2-hydroxy-5-chlorobenzyl mercaptan | 118143-41-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-hydroxy-5-chlorobenzyl mercaptan
• 英文别名: 4-Chloro-2-(sulfanylmethyl)phenol
• CAS: 118143-41-2
• 化学式: C₇H₇ClOS
• 分子量: 174.651
• InChiKey: KXQUHGGFPOVHGK-UHFFFAOYSA-N

物化性质

• 沸点：
  295.5±25.0 °C(Predicted)
• 密度：
  1.341±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  21.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-hydroxy-5-chlorobenzyl mercaptan 以 甲醇 、 氯仿 为溶剂， 反应 25.5h， 生成 methyl (2R)-3-[(5-chloro-2-hydroxyphenyl)methyldisulfanyl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate
  参考文献：
  名称：

  Rational design of templates for intramolecular O,N-acyl transfer via medium-sized cyclic intermediates derived from L-cysteine. Definition of an experimental maximum in effective molarity through the study of "tunable" templates

  摘要：

  DOI：

  10.1021/jo00268a020
• 作为产物：
  描述：

  5-氯代水杨酸 在 吡啶 、 sodium hydrogensulfide 、 lithium aluminium tetrahydride 作用下， 以 甲醇 、 乙醚 为溶剂， 反应 4.75h， 生成 2-hydroxy-5-chlorobenzyl mercaptan
  参考文献：
  名称：

  Rational design of templates for intramolecular O,N-acyl transfer via medium-sized cyclic intermediates derived from L-cysteine. Definition of an experimental maximum in effective molarity through the study of "tunable" templates

  摘要：

  DOI：

  10.1021/jo00268a020

文献信息

• KEMP, D. S.;CAREY, ROBERT I.;DEWAN, JOHN C.;GALAKATOS, NICHOLAS G.;KERKMA+, J. ORG. CHEM., 54,(1989) N, C. 1589-1603
  作者：KEMP, D. S.、CAREY, ROBERT I.、DEWAN, JOHN C.、GALAKATOS, NICHOLAS G.、KERKMA+

  DOI：——

  日期：——
• GERMICIDAL TOPICAL COMPOSITIONS
  申请人：Guerra-Vega Sandra Judith

  公开号：US20120184626A1

  公开（公告）日：2012-07-19

  A topical germicidal composition comprising: 50-85% wt. of an alcohol constituent comprising one or more C1-C4 monohydric alcohols; 0.01-5% wt. of a film forming constituent based-on one or more celluloses or cellulose derivatives, 0.01-25% wt. of a humectant, preferably glycerine; 0.01-5% wt. of an opacifier constituent; optionally but preferably a Polyquaternium-type polymer or material; optionally one or more further constituents for improving the aesthetic or other technical characteristics of the invention, with the balance-of the composition, up to about 30% wt. of water, wherein the composition is characterized that it is flowable and preferably also exhibits an initial viscosity (“as mixed”) of at least about 10 cPs measured at 25° C., and subsequent to being stored at elevated temperatures and/or extended time intervals are retained as a single phase composition and do not split or separate into two or more phases, and further, the compositions provide a topical germicidal benefit when applied to the skin or parts of the body.
• AQUEOUS ALCOHOLIC MICROBICIDAL COMPOSITIONS COMPRISING ZINC IONS
  申请人：Reckitt Benckiser LLC

  公开号：US20150189888A1

  公开（公告）日：2015-07-09

  Compositions which impart a microbicidal benefit to treated surfaces which compositions comprise (or in certain preferred embodiments may consist essentially of, or may consist of): a zinc ion source material which releases zinc ions into the treatment composition, preferably a source of Zn ++ ions; preferably at least from about 20% wt. of at least one alcohol, which is preferably a lower alkyl monohydric alcohol) and water, optionally one or more further surfactants, further optionally one or more constituents which impart one or more advantageous technical or aesthetic benefits to the compositions, including one or more detersive surfactants; and water, wherein the composition has a pH of at least 4, preferably at least 5, wherein the surface treatment compositions, exhibit a microbicidal or germicidal or antimicrobial effect on treated inanimate surfaces, characterized in exhibiting a microbicidal benefit when tested against one or more challenge microorganisms, according to one or more of the following standardized test protocols: ASTM E1052 Standard Test Method for Efficacy of Antimicrobial Agents against Viruses in Suspension, or ASTM E1053 Standard Test Method to Assess Virucidal Activity of Chemicals Intended for Disinfection of Inanimate, Nonporous Environmental Surfaces, or European Standard Surface Test, EN13697, or AOAC Germicidal Spray Products as Disinfectant Test Method, AOAC Index. 17 th Ed. (2000, preferably against poliovirus type 1 (Sabin) (“PV1”)
• US9565858B2
  申请人：——

  公开号：US9565858B2

  公开（公告）日：2017-02-14
• Rational design of templates for intramolecular O,N-acyl transfer via medium-sized cyclic intermediates derived from L-cysteine. Definition of an experimental maximum in effective molarity through the study of "tunable" templates
  作者：Daniel S. Kemp、Robert I. Carey、John C. Dewan、Nicholas G. Galakatos、Daniel Kerkman、See Lap Leung

  DOI：10.1021/jo00268a020

  日期：1989.3