Cyclopentancarboximidsaeure-methylester-hydrochlorid | 109152-86-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 甲亚胺酸及其衍生物
• 英文名称: Cyclopentancarboximidsaeure-methylester-hydrochlorid
• 英文别名: cyclopentanecarboximidic acid methyl ester hydrochloride；cyclopentanecarbonimidic acid methyl ester; hydrochloride；Cyclopentancarbimidsaeure-methylester; Hydrochlorid；Cyclopentanecarboximidic acid, methyl ester, hydrochloride；methyl cyclopentanecarboximidate;hydrochloride
• CAS: 109152-86-5
• 化学式: C₇H₁₃NO*ClH
• 分子量: 163.647
• InChiKey: BTEYJKYYCFVKSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.22
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  33.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Cyclopentancarboximidsaeure-methylester-hydrochlorid 在 N,N-二甲基甲酰胺 作用下， 生成 环戊烷羧酰胺
  参考文献：
  名称：

  Ketene Acetals. XXXIV. Tetra- and Pentamethylene Ketene Acetals

  摘要：

  DOI：

  10.1021/ja01622a040
• 作为产物：
  描述：

  1-羟基环戊烷甲腈 在 盐酸 、 Pd/SrCO₃ 、 乙醚 、 乙酸酐 、 乙酰氯 作用下， 生成 Cyclopentancarboximidsaeure-methylester-hydrochlorid
  参考文献：
  名称：

  Ketene Acetals. XXXIV. Tetra- and Pentamethylene Ketene Acetals

  摘要：

  DOI：

  10.1021/ja01622a040

文献信息

• [EN] PARTICLES, COMPOSITIONS, AND METHODS FOR OPHTHALMIC AND/OR OTHER APPLICATIONS<br/>[FR] PARTICULES, COMPOSITIONS ET PROCÉDÉS POUR APPLICATIONS OPHTALMIQUES ET/OU AUTRES APPLICATIONS
  申请人：KALA PHARMACEUTICALS INC

  公开号：WO2019055028A1

  公开（公告）日：2019-03-21

  This disclosure relates to particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications.

  本公开涉及有助于粘液中颗粒传输的颗粒、组合物和方法。这些颗粒、组合物和方法在某些情况下可用于眼科和/或其他应用。
• Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor
  作者：Robert J. Young、Wendy Alderton、Anthony D.R. Angell、Paul J. Beswick、David Brown、C. Lynn Chambers、Miriam C. Crowe、John Dawson、Christopher C.F. Hamlett、Simon T. Hodgson、Savvas Kleanthous、Richard G. Knowles、Linda J. Russell、Richard Stocker、James M. Woolven

  DOI：10.1016/j.bmcl.2011.03.038

  日期：2011.5

  Heteroalicyclic carboxamidines were synthesised and evaluated as inhibitors of nitric oxide synthases. (2R)-2-Pyrrolidinecarboxamidine, in particular, was shown to be a highly potent in vitro (IC(50) = 0.12 mu M) and selective iNOS inhibitor (> 100-fold vs both eNOS and nNOS), with probable binding to the key anchoring glutamate residue and co-ordination to the haem iron. (C) 2011 Elsevier Ltd. All rights reserved.
• Gruseck, Ursula; Heuschmann, Manfred, Chemische Berichte, 1987, vol. 120, p. 2053 - 2064
  作者：Gruseck, Ursula、Heuschmann, Manfred

  DOI：——

  日期：——
• Improved Pinner Reaction with CPME as a Solvent
  作者：Kiyoshi Watanabe、Naoto Kogoshi、Hideaki Miki、Yasuhiro Torisawa

  DOI：10.1080/00397910802632548

  日期：2009.5.7

  The classical Pinner reaction has been improved by the utilization of 4N-HCl solution in cyclopentyl methyl ether (CPME) as a solvent, wherein direct isolation of the product was possible by a simple filtration.
• McElvain; Starn, Journal of the American Chemical Society, 1955, vol. 77, p. 571,4574
  作者：McElvain、Starn

  DOI：——

  日期：——