2,4(1H,3H)-蝶啶二酮,6,7-二苯基- | 14892-98-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 中文名称: 2,4(1H,3H)-蝶啶二酮,6,7-二苯基-
• 英文名称: 6,7-diphenylpteridine-2,4(1H,3H)-dione
• 英文别名: 6,7-diphenyl-1H-pteridine-2,4-dione；6,7-Diphenyl-1H-pteridin-2,4-dion；6,7-diphenyl-1H-pteridine-2,4-dione
• CAS: 14892-98-9
• 化学式: C₁₈H₁₂N₄O₂
• 分子量: 316.319
• InChiKey: GOULKEOXQNZISP-UHFFFAOYSA-N

物化性质

• 熔点：
  310-315 °C(Solv: acetic acid (64-19-7))
• 密度：
  1.42±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  84
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,4(1H,3H)-蝶啶二酮,6,7-二苯基- 在 五氯化磷 、 三氯氧磷 作用下， 生成 2,4-二氯-6,7-二苯基-蝶啶
  参考文献：
  名称：

  Pteridines. VI. Replacement Reactions of Amino, Hydroxyl and Mercapto Groups in the Pteridine Series^1,2

  摘要：

  DOI：

  10.1021/ja01153a102
• 作为产物：
  描述：

  2,3-二氢-6,7-二苯基-2-硫代-4(1H)-蝶啶酮 在 sodium hydroxide 、 双氧水 作用下， 生成 2,4(1H,3H)-蝶啶二酮,6,7-二苯基-
  参考文献：
  名称：

  Polonovski et al., Bulletin de la Societe Chimique de France, 1945, vol. <5> 12, p. 78,82

  摘要：

  DOI：

文献信息

• Vasculostatic agents and methods of use thereof
  申请人：Wrasidlo Wolfgang

  公开号：US20050282814A1

  公开（公告）日：2005-12-22

  Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as retinopathies or macular degeneration or other vitreoretinal diseases, inflammatory diseases, vascular leakage syndrome, edema, transplant rejection, adult/acute respiratory distress syndrome (ARDS), and the like.

  提供了用于治疗与血管稳态受损相关的疾病的组合物和方法。发明的方法和组合物可用于治疗各种疾病，包括中风、心肌梗死、癌症、缺血/再灌注损伤、类风湿性关节炎等自身免疫疾病、眼部疾病如视网膜病变或黄斑变性或其他玻璃体视网膜疾病、炎症性疾病、血管渗漏综合征、水肿、移植排斥反应、成人/急性呼吸窘迫综合征（ARDS）等。
• Novel Riboflavin-Inspired Conjugated Bio-Organic Semiconductors
  作者：Jan Richtar、Patricie Heinrichova、Dogukan Apaydin、Veronika Schmiedova、Cigdem Yumusak、Alexander Kovalenko、Martin Weiter、Niyazi Sariciftci、Jozef Krajcovic

  DOI：10.3390/molecules23092271

  日期：——

  Flavins are known to be extremely versatile, thus enabling routes to innumerable modifications in order to obtain desired properties. Thus, in the present paper, the group of bio-inspired conjugated materials based on the alloxazine core is synthetized using two efficient novel synthetic approaches providing relatively high reaction yields. The comprehensive characterization of the materials, in order to evaluate the properties and application potential, has shown that the modification of the initial alloxazine core with aromatic substituents allows fine tuning of the optical bandgap, position of electronic orbitals, absorption and emission properties. Interestingly, the compounds possess multichromophoric behavior, which is assumed to be the results of an intramolecular proton transfer.

  黄素被认为是非常多功能的，因此可以通过多种修改途径来获得所需的性质。因此，在本文中，基于阿洛克赛因核心的生物启发共轭材料群体使用两种高效的新型合成方法合成，提供了相对较高的反应产率。对材料的全面表征，以评估其性质和应用潜力，表明将初始的阿洛克赛因核心与芳香族取代基进行改性可以微调光学带隙、电子轨道位置、吸收和发射性质。有趣的是，这些化合物具有多色色团行为，这被认为是分子内质子转移的结果。
• Nucleotides. Part LIV. Synthesis of condensedN1-(2?-deoxy-?-D-ribofuranosyl)lumazines, New fluorescent building blocks in oligonucleotide synthesis
  作者：Angelika Rosler、Wolfgang Pfleiderer

  DOI：10.1002/hlca.19970800611

  日期：1997.9.22

  3′-(2-cyanoethyI diisopropylphosphoramidites) 34–39 which function as monomeric building block in oligonucleotide syntheses as well as into the 3′-(hydrogen succinates) 40–45 which can be used for coupling with the solid-support material. A series of lumazine-modified oligonucleotides were synthesized and the influence of the new nucleobases on the stability of duplex formation studied by measuring the Tm values

  各种缩合areno [克] lumazine衍生物2，3，和5 - 7合成作为糖基化反应的新的荧光苷元与2-脱氧-3，5-二- Ö - （p甲苯甲酰）-α/β-D-在Hilbert - Johnson - Birkofer反应中，赤型-五氟呋喃糖酰氯（10）形成相应的N 1-（2'-deoxyribonucleosides）15 – 21。的βd端基异构体15，17，19，和21被解封为24 – 27，并与N 1-（2'-脱氧-β-D-呋喃呋喃糖基）lumazine（22）及其6，6，7-二苯基衍生物23一起在5'-位被二甲氧基三苯甲基化为28-33。然后将这些中间体转化成3' - （2- cyanoethyI diisopropylphosphoramidites）34 - 39，其功能如在寡核苷酸合成以及进3单体结构单元' - （氢琥珀酸酯）40 - 45可用于与固相支持材料偶联。合成
• Kinase inhibitors and methods of use thereof
  申请人：Doukas John

  公开号：US20070259876A1

  公开（公告）日：2007-11-08

  Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as uveitis, retinopathies or macular degeneration, macular edema or other vitreoretinal diseases, inflammatory diseases such as autoimmune diseases, vascular leakage syndrome, edema, or diseases involving leukocyte activation, transplant rejection, respiratory diseases such as asthma, adult or acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease, and the like.

  提供了用于治疗与血管稳态受损相关的疾病的组合物和方法。发明方法和组合物可用于治疗多种疾病，包括中风、心肌梗死、癌症、缺血/再灌注损伤、类风湿关节炎等自身免疫疾病、眼部疾病如葡萄膜炎、视网膜病变或黄斑变性、黄斑水肿或其他玻璃体视网膜疾病、自身免疫疾病、血管渗漏综合征、水肿或涉及白细胞活化的疾病、移植排斥反应、呼吸道疾病如哮喘、成人或急性呼吸窘迫综合征（ARDS）、慢性阻塞性肺疾病等。
• VASCULOSTATIC AGENTS AND METHODS OF USE THEREOF
  申请人：Wrasidlo Wolfgang

  公开号：US20100278811A1

  公开（公告）日：2010-11-04

  Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as retinopathies or macular degeneration or other vitreoretinal diseases, inflammatory diseases, vascular leakage syndrome, edema, transplant rejection, adult/acute respiratory distress syndrome (ARDS), and the like.

  本发明提供了用于治疗与血管稳态受损相关的疾病的组合物和方法。本发明的方法和组合物可用于治疗各种疾病，例如中风、心肌梗塞、癌症、缺血/再灌注损伤、自身免疫疾病，如类风湿性关节炎、眼部疾病，如视网膜病变或黄斑变性或其他玻璃体视网膜疾病、炎症性疾病、血管渗漏综合症、水肿、移植排斥、成人/急性呼吸窘迫综合症（ARDS）等。