4,4'-dimethoxybenzoin α-oxime | 73172-43-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 4,4'-dimethoxybenzoin α-oxime
• 英文别名: 4,4'-dimethoxybenzoin oxime；p-anisoin oximes；anisoinoxime；Anisoin-oxime；2-hydroxyimino-1,2-bis(4-methoxyphenyl)ethanol
• CAS: 73172-43-7
• 化学式: C₁₆H₁₇NO₄
• 分子量: 287.315
• InChiKey: HOEFKWVMQYMLHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  71.3
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4,4'-dimethoxybenzoin α-oxime 在 palladium on activated charcoal L-酒石酸 、 氢气 作用下， 以 乙醇 为溶剂， 反应 12.0h， 生成 (-)-erythro-2-amino-1,2-dianisylethanol
  参考文献：
  名称：

  光学纯 (1R, 2S)- 和 (1S, 2R)-DI-p-甲氧基苯基氨基醇的制备

  摘要：

  摘要 分三步合成了外消旋二对甲氧基苯基氨基醇。通过重结晶获得光学纯的二对甲氧基苯基氨基醇。氨基醇的绝对构型通过 X 射线晶体学确定。

  DOI：

  10.1080/00397910008086985
• 作为产物：
  描述：

  茴香偶姻 在 sodium hydroxide 、 盐酸羟胺 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以99.7%的产率得到4,4'-dimethoxybenzoin α-oxime
  参考文献：
  名称：

  Optical Resolution of Fragrant Lactones

  摘要：

  Optical resolution of six chiral fragrant lactones (delta-jasmine lactone, massoia lactone, tuberolactone, pentynyllactone, delta-decalactone, and gamma-nonalactone) was investigated by means of either the diastereomeric salt formation method or the diastereomeric amide formation method. Using these procedures, we obtained each enantiomer from five of the six lactones, except for massoia lactone. All five lactones were obtained in a good yield and with high optical purity. Sensoric characteristics on both enantiomers and racemic modification of four lactones are given.

  DOI：

  10.3987/com-99-s149

文献信息

• A Convenient Synthetic Entry Into 2,2-Diorganyl-5,6-Diaryl-1,3,4,2-Dioxaza Silacyclohexene Derivatives VIA Dianion Cyclisation: Sequential One-Pot Cyclosylation
  作者：Maya Shankar Singh、Ganesh Pandey

  DOI：10.1080/00397910008087275

  日期：2000.10

  Abstract In a convenient one-pot sequence, treatment of bezoin and p-anisoin oximes with sodium hydride in dry THF in 1:2 molar ratio generates 1,5-dianion, which upon subsequent addition of diorganodichlorosilane yields 1,3,4,2-dioxazasilacyclohexene derivatives in good yields. In general, very often a salt elimination route is used for the synthesis of the title compounds.

  摘要 在方便的一锅法中，用氢化钠在无水 THF 中以 1:2 的摩尔比处理苯偶姻和对苯甲醚肟生成 1,5-二阴离子，随后加入二有机二氯硅烷后生成 1,3,4,2 -二恶氮杂硅杂环己烯衍生物，收率良好。通常，通常使用盐消除途径来合成标题化合物。
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Cu: MVol.B4, 151, page 1782 - 1784
  作者：

  DOI：——

  日期：——
• Feigl, F.; Sicher, G.; Singer, O., Chemische Berichte, 1925, vol. 58, p. 2294 - 2303
  作者：Feigl, F.、Sicher, G.、Singer, O.

  DOI：——

  日期：——
• Preparation of Optically Pure (1R, 2S)- and (1S, 2R)-DI-<i>p</i>-Methoxyphenyl Amino Alcohol
  作者：Jian Liao、Yili Zhang、Zhi Li、Daimo Chen、Albert S. C. Chan

  DOI：10.1080/00397910008086985

  日期：2000.9

  Abstract Racemic di-p-methoxyphenyl amino alcohol was synthesized in three steps. Optically pure di-p-methoxyphenyl amino alcohols were obtained by recrystallization. The absolute configuration of the amino alcohol was determined by X-ray crystallography.

  摘要 分三步合成了外消旋二对甲氧基苯基氨基醇。通过重结晶获得光学纯的二对甲氧基苯基氨基醇。氨基醇的绝对构型通过 X 射线晶体学确定。
• Optical Resolution of Fragrant Lactones
  作者：Hiroyuki Nohira、Keiko Mizuguchi、Toru Murata、Yuko Yazaki、Miho Kanazawa、Yoshio Aoki、Misako Nohira

  DOI：10.3987/com-99-s149

  日期：——

  Optical resolution of six chiral fragrant lactones (delta-jasmine lactone, massoia lactone, tuberolactone, pentynyllactone, delta-decalactone, and gamma-nonalactone) was investigated by means of either the diastereomeric salt formation method or the diastereomeric amide formation method. Using these procedures, we obtained each enantiomer from five of the six lactones, except for massoia lactone. All five lactones were obtained in a good yield and with high optical purity. Sensoric characteristics on both enantiomers and racemic modification of four lactones are given.