4-dimethylamino-N-(2-maleimido)ethyl-1,8-naphthalimide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 4-dimethylamino-N-(2-maleimido)ethyl-1,8-naphthalimide
• 英文别名: 6-(Dimethylamino)-2-[2-(2,5-dioxopyrrol-1-yl)ethyl]benzo[de]isoquinoline-1,3-dione
• 化学式: C₂₀H₁₇N₃O₄
• 分子量: 363.373
• InChiKey: CNSIJQNYHJNFFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  78
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-溴-1,8-萘二甲酸酐 在 三乙胺 、 三氟乙酸 作用下， 以 乙醇 、 二氯甲烷 、 乙二醇甲醚 为溶剂， 反应 21.5h， 生成 4-dimethylamino-N-(2-maleimido)ethyl-1,8-naphthalimide
  参考文献：
  名称：

  含氮杂环丁烷的杂环杂环可增强荧光团的性能。

  摘要：

  荧光染料广泛用于各种荧光成像技术中。但是，许多现有的修饰策略无法平衡荧光团的性能（例如亮度，光稳定性，水溶性和渗透性）。本文中，我们报告了通过将含氮杂环丁烷的杂螺环引入常用的荧光支架中来增强供体-受体型荧光团性能的一般策略。事实证明，这种策略是开发高质量荧光团的一般方法。

  DOI：

  10.1021/acs.orglett.0c01414

文献信息

• Novel side-chain alternative copolymer combined FRET and DRET with large pseudo-Stokes shift and polarity-sensitive fluorescence behavior
  作者：Yan Yu、Bohao Yang、Yongjie Yuan、Hailiang Zhang

  DOI：10.1039/c9tc03421h

  日期：——

  both as emissive donor in the aggregation state and dark donor in solution, this copolymer exhibited fluorescence resonance energy transfer (FRET) and dark resonance energy transfer (DRET) processes from TPE to NI, so it remained emissive whether in solution or aggregation state, and the fluorescence intensity of NI was increased obviously compared to when it was excited directly without energy transfer

  设计并合成了一种新颖的替代共聚物，该共聚物将四苯乙烯（TPE）和萘二甲酰亚胺（NI）掺入苯乙烯和马来酸酐作为侧链。归因于TPE单元既在聚集态中充当发射供体，又在溶液中充当深色供体，该共聚物表现出从TPE到NI的荧光共振能量转移（FRET）和暗共振能量转移（DRET）过程，因此无论是否在与在没有能量转移的情况下直接激发相比，NI的荧光强度明显增加。此外，该替代共聚物在聚集状态下显示出令人印象深刻的伪斯托克斯位移，其位移高达215 nm，大于所有其他已报道体系的FRET和DRET组合结果。最后，
• Environmentally sensitive fluorophores
  申请人：Imperiali Barbara

  公开号：US20080206885A1

  公开（公告）日：2008-08-28

  The present invention provides novel fluorophore compounds.
• ENVIRONMENTALLY SENSITIVE FLUOROPHORES
  申请人：Imperiali Barbara

  公开号：US20100168428A1

  公开（公告）日：2010-07-01

  The present invention generally relates to environment-sensitive fluorophores, including environment-sensitive fluorophores for reporting protein/protein and peptide/protein interactions. In one aspect, the present invention is directed to compounds and salts thereof, compositions and methods useful in determining biological interactions. In some cases, the compounds of the present invention are environment-sensitive fluorophores that have spectroscopic behavior that may depend on factors such as the physicochemical properties of the surrounding environment. The compounds of the present invention can be used, in certain embodiments, to monitor ions, small molecules, and biological processes such as protein folding, protein-protein interactions and phosphorylation events.
• US8440835B2
  申请人：——

  公开号：US8440835B2

  公开（公告）日：2013-05-14
• [EN] ENVIRONMENTALLY SENSITIVE FLUOROPHORES<br/>[FR] FLUOROPHORES SENSIBLES À L'ENVIRONNEMENT
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2008106104A2

  公开（公告）日：2008-09-04

  [EN] The present invention generally relates to environment-sensitive fluorophores, including environment-sensitive fluorophores for reporting protein/protein and peptide/protein interactions. In one aspect, the present invention is directed to compounds and salts thereof, compositions and methods useful in determining biological interactions. In some cases, the compounds of the present invention are environment- sensitive fluorophores that have spectroscopic behavior that may depend on factors such as the physicochemical properties of the surrounding environment. The compounds of the present invention can be used, in certain embodiments, to monitor ions, small molecules, and biological processes such as protein folding, protein-protein interactions and phosphorylation events.
  [FR] L'invention concerne des fluorophores sensibles à l'environnement, y compris des fluorophores sensibles à l'environnement pour signaler des interactions protéine/protéine et peptide/protéine. Selon un aspect, la présente invention concerne des compositions et des sels de ceux-ci, des compositions et des procédés utiles pour déterminer des interactions biologiques. Dans certains cas, les composés de la présente invention sont des fluorophores sensibles à l'environnement qui ont un comportement spectroscopique qui peut dépendre de facteurs tels que les propriétés physico-chimiques de l'environnement environnant. Les composés de la présente invention peuvent être utilisés, selon certains modes de réalisation, pour surveiller des ions, de petites molécules, et des processus biologiques tels qu'un repliement de protéines, des interactions protéine/protéine et des événements de phosphorylation.