3-(2-羟基乙基)-2-甲基苯并噻唑鎓溴化物 | 63123-34-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 中文名称: 3-(2-羟基乙基)-2-甲基苯并噻唑鎓溴化物
• 英文名称: 3-(2-hydroxyethyl)-2-methylbenzothiazolium bromide
• 英文别名: 3-(2-Hydroxy-aethyl)-2-methyl-benzothiazolium-bromid；1-(2-hydroxyethyl)-2-methylbenzothiazolium bromide；Benzothiazolium, 3-(2-hydroxyethyl)-2-methyl-, bromide；2-(2-methyl-1,3-benzothiazol-3-ium-3-yl)ethanol;bromide
• CAS: 63123-34-2
• 化学式: Br*C₁₀H₁₂NOS
• 分子量: 274.181
• InChiKey: KMZBNPIZUBVKDQ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.51
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  52.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(2-羟基乙基)-2-甲基苯并噻唑鎓溴化物 在 劳森试剂 、 原甲酸三乙酯 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  荧光染料及其制备方法和应用

  摘要：

  本发明属于有机合成技术领域，具体涉及一种荧光染料及其制备方法和应用。所述荧光染料的结构通式如说明书中式I所示，其中，X和Y为相同或不同的O、S、C(CH3)2或NR6，R2和R3为相同或不同的氢或官能团，R1、R4、R5和R6均为官能团，Z－为负离子。该荧光染料具有活细胞膜通透性，可用于活细胞微结构荧光成像，同时可获取活细胞STED超分辨荧光成像及激光共聚焦等荧光成像。

  公开号：

  CN110128843B
• 作为产物：
  描述：

  2-甲基苯并噻唑 、 2-溴乙醇 反应 0.58h， 以58%的产率得到3-(2-羟基乙基)-2-甲基苯并噻唑鎓溴化物
  参考文献：
  名称：

  季铵盐的微波合成

  摘要：

  描述了几种季铵盐的微波合成。与已发表的方法相比，该合成提供了可比或更好的产率，同时缩短了反应时间，并且不存在溶剂。

  DOI：

  10.3390/molecules13092107

文献信息

• Symmetric Meso-Chloro-Substituted Pentamethine Cyanine Dyes Containing Benzothiazolyl/Benzoselenazolyl Chromophores Novel Synthetic Approach and Studies on Photophysical Properties upon Interaction with bio-Objects
  作者：Atanas Kurutos、Olga Ryzhova、Valeriya Trusova、Galyna Gorbenko、Nikolay Gadjev、Todor Deligeorgiev

  DOI：10.1007/s10895-015-1700-4

  日期：2016.1

  A series of symmetric pentamethine cyanine dyes derived from various N-substituted benzothiazolium/benzoselenazolium salts, and a conjugated bis-aniline derivative containing a chlorine atom at meso-position with respect to the polymethine chain, were synthesized using a novel improved synthetic approach under mild conditions at room temperature. The reaction procedure was held by grinding the starting

  一系列对称五甲花青染料从不同的N-取代的苯并噻唑鎓/ benzoselenazolium盐衍生的，并含有一个氯原子的共轭双苯胺衍生物内消旋，用一种新颖的合成位置相对于所述甲基链在温和改进的合成方法在室温条件下。通过将起始化合物研磨较短的时间来保持反应程序。该新颖方法是可靠的并且可重复性很高。使用Cy-5作为参考，在各种溶剂中记录了一些光物理特性，包括吸收和荧光量子产率。在目前的工作中，已经对与几种生物物体（如脂质体，DNA和蛋白质）相互作用的其他研究进行了研究。
• Asymmetric cyanine fluorescent dyes, compositions and their use in staining biological samples
  申请人：Shenzhen Mindray Bio-Medical Electronics Co., Ltd.

  公开号：US08067602B2

  公开（公告）日：2011-11-29

  Asymmetric cyanine fluorescent dyes are represented by general formula I. These kinds of dyes may be used as a staining agent for nucleic acids, with the spectra at 600-900 nm in the near-infrared region and without interference from background fluorescence. These kinds of dyes may be useful with small-type red semiconductor lasers as the light source (such as 633 nm). Compositions comprising these dyes and methods for staining biological samples using these dyes or compositions are also provided.

  非对称青光菁荧光染料由一般式I表示。这种染料可用作核酸染料，其光谱位于近红外区间的600-900 nm，并且不受背景荧光的干扰。这种染料可与小型红色半导体激光器一起使用作为光源（例如633 nm）。还提供了包含这些染料的组合物以及使用这些染料或组合物染色生物样本的方法。
• Asymmetric cyanine compounds, their preparation methods and their uses
  申请人：Shenzhen Mindray Bio-Medical Electronics Co. Ltd.

  公开号：US07709653B2

  公开（公告）日：2010-05-04

  Asymmetric cyanine compounds represented by general formula I are provided, wherein X, n, R1, R2, R3, R4 and Y− are as defined in the specification. They have a maximum absorption peak at about 640 nm which may not change with ambient temperature. When the compounds bind a nucleic acid to form a dye/nucleic acid complex, the fluorescence intensity of the complexes will increased rapidly, so that they can be used as a staining agent for nucleic acids in flow cytometers. Their spectra are in the near-infrared region, which can effectively reduce the interference from background fluorescence and improve the accuracy of detection. Moreover, the compounds provided can also be used as a staining agent for blood reticulocytes.

  提供了由一般式I表示的不对称青光菁化合物，其中X、n、R1、R2、R3、R4和Y-如规范中所定义。它们在大约640 nm处具有最大吸收峰，可能不随环境温度变化。当化合物与核酸结合形成染料/核酸复合物时，复合物的荧光强度将迅速增加，因此它们可以用作流式细胞仪中核酸的染色剂。它们的光谱位于近红外区域，可以有效减少背景荧光的干扰，提高检测的准确性。此外，提供的化合物还可用作血液网织红细胞的染色剂。
• Dyes and methods of detection of nucleic acid in immature red blood cells
  申请人：——

  公开号：US20020037589A1

  公开（公告）日：2002-03-28

  The dyes of the present invention are useful for many purposes that include markers or tags for detecting the presence of a molecule or compound to which they are bound. The dyes may be either red-excitable or blue-excitable. The dyes of the invention are particularly well suited for staining of nucleic acids. For example, these dyes are particularly suitable for staining of RNA in reticulocytes. In another exemplary application, these dyes are suitable for staining DNA in nucleated red blood cells. Typically, when used in staining of nucleic acids, the dyes are formulated into reagent solutions. In addition, the invention provides compositions and methods for facilitating rapid transport of dye molecules through a cell membrane. Such rapid staining requires that a sample be contacted with a dye composition of the invention in the presence of at least one surfactant and optionally, a sulfonic acid or a salt thereof.

  本发明的染料可用于许多目的，包括作为标记或标签，用于检测它们所结合的分子或化合物的存在。这些染料可以是红色激发的或蓝色激发的。本发明的染料特别适合用于染色核酸。例如，这些染料特别适合于染色网织红细胞中的RNA。在另一个示例应用中，这些染料适合于染色有核红细胞中的DNA。通常，在染色核酸时，这些染料被制成试剂溶液。此外，本发明提供了促进染料分子快速穿过细胞膜的组合物和方法。这种快速染色需要将样品与本发明的染料组合物接触，并在至少一种表面活性剂和可选的磺酸或其盐的存在下进行。
• ASYMMETRIC CYANINE COMPOUNDS, THEIR PREPARATION METHODS AND THEIR USES
  申请人：Jianhui Shao

  公开号：US20090305285A1

  公开（公告）日：2009-12-10

  Asymmetric cyanine compounds represented by general formula I are provided, wherein X, n, R 1 , R 2 , R 3 , R 4 and Y − are as defined in the specification. They have a maximum absorption peak at about 640 nm which may not change with ambient temperature. When the compounds bind a nucleic acid to form a dye/nucleic acid complex, the fluorescence intensity of the complexes will increased rapidly, so that they can be used as a staining agent for nucleic acids in flow cytometers. Their spectra are in the near-infrared region, which can effectively reduce the interference from background fluorescence and improve the accuracy of detection. Moreover, the compounds provided can also be used as a staining agent for blood reticulocytes.

  提供了由通式I表示的不对称青菁化合物，其中X、n、R1、R2、R3、R4和Y−如规范中定义。它们在约640 nm处具有最大吸收峰，该峰可能不随环境温度变化。当化合物与核酸结合形成染料/核酸复合物时，复合物的荧光强度将迅速增加，因此它们可以用作流式细胞仪中核酸的染色剂。它们的光谱位于近红外区域，可以有效减少背景荧光的干扰，提高检测的准确性。此外，所提供的化合物还可以用作血液网织红细胞的染色剂。