DTMR-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: DTMR-2
• 英文别名: Xanthylium, 9-(2,4-dicarboxy-3,6-dichlorophenyl)-3,6-bis(dimethylamino)-；[9-(2,4-dicarboxy-3,6-dichlorophenyl)-6-(dimethylamino)xanthen-3-ylidene]-dimethylazanium
• 化学式: C₂₅H₂₁Cl₂N₂O₅
• 分子量: 500.358
• InChiKey: KWFRWLVSVLQCPR-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  90.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-羟基丁二酰亚胺 、 DTMR-2 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 DTMR-2-NHS
  参考文献：
  名称：

  Method for detecting oligonucleotides using energy transfer dyes with long stoke shift

  摘要：

  提供了一种新的连接剂，用于将给体染料与受体染料连接在能量转移荧光染料中。这些连接剂促进了给体染料和受体染料之间的能量高效转移。其中一种连接剂用于将给体染料与受体染料连接在能量转移荧光染料中，具有一般结构R21Z1C（O）R22R26，其中R21是附加在给体染料上的C1-5烷基，C（O）是一个羰基，Z1是NH、硫或氧，R22是一个取代基，包括烯烃、二烯、炔烃、至少有一个不饱和键的五元和六元环或附加在羰基碳上的融合环结构，而R28包括一个功能基团，将连接剂连接到受体染料上。

  公开号：

  US06335440B1
• 作为产物：
  描述：

  、 3-羟基-N,N-二甲基苯胺 在 硫酸 、 丙酸 作用下， 反应 18.0h， 以35 mg的产率得到DTMR-2
  参考文献：
  名称：

  二氯罗丹明染料的合成方法及其应用

  摘要：

  本发明公开了二氯罗丹明染料的合成方法及其应用，以及制备式(I)和式(II)所示化合物的方法。该方法包括：将式(I‑a)所示化合物与式(I‑b)所示化合物进行傅克酰基化反应，以便获得式(I)和/或式(II)所示化合物。该方法可以实现原子经济性高，操作简便，低成本，易于大规模生产的目标，也为后续的反应提供了高纯度的原料。

  公开号：

  CN111763190A

文献信息

• 化合物、其制备方法与用途
  申请人：湖北华大基因研究院

  公开号：CN114621306A

  公开（公告）日：2022-06-14

  本发明提出了化合物、其制备方法与用途。所述化合物具有式(Ⅰ)所示结构，该化合物作为Linker，通过两步反应即可完成拼接，所得拼接化合物具有很好的化学稳定性和光学性质，用于基因测序，该合成路线快速、直接、高效，且原子经济性高、操作简便、低成本，易于大规模生产，具有广泛的应用前景。
• METHODS OF ANALYZING POLYNUCLEOTIDES EMPLOYING ENERGY TRANSFER DYES
  申请人：Lee G. Linda

  公开号：US20070154925A1

  公开（公告）日：2007-07-05

  Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R 21 Z 1 C(O)R 22 R 28 where R 21 is a C 1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z 1 is either NH, sulfur or oxygen, R 22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R 28 includes a functional group which attaches the linker to the acceptor dye.
• ENERGY TRANSFER DYES WITH ENHANCED FLUORESCENCE
  申请人：Lee G. Linda

  公开号：US20070154927A1

  公开（公告）日：2007-07-05

  Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R 21 Z 1 C(O)R 22 R 28 where R 21 is a C 1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z 1 is either NH, sulfur or oxygen, R 22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R 28 includes a functional group which attaches the linker to the acceptor dye.
• OLIGONUCLEOTIDES AND ANALOGS LABELED WITH ENERGY TRANSFER DYES
  申请人：Lee G. Linda

  公开号：US20070161027A1

  公开（公告）日：2007-07-12

  Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R 21 Z 1 C(O)R 22 R 28 where R 21 is a C 1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z 1 is either NH, sulfur or oxygen, R 22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R 28 includes a functional group which attaches the linker to the acceptor dye.
• REGENTS LABELED WITH ENERGY TRANSFER DYES
  申请人：Lee G. Linda

  公开号：US20070161026A1

  公开（公告）日：2007-07-12

  Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R 21 Z 1 C(O)R 22 R 28 where R 21 is a C 1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z 1 is either NH, sulfur or oxygen, R 22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R 28 includes a functional group which attaches the linker to the acceptor dye.