate was used as acyl donor. A survey of influencing factors including hydrogen bonding effect, solvent effect, steric effect, temperature and the amount of acyl donor were investigated in detail. At the optimum conditions, the enantiomeric separation was successfully obtained within 8 h at 20 degrees C. and gave high conversion and optical purity of (R)-2-heptylamine, 48.9% and over 99% respectively. The immobilized lipase B was found to be suitable for the enantiomeric separation of aliphatic amines with good recyclability. (C) 2010 Elsevier B.V. All rights reserved.