2-{(E)-2-[5-(2,5-Dichloro-phenyl)-furan-2-yl]-vinyl}-benzooxazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: 2-{(E)-2-[5-(2,5-Dichloro-phenyl)-furan-2-yl]-vinyl}-benzooxazole
• 英文别名: 2-[(E)-2-[5-(2,5-dichlorophenyl)furan-2-yl]ethenyl]-1,3-benzoxazole
• 化学式: C₁₉H₁₁Cl₂NO₂
• 分子量: 356.208
• InChiKey: HADCCLJVHKSBPQ-JXMROGBWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-(2,5-二氯苯基)糖醛 在 氢氧化钾 、 sodium acetate 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 生成 2-{(E)-2-[5-(2,5-Dichloro-phenyl)-furan-2-yl]-vinyl}-benzooxazole
  参考文献：
  名称：

  5-Aryl-2-furaldehydes in the Synthesis of 2-Substituted 1,3-Benzazoles

  摘要：

  2-[2-(5-Aryl-2-furyl)ethenyl]-1,3-benzazoles were synthesized by reaction of 5-aryl-2-furaldehydes with 2-methylbenzoxazole, 2-methylbenzothiazole, 2-methylbenzimidazole, and 2-cyanomethylbenzimidazole. The corresponding benzazoles were also obtained by reaction of N-(5-arylfurfurylidene)anilines with 2-methylbenzoxazoles and of 3-(5-aryl-2-furyl)-2-cyanopropenoyl chlorides with o-phenylenediamine. The acylation of o-aminophenol with 3-(5-aryl-2-furyl)-2-cyanopropenoyI chlorides occurs at the amino group without subsequent oxazole ring closure.

  DOI：

  10.1023/b:rujo.0000010217.17000.e6

文献信息

• [EN] SELECTIVE LIGANDS FOR TAU AGGREGATES<br/>[FR] LIGANDS SÉLECTIFS POUR AGRÉGATS TAU
  申请人：KARIN & STEN MORTSTEDT CBD SOLUTIONS AB

  公开号：WO2019025595A1

  公开（公告）日：2019-02-07

  The invention provides compounds of formula (I) and compositions comprising compounds of formula (I). The invention further provides uses of the compounds of formula (I) and compositions comprising compounds of formula (I), including the use of such compounds for the detection of tau deposits, and the use of such compounds and compositions as diagnostic agents in the diagnosis or monitoring of the progression of a disease or disorder such as Alzheimer's disease or corticobasal degeneration, or for the prevention or treatment of a disease or disorder such as Alzheimer's disease or corticobasal degeneration.

  该发明提供了公式（I）的化合物和包含公式（I）化合物的组合物。该发明还提供了公式（I）的化合物的用途和包含公式（I）化合物的组合物的用途，包括利用这些化合物检测tau沉积物，以及将这些化合物和组合物用作诊断剂，用于诊断或监测疾病或疾病进展的进展，例如阿尔茨海默病或皮质基底节变性，或用于预防或治疗疾病或疾病，例如阿尔茨海默病或皮质基底节变性。
• SELECTIVE LIGANDS FOR TAU AGGREGATES
  申请人：KARIN & STEN MORTSTEDT CBD SOLUTIONS AB

  公开号：US20200369659A1

  公开（公告）日：2020-11-26

  The invention provides compounds of formula (I) and compositions comprising compounds of formula (I). The invention further provides uses of the compounds of formula (I) and compositions comprising compounds of formula (I), including the use of such compounds for the detection of tau deposits, and the use of such compounds and compositions as diagnostic agents in the diagnosis or monitoring of the progression of a disease or disorder such as Alzheimer's disease or corticobasal degeneration, or for the prevention or treatment of a disease or disorder such as Alzheimer's disease or corticobasal degeneration.
• 5-Aryl-2-furaldehydes in the Synthesis of 2-Substituted 1,3-Benzazoles
  作者：N. I. Ganushchak、A. I. Lesyuk、I. S. Fedorovich、N. D. Obushak、V. N. Andrushko

  DOI：10.1023/b:rujo.0000010217.17000.e6

  日期：2003.9

  2-[2-(5-Aryl-2-furyl)ethenyl]-1,3-benzazoles were synthesized by reaction of 5-aryl-2-furaldehydes with 2-methylbenzoxazole, 2-methylbenzothiazole, 2-methylbenzimidazole, and 2-cyanomethylbenzimidazole. The corresponding benzazoles were also obtained by reaction of N-(5-arylfurfurylidene)anilines with 2-methylbenzoxazoles and of 3-(5-aryl-2-furyl)-2-cyanopropenoyl chlorides with o-phenylenediamine. The acylation of o-aminophenol with 3-(5-aryl-2-furyl)-2-cyanopropenoyI chlorides occurs at the amino group without subsequent oxazole ring closure.