2,2,4-trimethyl-2H-chromen-6-ol | 5331-20-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2,2,4-trimethyl-2H-chromen-6-ol
• 英文别名: 2,2,4-Trimethylchromen-6-ol
• CAS: 5331-20-4
• 化学式: C₁₂H₁₄O₂
• 分子量: 190.242
• InChiKey: WMPVYVYQUPPSNJ-UHFFFAOYSA-N

物化性质

• 熔点：
  104-105 °C
• 沸点：
  317.2±42.0 °C(Predicted)
• 密度：
  1.084±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2,4-trimethyl-2H-chromen-6-ol 在 甲醇 、 palladium on activated charcoal 作用下， 生成 2,2,4-Trimethyl-chroman-6-ol
  参考文献：
  名称：

  Bergel et al., Journal of the Chemical Society, 1938, p. 1375,1380

  摘要：

  DOI：
• 作为产物：
  描述：

  6-羟基-2,2-二甲基苯并二氢吡喃-4-酮 、 甲基氯化镁 在 盐酸 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 6.25h， 以76%的产率得到2,2,4-trimethyl-2H-chromen-6-ol
  参考文献：
  名称：

  [EN] NOVEL USE OF SUBSTITUTED 2H-CHROMENS AND THEIR DERIVATIVES
  [FR] NOUVELLE UTILISATION DES 2H-CHROMÈNES SUBSTITUÉS ET DE LEURS DÉRIVÉS

  摘要：

  本发明涉及使用2H-香豆素及其衍生物的公式(I)和/或公式(II)，其中R1和R2分别独立于H或C1-11-烷基或(CH2)n— OH，其中n为1至6之间的整数，或者R1和R2一起代表一个酮基，且其中R3、R4、R5和R6分别独立于H或C1-6-烷基或C1-6-烷氧基，R7为H或C1-6-烷基，作为抗氧化剂，特别是在饲料中，如宠物食品和饲料成分，如鱼粉、昆虫粉和禽畜粉，以及PUFA含量较高的油，如海洋油、微生物油、真菌油、藻类油和富含PUFA的植物油。本发明还涉及含有这些2H-香豆素及其衍生物的公式(I)和/或公式(II)的饲料成分和饲料，用于昆虫、水生动物和陆生动物。

  公开号：

  WO2019185898A1

文献信息

• NOVEL USE OF SUBSTITUTED 2H-CHROMENS AND THEIR DERIVATIVES
  申请人：DSM IP Assets B.V.

  公开号：EP3818136A1

  公开（公告）日：2021-05-12
• [EN] NEW FEED ADDITIVES OF FAT-SOLUBLE VITAMINS<br/>[FR] NOUVEAUX ADDITIFS ALIMENTAIRES DE VITAMINES LIPOSOLUBLES
  申请人：DSM IP ASSETS BV

  公开号：WO2021069752A1

  公开（公告）日：2021-04-15

  The present invention is directed to a feed additive comprising at least a fat- soluble vitamin and a process for its manufacture. Further objects of the present invention are feed comprising such feed additive, as well as methods for supplementation and corresponding uses of such feed additives and feed.
• [EN] NEW PROCESS FOR THE MANUFACTURE OF FEED ADDITIVES OF CAROTENOIDS<br/>[FR] NOUVEAU PROCÉDÉ DE FABRICATION D'ADDITIFS ALIMENTAIRES POUR ANIMAUX DE CAROTÉNOÏDES
  申请人：DSM IP ASSETS BV

  公开号：WO2021069753A1

  公开（公告）日：2021-04-15

  The present invention is directed to a specific process for the manufacture of a feed additive comprising at least a carotenoid and the feed additive itself. Further objects of the present invention are feed comprising such feed additive, as well as methods for pigmentation and corresponding uses of such feed additives and feed.
• [EN] NEW FEED ADDITIVES OF CAROTENOIDS<br/>[FR] NOUVEAUX ADDITIFS ALIMENTAIRES DE CAROTÉNOÏDES
  申请人：DSM IP ASSETS BV

  公开号：WO2021069733A1

  公开（公告）日：2021-04-15

  The present invention is directed to a feed additive comprising at least a carotenoid and a process for its manufacture. Further objects of the present invention are feed comprising such feed additive, as well as methods for pigmentation and corresponding uses of such feed additives and feed.
• [EN] MILK REPLACER COMPRISING ANIMAL-FREE FORMULATIONS OF FAT-SOLUBLE VITAMINS<br/>[FR] LAIT DE REMPLACEMENT COMPRENANT DES FORMULATIONS SANS MATIÈRE ANIMALE DE VITAMINES LIPOSOLUBLES
  申请人：[en]DSM IP ASSETS B.V.

  公开号：WO2022129433A1

  公开（公告）日：2022-06-23

  The present invention is directed to a milk replacer comprising an animal-free formulation comprising a) Vitamin A or a C1-20alkyl ester thereof and optionally vitamin D; b) Gum Arabic in an amount of ≤ 20 weight-%; c) at least one ingredient selected from modified food starches, starch hydrolysates, mono- and disaccharides; d) at least an antioxidant; e) an anti-caking agent; f) optionally an oil; g) optionally residual moisture; whereby all amounts a) to f) sum up to 100 weight-% and are based on the sum of the weight of a) to f), whereby the compound a) is encapsulated in a matrix formed by compounds b) and c). The present invention is further directed to said animal-free formulation, as well as its use in a milk replacer, especially for young non-human mammals such as calves, foals, young goats, young sheep and camel foals. Further objects of the present invention are processes for the manufacture of such animal-free formulations and such milk replacer.