丙-1-烯-1-胺 | 43691-07-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 丙-1-烯-1-胺
• 英文名称: ethylidenemethanamine
• 英文别名: 1-propaneenylamine；prop-1-en-1-amine；1-aminoprop-1-en；propaneN-1-amine；propaneenylamine；1-propenylamine；N-propenylamine；propene-1-amine；1-aminopropene；aminopropylene；propaneenamine；propen-1-amine；1-propenamine；N-propenamine；propenylamine；aminopropene；propeneamine；propenamine
• CAS: 43691-07-2
• 化学式: C₃H₇N
• 分子量: 57.0953
• InChiKey: AMLFJZRZIOZGPW-UHFFFAOYSA-N

物化性质

• 沸点：
  54.6±9.0 °C(Predicted)
• 密度：
  0.757±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  丙-1-烯-1-胺 在 三(三苯基膦)羰基氢化铑 作用下， 以 氘代苯 为溶剂， 生成 1-丙亚胺
  参考文献：
  名称：

  亚稳定的烯胺：通过烯丙基胺底物的催化异构化反应合成简单的烯胺。

  摘要：

  DOI：

  10.1021/ja011609i
• 作为产物：
  描述：

  丙烯胺 在 三(三苯基膦)羰基氢化铑 作用下， 以 氘代苯 为溶剂， 生成 丙-1-烯-1-胺
  参考文献：
  名称：

  亚稳定的烯胺：通过烯丙基胺底物的催化异构化反应合成简单的烯胺。

  摘要：

  DOI：

  10.1021/ja011609i

文献信息

• Lamellar Ni/Al-SBA-15 fibers: preparation, characterization, and applications as highly efficient catalysts for amine and imine syntheses
  作者：Ren Ren、Jiantai Ma

  DOI：10.1039/c5ra14382a

  日期：——

  A novel lamellar Ni/Al-SBA-15 fiber catalyst was prepared and successfully utilized in one-pot syntheses of amines and imines.

  一种新型的层状Ni/Al-SBA-15纤维催化剂已经制备成功，并成功地用于胺和亚胺的一锅法合成。
• Developing highly active small molecule ice recrystallization inhibitors based upon C-linked antifreeze glycoprotein analogues
  作者：John F. Trant、Robyn A. Biggs、Chantelle J. Capicciotti、Robert N. Ben

  DOI：10.1039/c3ra43835j

  日期：——

  Ice recrystallization during cryopreservation results in a significant amount of cellular damage making compounds that exhibit ice recrystallization inhibition (IRI) activity desirable as a novel class of cryoprotectants. Herein, we report a systematic structure–function study on a previously identified IRI active C-linked antifreeze glycoprotein (C-AFGP) analogue (1). These studies indicate that while C-AFGPs containing three tripeptide repeats exhibit weak IRI activity 5.5 μM, a minimum number of four tripeptide repeats is required for potent IRI activity at this concentration. In addition, the galactosyl–ornithine building block 5 exhibited only moderate activity at 22 mM, but IRI activity was significantly increased upon addition of two glycine units to the C-terminal end of the amino acid bearing the C-linked galactopyranose residue. Finally, we report that conjugation of long alkyl chains (octyl, nonyl and decyl) to the C-linked galactosyl moiety of 1 can furnish IRI active small molecules. The “ideal” hydrocarbon chain length was 10 carbons for potent activity in this series of compounds. Longer hydrocarbon chain lengths dramatically decreased solubilities. The results of this study emphasize the importance of hydrophobic moieties for IRI activity and while consistent with previously reported small molecule carbohydrate-based and lysine-based ice recrystallization inhibitors, is the first example where a large IRI active glycoconjugate has been successfully truncated to small molecule IRI active components.

  冰晶再结晶在冷冻保存过程中会造成显著的细胞损伤，使得展现冰晶再结晶抑制（IRI）活性的化合物成为一种新型冷冻保护剂的理想选择。在此，我们报告了一项对先前鉴定的C-连接抗冻糖蛋白（C-AFGP）类似物（1）的系统结构-功能研究。这些研究表明，虽然含有三个肽链重复单元的C-AFGP展现出弱的IRI活性（5.5 μM），但在此浓度下，要求至少四个肽链重复单元以展现强效的IRI活性。此外，半乳糖苷-鸟氨酸构建块5在22 mM时仅表现出中等活性，但当将两个甘氨酸单元添加到带有C-连接半乳糖吡喃糖基残基的氨基酸的C末端时，IRI活性显著增加。最后，我们报告将长烷基链（辛基、壬基和癸基）连接到1的C-连接半乳糖基部分可以生成具有IRI活性的低分子化合物。在这一系列化合物中，"理想"的烃链长度为10个碳，以展现强效活性。更长的烃链长度显著降低了溶解度。本研究的结果强调了疏水基团对IRI活性的关键重要性，虽然与先前报告的基于小分子碳水化合物和赖氨酸的冰晶再结晶抑制剂一致，但这是首次成功将大型IRI活性糖缀合物截短至小分子IRI活性成分的例子。
• Synthesis and antibacterial activity of new 4″-O-carbamates of 11,12-cyclic carbonate erythromycin A 6,9-imino ether
  作者：Ling Zhang、Bo Jiao、Xiangrui Yang、Lin Liu、Shutao Ma

  DOI：10.1038/ja.2010.166

  日期：2011.3

  A series of new 4″-O-carbamates of 11,12-cyclic carbonate erythromycin A 6,9-imino ether were synthesized and evaluated for their in vitro antibacterial activity. All the desired compounds demonstrated favorable activity (0.03 μg ml–1) against erythromycin-susceptible Streptococcus pneumoniae comparable to the references, exhibiting 133-fold higher activity than precursor 2 or 3. Similarly, all of the analogs exhibited improved activity against the erythromycin-resistant S. pneumoniae encoded by the erm gene and the erm and mef genes, showing 4–32-fold more effectiveness than erythromycin A.

  合成了一系列新的4″-O-氨基甲酸酯的11,12-环碳酸酯红霉素A 6,9-亚氨基醚，并评估了它们的体外抗菌活性。所有目标化合物对红霉素敏感的肺炎链球菌展现出良好的活性（0.03â€ μgâ€ ml–1），与参考物相当，活性比前体2或3高出133倍。同样，所有类比化合物对携带erm基因以及erm和mef基因的红霉素耐药肺炎链球菌表现出了改进的活性，比红霉素A有效性提高了4–32倍。
• Directed Rh ^I ‐Catalyzed Asymmetric Hydroboration of Prochiral 1‐Arylcycloprop‐2‐Ene‐1‐Carboxylic Acid Derivatives
  作者：Andrew Edwards、Marina Rubina、Michael Rubin

  DOI：10.1002/chem.201704443

  日期：2018.1.26

  A full account on rhodium‐catalyzed asymmetric, directed hydroboration of functionalized prochiral cyclopropenes affording enantiomerically enriched cyclopropylboronates is reported. The scope and limitations of two alternate directing groups, ester and carboxamide, are evaluated. It was found that hydroboration of esters appeared to be more sensitive to substitution in the aromatic ring of the substrates

  完整报道了铑催化的功能化前手性环丙烯的不对称，定向氢硼化，从而提供对映异构体富集的环丙基硼酸酯。评价了两个替代的导向基团，酯和羧酰胺的范围和局限性。发现酯的硼氢化似乎对底物的芳环中的取代更敏感。特别是，邻卤素对非对映异构体和对映体选择性有害，这可能是由于与铑的额外配位。相反，更多的路易斯碱酰胺导向基团允许与过渡金属更强的螯合，从而导致在更大范围的底物中，硼氢化反应中始终具有很高的非对映选择性和对映选择性。
• [EN] 1,4 DIHYDROPYRIDINE DERIVATIVES AND THEIR USES<br/>[FR] DÉRIVÉS DE LA 1,4-DIHYDROPYRIDINE ET LEURS UTILISATIONS
  申请人：UNIV LILLE II DROIT & SANTE

  公开号：WO2010133973A1

  公开（公告）日：2010-11-25

  The present invention relates to 1,4-dihydropyridine derivatives of the formula (I) and their uses in the treatment and/or prevention of diseases and disorders directly or indirectly associated with the modification (increase or decrease) of the activity of the cannabinoid receptor 2 (CB2).

  本发明涉及式(I)的1,4-二氢吡啶衍生物及其在治疗和/或预防与大麻素受体2（CB2）的活性修改（增加或减少）直接或间接相关的疾病和紊乱中的用途。