2-十二烷基-2-甲基丙二酸 | 4474-61-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2-十二烷基-2-甲基丙二酸
• 英文名称: 3,3,N,N-Tetramethyl-2-butylamin
• 英文别名: (R)(S)-N,N-Dimethyl-pinacolylamin；dimethyl-(1,2,2-trimethyl-propyl)-amine；3-Dimethylamino-2.2-dimethyl-butan；Dimethyl-pinakolylamin；N,N,3,3-tetramethylbutan-2-amine
• CAS: 4474-61-7
• 化学式: C₈H₁₉N
• 分子量: 129.246
• InChiKey: QFRMBVRYAGBJIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-十二烷基-2-甲基丙二酸 在 hexafluorophosphoric acid 、 碳酸氢钠 作用下， 以 甲醇 、 水 为溶剂， 生成 [t-Bu(Me)CHNMe3]PF6
  参考文献：
  名称：

  Chiral Conducting Salts of Nickel Dithiolene Complexes

  摘要：

  Conducting and chiral [Ni(dmit)(2)] dithiolene salts were obtained by electrocrystallization of the radical [n-Bu4N][Ni(dmit)(2)] salt in the presence of chiral, enantiopure trimethylammonium cations. Three different cations were investigated, namely, (R)-Ph(Me)HC*-NMe3+, (S)-(Bu-t)(Me)HC*-NMe3+, and (S)-(1-Napht)MeHC*-NMe3+, noted (R)4, (S)-2, and (S)-3. Salts of 1:3 stoichiometry were obtained with (R)-1 and (S)-2, formulated as [(R)-1][Ni(dmit)(2)](3) and [(S)-2][Ni(dmit)(2)](3)center dot(CH3CN)(2). They both crystallize in the P2(1)2(1)2(1) chiral space group, with three crystallographically independent complexes exhibiting different oxidation degrees. Another salt with 2:5 stoichiometry was isolated with (S)-3. The semiconducting character of the three salts (sigma(RT) = 20-30 X 10(-3) S cm(-1)) finds its origin in a strong electron localization, favored by the large number of crystallographically independent [Ni(dmit)2] complexes in these chiral structures and their association into weakly interacting dimeric or trimeric motifs. Racemic salts with the same cations, obtained only with difficulties with the tert-butyl-containing (rac)-2 cation, afforded similar trimerized structures. The observed unusual stoichiometry and strong charge localization is tentatively assigned to the size and anisotropic charge distribution of the cations.

  DOI：

  10.1021/ic300146s
• 作为产物：
  描述：

  聚合甲醛 、 1,2,2-trimethylpropyl amine hydrochloride 在 palladium on activated charcoal 、 氢气 作用下， 以 水 为溶剂， 生成 2-十二烷基-2-甲基丙二酸
  参考文献：
  名称：

  Pracejus,H.; Winter,S., Chemische Berichte, 1964, vol. 97, p. 3173 - 3182

  摘要：

  DOI：

文献信息

• Catalyst-Free and Selective C–N Bond Functionalization: Stereospecific Three-Component Coupling of Amines, Dichloromethane, and >P(O)H Species Affording α-Aminophosphorus Compounds
  作者：Yalei Zhao、Xiuling Chen、Tieqiao Chen、Yongbo Zhou、Shuang-Feng Yin、Li-Biao Han

  DOI：10.1021/jo501961h

  日期：2015.1.2

  and selective C–N bond functionalization has been achieved through three-component coupling of amines, dihalomethane, and >P(O)H species. This reaction takes place stereospecifically with retention of configuration at phosphorus, which can produce various new optically active phosphorus analogues of α-amino acids.

  通过胺，二卤甲烷和> P（O）H物质的三组分偶联，实现了无催化剂和选择性C–N键的官能化。该反应立体定向地进行，并且保留了在磷处的构型，这可以产生各种新的α-氨基酸的旋光性磷类似物。
• HEPATITIS C VIRUS INHIBITORS
  申请人：LONG Daniel D.

  公开号：US20130115194A1

  公开（公告）日：2013-05-09

  The invention provides compounds of formula (I): wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are inhibitors of replication of the hepatitis C virus. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat hepatitis C viral infections, and processes and intermediates useful for preparing such compounds.

  这项发明提供了式(I)的化合物： 其中变量在规范中定义，或其药用盐，这些化合物是乙型肝炎病毒复制的抑制剂。该发明还提供了包括这些化合物的药物组合物，使用这些化合物治疗乙型肝炎病毒感染的方法，以及用于制备这些化合物的工艺和中间体。
• [EN] PROCESS FOR PREPARING DONEPEZIL HYDROCHLORIDE FORMS I AND III; AND AN INTERMEDIATE COMPOUND THEREOF<br/>[FR] PROCÉDÉ DE PRÉPARATION DES FORMES I ET III DU CHLORHYDRATE DE DONÉPÉZIL ET D'UN COMPOSÉ INTERMÉDIAIRE CORRESPONDANT
  申请人：CRISTÁLIA PRODUTOS QUÍMICOS FARMACÊUTICOS LTDA

  公开号：WO2015109377A1

  公开（公告）日：2015-07-30

  The present invention relates to a new efficient and industrially feasible process for the preparation of the commercial crystalline forms of donepezil hydrochloride Form I and III, with high purity and in a selective manner. This invention also relates to a new process for preparing an intermediate compound useful in the preparation of donepezil hydrochloride.

  本发明涉及一种新的高效和工业可行的过程，用于制备商业结晶形式的多奈哌齐盐酸盐I和III，具有高纯度和选择性。本发明还涉及一种用于制备多奈哌齐盐酸盐的中间化合物的新工艺。
• NOVEL SULFONE DERIVATIVES AND PROCESS FOR PRODUCING THESE
  申请人：SUMITOMO CHEMICAL COMPANY LIMITED

  公开号：EP1359143A1

  公开（公告）日：2003-11-05

  There are provided production processes for cyclic sulfone compounds of formula (2) or (4): or wherein the dashed lines represent that a double bond is present at one of three positions indicated; Ar and the wavy line are as defined below, characterized in that compounds of formula (1) or (3): or wherein Ar is aryl optionally having a substituent(s) and the wavy line represents either one of E/Z geometrical isomers or their mixture, is subjected to cyclization in the presence of an acid catalyst. These processes are excellent processes as the production processes for retinol from the viewpoints of raw material costs, intermediate purification, the number of steps, and the like.

  提供了化合物公式（2）或（4）的循环磺酮化合物的生产过程：其中虚线表示在所示的三个位置之一存在双键；Ar和波浪线如下所定义，其特征在于将化合物公式（1）或（3）：其中Ar是芳基，可以具有取代基，波浪线表示E/Z几何异构体之一或其混合物，在酸催化剂的存在下进行环化。这些过程是优秀的过程，从原材料成本、中间体纯化、步骤数量等方面来看，是维生素A生产过程的优秀替代方法。
• ELECTROLYTE FOR ELECTROLYTIC CAPACITOR, ELECTROLYTIC CAPACITOR AND PROCESS FOR PRODUCING TETRAFLUOROALUMINATE SALT OF ORGANIC ONIUM
  申请人：Takeda Masayuki

  公开号：US20070188977A1

  公开（公告）日：2007-08-16

  There are provided an aluminum electrolytic capacitor comprising an anode, a cathode comprising aluminum and an electrolytic solution containing an onium salt of fluorine-containing anion, wherein the electrolytic solution has a water concentration of 1% by weight or less, or wherein the cathode has a peak top of Al2p spectrum of 74.0 to 75.8 eV as measured by a method in which the surface of the cathode in the aluminum electrolytic capacitor heated at 125° C. for 50 hours is analyzed by X-ray photoelectron spectroscopy (XPS); an electrolytic solution for electrolytic capacitor comprising a quaternary cyclic amidinium tetrafluoroaluminate and a solvent and containing specific impurity compounds in a total amount of 0.6% by weight or less, and an electrolytic capacitor using the electrolytic solution; and a method for preparing an organic onium tetrafluoroaluminate which is advantageously used in an aluminum electrolytic capacitor.

  提供了一种铝电解电容器，包括阳极、含铝的阴极和含有含氟阴离子的有机盐电解液。其中，电解液的水浓度为重量的1%或更低，或者阴极具有Al2p光谱峰顶在74.0到75.8电子伏特之间的峰值，该峰值是通过将铝电解电容器中的阴极表面加热至125℃，并通过X射线光电子能谱（XPS）分析得出的。还提供了一种电解电容器用电解液，其中包括四元环酰胺铵四氟铝酸盐和溶剂，并且总杂质化合物的含量不超过重量的0.6%。此外，还提供了使用该电解液的电解电容器，以及制备有机盐四氟铝酸盐的方法，该方法在铝电解电容器中具有优势。