2-cyclopropyl-2-oxazoline | 30192-93-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: 2-cyclopropyl-2-oxazoline
• 英文别名: 2-Cyclopropyl-Δ²-oxazolin；2-cyclopropyl-4,5-dihydro-oxazole；2-Cyclo-propyl-2-oxazoline；2-cyclopropyl-4,5-dihydro-1,3-oxazole
• CAS: 30192-93-9
• 化学式: C₆H₉NO
• 分子量: 111.144
• InChiKey: OBIHXJLKWHVCEA-UHFFFAOYSA-N

物化性质

• 沸点：
  154.3±9.0 °C(Predicted)
• 密度：
  1.34±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-cyclopropyl-2-oxazoline 在 sodium tetrahydroborate 作用下， 以 二氯甲烷 为溶剂， 反应 2.5h， 生成
  参考文献：
  名称：

  一种环丙基甲醛的合成新方法

  摘要：

  本发明涉及一种环丙基甲醛的合成新方法，该方法以环丙基甲酰氯为起始原料，首先与乙醇胺反应制备化合物b，再经闭环制备化合物c,化合物c与酰卤或卤代烃反应制备化合物d，化合物d由NaBH4还原制备化合物e，然后水解制备目标产物环丙基甲醛。本发明所述合成新方法，原料易得，总收率高，条件温和可控，具有良好的工业化可行性。

  公开号：

  CN111574343A
• 作为产物：
  描述：

  1-cyclopropanecarbonyl-aziridine 以 1,4-二氧六环 为溶剂， 生成 2-cyclopropyl-2-oxazoline
  参考文献：
  名称：

  Dehmlow,E.V.; Westendorf,H.J., Zeitschrift fur Naturforschung. Teil B: Chemie, Biochemie, Biophysik, Biologie, 1970, vol. 25, p. 1191

  摘要：

  DOI：

文献信息

• Ag ^I ‐Catalyzed Reaction of Enol Diazoacetates and Imino Ethers: Synthesis of Highly Functionalized Pyrroles
  作者：Kuiyong Dong、Ahmad Humeidi、Wendell Griffith、Hadi Arman、Xinfang Xu、Michael P. Doyle

  DOI：10.1002/anie.202101641

  日期：2021.6.7

  AgI-catalyzed efficient method for the coupling of imino ethers and enol diazoacetates through a [3+2]-cycloaddition/C−O bond cleavage/[1,5]-proton transfer cascade process is reported. The general class of imino ethers that includes oxazolines, benzoxazoles and benzimidates are applicable substrates for these reactions that provide direct access to fully substituted pyrroles with uniformly high chemo- and

  报道了一种前所未有的 Ag I催化有效方法，用于通过 [3+2]-环加成/C-O 键裂解/[1,5]-质子转移级联过程偶联亚氨基醚和烯醇重氮乙酸酯。包括恶唑啉、苯并恶唑和苯甲亚胺酯在内的一般亚氨基醚类是这些反应的适用底物，可直接获得具有均匀高化学和区域选择性的完全取代的吡咯。吡咯 2-、5- 和 N-位取代的高度可变性表征了这种方法，该方法也提供了通过对所得 N-官能吡咯的轻松修饰来进一步实现吡咯多样化的切入点。
• DECIVE FOR FABRICATING A PERFUSABLE THREE-DIMENSIONAL TISSUE CONSTRUCT
  申请人：Julius-Maximilians-Universität Würzburg

  公开号：EP4071234A1

  公开（公告）日：2022-10-12

  The invention relates to a device for fabricating a perfusable three-dimensional tissue construct as well as to its manufacture and use. The device comprises a chamber in which the tissue construct may be cultivated, the chamber comprising an inlet and an outlet for perfusing the tissue construct, and a sacrificial scaffold fixed in the chamber. The sacrificial scaffold comprises a thermo-responsive polymer, the thermo-responsive polymer being not dissolvable in water at human body temperature and becoming dissolvable in water at a temperature below 30°C, preferably below 25°C. The sacrificial scaffold comprises at least one filament extending from the inlet to the outlet such that dissolution of the sacrificial scaffold provides for a liquid channel from the inlet to the outlet. The sacrificial scaffold seals the inlet and/or the outlet such that dissolution of the sacrificial scaffold after receiving a cultivation matrix in the chamber provides for a liquid channel from the inlet to the outlet through the cultivation matrix.

  本发明涉及一种用于制造可灌注三维组织构建体的装置及其制造和使用。该装置包括一个可培养组织构建体的腔室，腔室包括一个用于灌注组织构建体的入口和出口，以及一个固定在腔室内的牺牲支架。牺牲支架包括热响应聚合物，热响应聚合物在人体温度下不能溶解于水，而在温度低于 30°C（最好低于 25°C）时可溶解于水。牺牲支架包括至少一根从入口延伸到出口的细丝，这样牺牲支架的溶解就提供了从入口到出口的液体通道。牺牲支架密封入口和/或出口，使牺牲支架在腔室中接收培养基质后溶解，通过培养基质形成从入口到出口的液体通道。
• Thermoresponsive cell culture supports
  申请人：Alghunaim Abdullah

  公开号：US11414645B2

  公开（公告）日：2022-08-16

  The present invention relates to a cell culture support comprising a substrate and a polymeric blend layer bound to the substrate. The polymeric blend layer comprises at least one thermoresponsive polymer and at least one coupling agent. The coupling agent is a non-protein coupling agent that has functional thiol, ester, epoxy, or aldehyde groups. The cell culture support further includes cells supported by the polymeric blend layer, wherein the thermoresponsive polymer provides for temperature induced detachment of the cells and/or cell sheets.

  本发明涉及一种细胞培养支架，包括基底和与基底结合的聚合物混合层。聚合物混合层包括至少一种热致伸缩性聚合物和至少一种偶联剂。偶联剂是一种非蛋白质偶联剂，具有硫醇、酯、环氧或醛等官能团。细胞培养支架还包括由聚合物混合物层支撑的细胞，其中热致伸缩性聚合物可使细胞和/或细胞薄片在温度诱导下脱离。
• Poly(2-cyclopropyl-2-oxazoline): From Rate Acceleration by Cyclopropyl to Thermoresponsive Properties
  作者：Meta M. Bloksma、Christine Weber、Igor Y. Perevyazko、Anette Kuse、Anja Baumgärtel、Antje Vollrath、Richard Hoogenboom、Ulrich S. Schubert

  DOI：10.1021/ma200514n

  日期：2011.6.14

  The synthesis and microwave-assisted living cationic ring-opening polymerization of 2-cyclopropyl-2-oxazoline is reported revealing the fastest polymerization for an aliphatic substituted 2-oxazoline to date, which is ascribed to the electron withdrawing effect of the cyclopropyl group. The poly(2-cyclopropyl-2-oxazoline) (pCPropOx) represents an alternative thermo-responsive poly(2-oxazoline) with a reversible critical temperature close to body temperature. The cloud point (CP) of the obtained pCPropOx in aqueous solution was evaluated in detail by turbidimetry, dynamic light scattering (DLS) and viscosity measurements. pCPropOx is amorphous with a significantly higher glass transition temperature (T(g) similar to 80 degrees C) compared to the amorphous poly(2-n-propyl-2-oxazoline) (pnPropOx) (T(g) similar to 40 degrees C), while poly(2-isopropyl-2-oxazoline) piPropOx is semicrystalline. In addition, a pCPropOx comb polymer was prepared by methacrylic acid end-capping of the living cationic species followed by RAFT polymerization of the macromonomer. The polymer architecture does not influence the concentration dependence of the CP, however, both the CP and T(g) of the comb polymer are lower due to the increased number of hydrophobic end groups.
• ODOR ADSORBENT COMPOSITION AND METHOD FOR USE IN POLYMERS
  申请人：MICROBAN PRODUCTS COMPANY

  公开号：EP3462874A1

  公开（公告）日：2019-04-10