vinyl-phosphonic acid dibutyl ester | 682-76-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: vinyl-phosphonic acid dibutyl ester
• 英文别名: dibutyl vinylphosphonate；Vinyl-phosphonsaeure-dibutylester；Vinylphosphonsaeure-dibutylester；Dibutyl-vinyl-phosphite；Dibutyl ethenylphosphonate；1-[butoxy(ethenyl)phosphoryl]oxybutane
• CAS: 682-76-8
• 化学式: C₁₀H₂₁O₃P
• 分子量: 220.249
• InChiKey: WAHXDGYCAZAQPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  vinyl-phosphonic acid dibutyl ester 在 sodium 作用下， 以 乙醇 为溶剂， 反应 6.0h， 生成 N,N-bis[β-(dibutoxyphosphoryl)ethyl]-N-[β'-(2-methoxyphenoxy)ethyl]amine
  参考文献：
  名称：

  Two-fragment α-adrenolytics

  摘要：

  DOI：

  10.1007/bf02494649
• 作为产物：
  描述：

  三丁基,三丁酯 在 氢氧化钾 作用下， 生成 vinyl-phosphonic acid dibutyl ester
  参考文献：
  名称：

  Pudowik; Imaew, Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1952, p. 916,921; engl. Ausg. S. 813, 816

  摘要：

  DOI：

文献信息

• [EN] LIPOPHOSPHONOXINS, THEIR PREPARATION AND USE<br/>[FR] LIPOPHOSPHONOXINES, LEUR PRÉPARATION ET LEUR UTILISATION
  申请人：USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR V V I

  公开号：WO2021115503A1

  公开（公告）日：2021-06-17

  Described herein are lipophosphonoxins of general formula I, diastereomers and mixtures of diastereomers of compounds of general formula I and their pharmaceutically acceptable salts and hydrates as antibacterial agents, forming an active ingredient in pharmaceutical compositions for the treatment of resistant bacterial infections, disinfectants and/or selective culture media.

  本文描述了一般式I的脂磷酰氧杂环己烷类化合物，以及一般式I化合物的对映体和对映体混合物，它们的药学上可接受的盐和水合物作为抗菌剂，构成用于治疗耐药细菌感染、消毒剂和/或选择性培养基的药物组合物中的活性成分。
• ORGANOPHOSPHORUS COMPOUND AND FLAME RETARDANT AGENT COMPRISING SAME, AND METHOD FOR PRODUCING ORGANOPHOSPHORUS COMPOUND
  申请人：Maruzen Petrochemical Co., Ltd.

  公开号：US20200270288A1

  公开（公告）日：2020-08-27

  An object is to provide a novel organophosphorus compound which can impart flame retardancy to an amorphous resin in a smaller addition amount without deteriorating heat resistance and transparency, and also can be applied to a wide range of resins, a flame retardant containing the same, and a method for producing an organophosphorus compound. An organophosphorus compound represented by the following general formula (1) (wherein R 1 and R 2 are independently hydrogen, an alkyl group having 1 to 15 carbon atoms, an aryl group having 6 to 12 carbon atoms, an aralkyl group having 7 to 15 carbon atoms, or an alkylaryl group having 7 to 15 carbon atoms, R 3 and R 4 are independently an alkyl group having 1 to 15 carbon atoms, an aryl group having 6 to 12 carbon atoms, an aralkyl group having 7 to 15 carbon atoms, an alkylaryl group having 7 to 15 carbon atoms, an alkoxy group having 1 to 15 carbon atoms, an aryloxy group having 6 to 12 carbon atoms, an aralkyloxy group having 7 to 15 carbon atoms, or an alkylaryloxy group having 7 to 15 carbon atoms, provided that R 3 and R 4 may be bound to each other to form a ring, and m and n are independently 1, 2, 3 or 4), a flame retardant containing the same, and a method for producing an organophosphorus compound.

  提供一种新型有机磷化合物，可以在较小的添加量下赋予无定形树脂阻燃性能，而不会降低耐热性和透明性，同时也可以应用于广泛范围的树脂中，包括含有相同化合物的阻燃剂，以及一种生产有机磷化合物的方法。所述有机磷化合物由以下通用式(1)表示（其中R1和R2分别为氢、具有1至15个碳原子的烷基基团、具有6至12个碳原子的芳基基团、具有7至15个碳原子的芳基烷基基团或具有7至15个碳原子的烷基芳基基团，R3和R4分别为具有1至15个碳原子的烷基基团、具有6至12个碳原子的芳基基团、具有7至15个碳原子的芳基烷基基团、具有7至15个碳原子的烷基芳基基团、具有1至15个碳原子的烷氧基、具有6至12个碳原子的芳氧基、具有7至15个碳原子的芳基烷氧基或具有7至15个碳原子的烷基芳氧基，其中R3和R4可以结合形成环，m和n分别为1、2、3或4），包含相同化合物的阻燃剂，以及一种生产有机磷化合物的方法。
• Synthesis of β-Aminophosphonates and Study of Their Acid-Base Properties and Phase Distribution in Water-Organic Solvent Systems
  作者：R. A. Cherkasov、V. I. Galkin、N. G. Khusainova、O. A. Mostovaya、A. R. Garifzyanov、G. Kh. Nuriazdanova、N. S. Krasnova、E. A. Berdnikov

  DOI：10.1007/s11178-005-0370-0

  日期：2005.10

  New and previously known β-aminoethylphosphonates were synthesized by addition of primary and secondary amines to vinylphosphonates, and their IR and NMR spectra were examined. Diethyl 2-diethylaminoethylphosphonate and diethyl 2-morpholinoethylphosphonate were found to be stronger bases than the corresponding aminomethylphosphonates, but all these are weaker bases than their precursors, nonphosphorylated amines. Distribution constants of β-aminophosphonates between water and some organic solvents were determined and compared with those of their α-amino homologs.

  通过在乙烯基膦酸盐中加入伯胺和仲胺，合成了新的β-氨基乙基膦酸盐和以前已知的β-氨基乙基膦酸盐，并研究了它们的红外光谱和核磁共振光谱。研究发现，2-二乙氨基乙基膦酸二乙酯和 2-吗啉基乙基膦酸二乙酯是比相应的氨基甲基膦酸盐更强的碱，但所有这些碱都比它们的前体--非磷酸化胺弱。测定了 β-氨基膦酸盐在水和一些有机溶剂中的分布常数，并将其与α-氨基同系物的分布常数进行了比较。
• PROCESS FOR PREPARING AN ALKENYLPHOSPHONIC ACID DERIVATIVE
  申请人：Biel Markus Christian

  公开号：US20100121092A1

  公开（公告）日：2010-05-13

  Process for preparing an alkenylphosphonic acid derivative by reacting a phosphonic acid derivative with an alkyne in the presence of a complex catalyst system and a base whose conjugate acid has a pKa in dimethyl sulfoxide (25° C., 1 bar) of at least 6.

  在复合催化剂系统和碱的存在下，通过将磷酸衍生物与炔烃反应制备烯基膦酸衍生物的过程，并且该碱的共轭酸在二甲基亚砜（25°C，1巴）中的pKa至少为6。
• METHOD FOR PRODUCING ALKENYL PHOSPHORUS COMPOUND
  申请人：MARUZEN PETROCHEMICAL CO., LTD.

  公开号：US20190263847A1

  公开（公告）日：2019-08-29

  Provided is a method for producing an alkenyl phosphorus compound which can produce an alkenyl phosphorus compound efficiently even with a smaller amount of a catalyst used than that used conventionally, and further which can maintain catalytic activity to produce an alkenyl phosphorus compound in high yield even at a larger reaction scale, and which can also be applied to quantity synthesis at an industrial scale using a conventional batch reactor or continuous reactor. A method for producing an alkenyl phosphorus compound, comprising: a step of reacting a compound represented by the following formula (1): [In formula (1), R 1 represents OR 3 or R 3 , R 2 represents OR 4 or R 4 , and R 3 and R 4 represent, for example, each independently a substituted or unsubstituted alkyl group.] with a compound represented by the following formula (2): R 5 —C≡CH  (2) [In formula (2), R 5 represents, for example, a hydrogen atom, or a substituted or unsubstituted alkyl group.] to produce the phosphorus alkenyl compound presented by at least any of the following formulas (3a) or (3b): [In formulas (3a) and (3b), R 1 and R 2 have the same meaning as defined in formula (1), and R 5 has the same meaning as defined in formula (2).], In which the compound represented by formula (1) is reacted with the compound represented by formula (2) using a transition metal catalyst, and a phosphorus oxo acid compound having an intramolecular P—H bond.

  提供的是一种生产烯基磷化合物的方法，该方法即使使用的催化剂量比传统方法少，也能高效地生产烯基磷化合物，而且能够在更大的反应规模下保持催化活性，以高收率生产烯基磷化合物，并且还可以在传统的批量反应器或连续反应器中进行工业规模的量产合成。 生产烯基磷化合物的方法包括以下步骤： 将以下式（1）所表示的化合物与以下式（2）所表示的化合物反应： 式（1）中，R1代表OR3或R3，R2代表OR4或R4，R3和R4例如各自独立地代表取代或未取代的烷基基团。 式（2）中，R5例如代表氢原子，或代表取代或未取代的烷基基团。 从而产生至少以下任一式（3a）或（3b）所表示的磷烯烃化合物： 式（3a）和（3b）中，R1和R2的含义与式（1）中定义的相同，R5的含义与式（2）中定义的相同。 其中，使用过渡金属催化剂和具有分子内P-H键的磷氧酸化合物使式（1）所表示的化合物与式（2）所表示的化合物反应。