cyclohexyl-(4,4-dioxo-8-phenyl-7-oxa-4λ⁶-thia-5-azaspiro[2.5]oct-5-en-6-yl)amine | 1397342-18-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: cyclohexyl-(4,4-dioxo-8-phenyl-7-oxa-4λ⁶-thia-5-azaspiro[2.5]oct-5-en-6-yl)amine
• 英文别名: cyclohexyl-(4,4-dioxo-8-phenyl-7-oxa-4lambda*6*-thia-5-azaspiro[2.5]oct-5-en-6-yl)amine；cyclohexyl-(4,4-dioxo-8-phenyl-7-oxa-4lambda6-thia-5-azaspiro[2.5]oct-5-en-6-yl)amine；Cyclohexyl-(4,4-dioxo-8-phenyl-7-oxa-4lambda*6*-thia-5-azaspiro[2.5]oct-5-en-6-yl)amine；N-cyclohexyl-4,4-dioxo-8-phenyl-7-oxa-4λ6-thia-5-azaspiro[2.5]octan-6-imine
• CAS: 1397342-18-5
• 化学式: C₁₇H₂₂N₂O₃S
• 分子量: 334.439
• InChiKey: ZXLOPXNANONQOT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  76.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-tert-butyloxycarbonyl-1-(hydroxyphenylmethyl)cyclopropansulfonamide 在 盐酸 、 potassium tert-butylate 作用下， 以 N-甲基吡咯烷酮 、 水 、 乙酸乙酯 为溶剂， 反应 9.83h， 生成 cyclohexyl-(4,4-dioxo-8-phenyl-7-oxa-4λ⁶-thia-5-azaspiro[2.5]oct-5-en-6-yl)amine
  参考文献：
  名称：

  TETRASUBSTITUTED OXATHIAZINE DERIVATIVES, METHOD FOR PRODUCING THEM, THEIR USE AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND THE USE THEREOF

  摘要：

  该发明涉及式(I)的化合物以及其生理上可接受的盐。所述化合物适用于治疗高血糖等情况。

  公开号：

  US20140024584A1

文献信息

• DI- AND TRI-SUBSTITUTED OXATHIAZINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND USE THEREOF
  申请人：Boehme Thomas

  公开号：US20130345125A1

  公开（公告）日：2013-12-26

  The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.

  该发明涉及式(I)的化合物及其生理兼容盐。所述化合物适用于治疗高血糖，例如。
• DI AND TRI - SUBSTITUTED OXATHIAZINE DERIVATIVES, METHOD FOR THE PRODUCTION, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND USE THEREOF
  申请人：Boehme Thomas

  公开号：US20130338150A1

  公开（公告）日：2013-12-19

  The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.

  该发明涉及公式（I）的化合物及其生理兼容盐。这些化合物适用于治疗高血糖，例如。
• Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
  申请人：Boehme Thomas

  公开号：US08871758B2

  公开（公告）日：2014-10-28

  The invention relates to the compounds of formula (I) and to the physiologically acceptable salts thereof. Said compounds are suitable e.g. for the treatment of hyperglycemia.

  本发明涉及式(I)的化合物及其生理上可接受的盐。所述化合物适用于例如治疗高血糖等方面。
• Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
  申请人：Boehme Thomas

  公开号：US08710050B2

  公开（公告）日：2014-04-29

  The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.

  本发明涉及式(I)化合物及其生理相容盐。该化合物适用于治疗高血糖等疾病。
• Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
  申请人：Boehme Thomas

  公开号：US08828994B2

  公开（公告）日：2014-09-09

  The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.

  本发明涉及公式(I)的化合物及其生理相容盐。该化合物适用于治疗高血糖等疾病。