1,4,8,11-tetraazatetradecane

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,4,8,11-tetraazatetradecane
• 英文别名: N-(2-aminoethyl)-N'-[2-(propylamino)ethyl]propane-1,3-diamine
• 化学式: C₁₀H₂₆N₄
• 分子量: 202.343
• InChiKey: UGAHKAYVILJXGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  14
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  62.1
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,4,8,11-tetraazatetradecane 在 sodium tetrahydroborate 、 potassium carbonate 、 肼 作用下， 以 甲醇 、 水 、 乙腈 为溶剂， 反应 504.0h， 生成 2-(1,8-dibenzyl-4,11-(2-tert-butoxy-2-oxoethyl)-1,4,8,11-tetraazacyclotetradecan-6-yl)ethanol
  参考文献：
  名称：

  Methods for Preparing Functional Tetraazacycloalkane Compounds using a Specific Cyclic Bisaminal Compound

  摘要：

  具有以下化学式（I）或（II）的特殊C-官能化环状双胺化合物，它们的盐或溶剂合物，其制备方法，其用途，以及利用这些环状双胺化合物制备功能性四氮杂环烷化合物的方法。

  公开号：

  US20140323717A1
• 作为产物：
  描述：

  N,N'-二(2-氨乙基)-1,3-丙二胺 在 potassium carbonate 作用下， 以 乙醇 、 水 、 乙腈 为溶剂， 反应 10.0h， 生成 1,4,8,11-tetraazatetradecane
  参考文献：
  名称：

  通过双胺中间体对线性四胺进行强力 N-单烷基化

  摘要：

  通过两种线性四胺与乙二醛或丙酮醛缩合获得的二胺类用溴-或 α,ψ-二溴烷烃以良好的收率在仲氨基官能团之一处选择性烷基化以产生 N-单烷基化四胺或线性八胺。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

  DOI：

  10.1002/ejoc.200400459

文献信息

• RADIOACTIVE PROBE FOR DETECTING HYDROGEN SULFIDE
  申请人：Kyungpook National University Industry-Academic Cooperation Foundation

  公开号：EP3281643A2

  公开（公告）日：2018-02-14

  Provided is a probe for detecting in vivo hydrogen sulfide, specifically, a probe for detecting hydrogen sulfide including a complex compound into which a radioactive isotope Cu is introduced. According to specific embodiments of the present disclosure, as a result of real-time observing animal models, in which hydrogen sulfide involved in various diseases is generated in a large quantity, through optical and nuclear medicine imaging, the probe for detecting hydrogen sulfide according to the present disclosure may selectively bind with hydrogen sulfide to provide images of a site where hydrogen sulfide has abnormally increased in a cell or a tissue, thereby detecting a disease in an unexpected site without affecting the anatomical properties of the body. In addition, the probe for detecting hydrogen sulfide quickly reacts with hydrogen sulfide, thereby solving the existing problem of waiting a predetermined time for testing after an imaging agent is injected. Accordingly, the probe may be effectively used as a means for diagnosing diseases, such as a composition for imaging, an imaging method, etc.

  提供了一种用于检测体内硫化氢的探针，具体来说，是一种用于检测硫化氢的探针，其中包括引入了放射性同位素铜的复合物。根据本公开的具体实施例，通过实时观察动物模型，可以大量生成涉及各种疾病的硫化氢，通过光学和核医学成像，根据本公开的检测硫化氢的探针可以选择性地与硫化氢结合，提供细胞或组织中硫化氢异常增加的部位的图像，从而在不影响身体解剖特性的情况下检测意外部位的疾病。此外，用于检测硫化氢的探针与硫化氢迅速反应，从而解决了注射成像剂后等待预定时间进行测试的现有问题。因此，该探针可以有效用作诊断疾病的手段，如成像组合物、成像方法等。
• CONJUGATES MADE OF METAL COMPLEXES AND OLIGONUCLEOTIDES, AGENTS CONTAINING THE CONJUGATES, THEIR USE IN RADIODIAGNOSIS AS WELL AS PROCESS FOR THEIR PRODUCTION
  申请人：——

  公开号：US20020077306A1

  公开（公告）日：2002-06-20

  This invention relates to chemically modified oligo-nucleotide conjugates that contain a complexing agent or complex that is bound by a connecting component to the oligonucleotides. In this case, the oligonucleotides are modified in a way that prevents or at least significantly inhibits the degradation by naturally occurring nucleases. The oligonucleotide radical can bond specifically and with high bonding affinity to target structures and can thus produce a specific therapeutic or diagnostic effect by the bound complexing agent or complex.

  这项发明涉及化学修饰的寡核苷酸共轭物，其中包含一个由连接组分与寡核苷酸结合的络合剂或络合物。在这种情况下，寡核苷酸以一种方式进行了修饰，以防止或至少显著抑制天然核酸酶的降解。寡核苷酸基团可以与靶结构特异性地结合，并且可以通过结合的络合剂或络合物产生特异的治疗或诊断效果。
• Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them
  申请人：Platzek Johannes

  公开号：US20050118105A1

  公开（公告）日：2005-06-02

  Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.

  级联聚合物，含有复合配体，可选含有至少五个原子序数为21-29、39、42、44或57-83的元素离子，如果需要，还可以含有无机和/或有机碱、氨基酸或氨基酸酰胺阳离子，是用于诊断和治疗的有价值的络合物化合物和络合物。
• Novel antibodies
  申请人：Buchegger, Franz

  公开号：EP0323805A2

  公开（公告）日：1989-07-12

  The invention concerns novel monoclonal antibodies with high specificity to and affinity for human carcinoembryonic antigen (CEA), derivatives thereof, processes for the preparation of these antibodies and their derivatives, hybridoma cell lines secreting the antibodies, and processes for the preparation of said cell lines. The monoclonal antibodies of the invention and their derivatives are useful in the diagnosis and therapy of cancer and serial monitoring of cancer patients for recurrent disease or response to therapy. Test kits and pharmaceutical compositions containing said monoclonal anti-CEA antibodies are also subject of the invention.

  本发明涉及对人类癌胚抗原（CEA）具有高度特异性和亲和性的新型单克隆抗体、其衍生物、制备这些抗体及其衍生物的工艺、分泌这些抗体的杂交瘤细胞系以及制备上述细胞系的工艺。本发明的单克隆抗体及其衍生物可用于癌症的诊断和治疗，以及对癌症患者的复发疾病或治疗反应进行连续监测。含有所述单克隆抗 CEA 抗体的检测试剂盒和药物组合物也是本发明的主题。
• Novel chimeric antibodies
  申请人：CIBA-GEIGY AG

  公开号：EP0323806A1

  公开（公告）日：1989-07-12

  The invention relates to murine/human chimeric monoclonal antibodies with high specificity to and affinity for human carcinoembryonic antigen (CEA), derivatives thereof, processes for the preparation of these antibodies and their derivatives, DNAs coding for heavy and light chains of these antibodies, processes for the preparation of said DNAs, mammalian cell lines that produce and secrete the antibodies and processes for the preparation of said cell lines. The chimeric antibodies and their derivatives are used for clinical purposes in vitro and in vivo, especially for the diagnosis of cancer, for localization and in vivo imaging of tumors, for therapy, e.g. site-directed delivery of cytotoxins, and similar purposes. The invention also concerns test kits and pharmaceutical compositions containing said chimeric monoclonal antibodies and/or derivatives thereof.

  本发明涉及对人类癌胚抗原（CEA）具有高度特异性和亲和性的鼠/人嵌合单克隆抗体、其衍生物、制备这些抗体及其衍生物的工艺、编码这些抗体重链和轻链的DNA、制备所述DNA的工艺、产生和分泌抗体的哺乳动物细胞系以及制备所述细胞系的工艺。嵌合抗体及其衍生物可用于体外和体内的临床用途，特别是癌症诊断、肿瘤定位和体内成像、治疗（如细胞毒素的定点给药）以及类似用途。本发明还涉及含有所述嵌合单克隆抗体和/或其衍生物的检测试剂盒和药物组合物。