6-hydroxy-8-(2,3-dihydroxypropylthio)purine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 6-hydroxy-8-(2,3-dihydroxypropylthio)purine
• 英文别名: 6-Hydroxy-8-(2,3-dihydroxypropylthio)purine；8-(2,3-dihydroxypropylsulfanyl)-1,7-dihydropurin-6-one
• 化学式: C₈H₁₀N₄O₃S
• 分子量: 242.258
• InChiKey: OSXLQQFFBYJNPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  136
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  缩水甘油 、 1,7,8,9-四氢-8-硫氧代-6H-嘌呤-6-酮 以 氨 、 水 为溶剂， 以71%的产率得到6-hydroxy-8-(2,3-dihydroxypropylthio)purine
  参考文献：
  名称：

  Reactions of SH-Substituted Purine Bases with Glycidol

  摘要：

  The regioselectivity of S-alkylation of SH-substituted purine bases with glycidol tends to grow with decreasing temperature. A procedure was developed for epoxidation of these compounds in wet liquid ammonia. The products were tested for immunostimulating activity.

  DOI：

  10.1023/b:rugc.0000031869.41766.97

文献信息

• Reactions of SH-Substituted Purine Bases with Glycidol
  作者：S. I. Radchenko、E. V. Ratsino

  DOI：10.1023/b:rugc.0000031869.41766.97

  日期：2004.4

  The regioselectivity of S-alkylation of SH-substituted purine bases with glycidol tends to grow with decreasing temperature. A procedure was developed for epoxidation of these compounds in wet liquid ammonia. The products were tested for immunostimulating activity.