1-烯丙基-3-(3-氯苯基)脲 | 128720-23-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-烯丙基-3-(3-氯苯基)脲
• 英文名称: 1-allyl-3-(3-chlorophenyl)urea
• 英文别名: 1-(3-chlorophenyl)-3-prop-2-enylurea
• CAS: 128720-23-0
• 化学式: C₁₀H₁₁ClN₂O
• mdl: MFCD00018407
• 分子量: 210.663
• InChiKey: ITFLIVVAIKVBLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-Allyl-3-(3-chloro-phenyl)-thiourea 在 phosphate buffer 作用下， 以 乙醇 为溶剂， 以81%的产率得到1-烯丙基-3-(3-氯苯基)脲
  参考文献：
  名称：

  Kamal, Ahmed; Rao, Maddamsetty V.; Rao, Adari B., Chemistry Letters, 1990, # 4, p. 655 - 656

  摘要：

  DOI：

文献信息

• Iron(iii) catalysed synthesis of unsymmetrical di and trisubstituted ureas – a variation of classical Ritter reaction
  作者：Hosamani Basavaprabhu、Vommina V. Sureshbabu

  DOI：10.1039/c2ob06916d

  日期：——

  An application of the classical Ritter reaction for the synthesis of unsymmetrical di and trisubstituted ureas catalyzed by FeCl3 is described. The protocol is of significant interest in view of the easy availability of precursors, mild reaction conditions employed and interestingly its applicability for the alkylation of alcohols capable of forming stable carbocationic intermediates even to the sterically hindered moieties.

  介绍了利用经典Ritter反应合成非对称二取代和三取代脲类化合物的方法，该反应由FeCl3催化。该方案具有重要意义，因为其前体易于获得，反应条件温和，而且在对能够形成稳定碳正离子中间体的醇进行烷基化时，即使是空间位阻较大的基团也能适用。
• An efficient transformation of ethers to N,N′-disubstituted ureas in a Ritter type reaction
  作者：Veladi Panduranga、Basavaprabhu、Vommina V. Sureshbabu

  DOI：10.1016/j.tetlet.2012.12.027

  日期：2013.2

  A simple, mild, and an alternative protocol for the preparation of N,N'-disubstituted ureas from readily available ethers and cyanamides as starting materials is described. The protocol explores the reactivity of ether in a Ritter type reaction with cyanamide in the presence of BF3 center dot Et2O and resulting in the formation of N,N'-disubstituted urea. Divinyl ether as well as MTBE (methyl tert-butyl ether) can be employed as ether components to afford allyl and tert-butyl ureas respectively. (C) 2012 Elsevier Ltd. All rights reserved.
• KAMAL, AHMED;RAO, MADDAMSETTY V.;RAO, ADARI B., CHEM. LETT.,(1990) N, C. 655-656
  作者：KAMAL, AHMED、RAO, MADDAMSETTY V.、RAO, ADARI B.

  DOI：——

  日期：——
• Kamal, Ahmed; Rao, Maddamsetty V.; Rao, Adari B., Chemistry Letters, 1990, # 4, p. 655 - 656
  作者：Kamal, Ahmed、Rao, Maddamsetty V.、Rao, Adari B.

  DOI：——

  日期：——