di-tert-butyl 1-methylhydrazine-1,2-dicarboxylate | 202980-96-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: di-tert-butyl 1-methylhydrazine-1,2-dicarboxylate
• 英文别名: N'-[(Tert-butoxy)carbonyl]-N-methyl(tert-butoxy)carbohydrazide；tert-butyl N-methyl-N-[(2-methylpropan-2-yl)oxycarbonylamino]carbamate
• CAS: 202980-96-9
• 化学式: C₁₁H₂₂N₂O₄
• 分子量: 246.307
• InChiKey: RNBDCZHGBRYMFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  di-tert-butyl 1-methylhydrazine-1,2-dicarboxylate 在 吡啶 、 4-二甲氨基吡啶 、 magnesium(II) perchlorate 作用下， 以 乙腈 为溶剂， 反应 133.5h， 生成 tert-butyl 2-acetyl-1-methylhydrazinecarboxylate
  参考文献：
  名称：

  Combination of tert-Butoxycarbonyl and Triphenylphosphonium Protecting Groups in the Synthesis of Substituted Hydrazines

  摘要：

  [GRAPHICS]A new reagent for the systematic synthesis of substituted hydrazines is reported. Unlike previously developed reagents, this one contains only two protecting groups, thus providing a faster approach to multisubstituted derivatives. The selective introduction of alkyl and acyl groups is illustrated by a few examples, Also a new fast method for the deprotection of the triphenylphosphonium group is presented.

  DOI：

  10.1021/ol0160856
• 作为产物：
  描述：

  1,1,2-肼三羧酸三叔丁酯 在 sodium hydroxide 、 magnesium(II) perchlorate 、 四丁基硫酸氢铵 、 potassium carbonate 作用下， 以 甲苯 、 乙腈 为溶剂， 反应 1.5h， 生成 di-tert-butyl 1-methylhydrazine-1,2-dicarboxylate
  参考文献：
  名称：

  Combination of tert-Butoxycarbonyl and Triphenylphosphonium Protecting Groups in the Synthesis of Substituted Hydrazines

  摘要：

  [GRAPHICS]A new reagent for the systematic synthesis of substituted hydrazines is reported. Unlike previously developed reagents, this one contains only two protecting groups, thus providing a faster approach to multisubstituted derivatives. The selective introduction of alkyl and acyl groups is illustrated by a few examples, Also a new fast method for the deprotection of the triphenylphosphonium group is presented.

  DOI：

  10.1021/ol0160856

文献信息

• SUBSTITUTED 1-(THIAZOLYL)-AND 1-(ISOTHIAZOLYL)PYRAZOL-4-YLACETIC ACIDS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES AND PLANT GROWTH REGULATORS
  申请人：Martelletti Arianna

  公开号：US20100197501A1

  公开（公告）日：2010-08-05

  The invention relates to 1-(thiazolyl)- and 1-(isothiazolyl)pyrazol-4-ylacetic acid derivatives of the general formula (I) and salts thereof in which Het, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and n are as defined in claim 1. The compounds (I) or salts thereof are suitable for use as herbicides and plant growth regulators, in particular as herbicides for the selective control of harmful plants in crops of useful plants and can be prepared by processes as described in claim 9.

  这项发明涉及一般式(I)的1-(噻唑基)-和1-(异噻唑基)吡唑-4-基乙酸衍生物及其盐，其中Het，R1，R2，R3，R4，R5，R6和n如权利要求1所定义。化合物(I)或其盐适用于用作除草剂和植物生长调节剂，特别是作为对有用植物作物中有害植物的选择性控制除草剂，并且可以通过权利要求9中描述的方法制备。
• SUBSTITUTED 1-(DIAZINYL)PYRAZOL-4-YLACETIC ACIDS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES AND PLANT GROWTH REGULATORS
  申请人：JAKOBI Harald

  公开号：US20100160164A1

  公开（公告）日：2010-06-24

  The invention relates to 1-(3-diazinyl)pyrazol-4-ylacetic acid derivatives of the general formula (I) and salts thereof in which Het, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and n are as defined in the specification. The compounds (I) and their salts are suitable as herbicides and plant growth regulators, in particular as herbicides for the selctive control of harmful plants in crops of useful plants, and can be prepared by processes as described in the specification.

  这项发明涉及一般式(I)的1-(3-二嗪基)吡唑-4-基乙酸衍生物及其盐，其中Het、R1、R2、R3、R4、R5、R6和n如规范中所定义。化合物(I)及其盐适用作除草剂和植物生长调节剂，特别是作为对有用植物作物中有害植物的选择性控制除草剂，并可通过规范中描述的方法制备。
• Alkylation Reactions of Azodicarboxylate Esters with 4-Alkyl-1,4-Dihydropyridines under Catalyst-Free Conditions
  作者：Kazunari Nakajima、Yulin Zhang、Yoshiaki Nishibayashi

  DOI：10.1021/acs.orglett.9b01537

  日期：2019.6.21

  Introduction of alkyl groups on azodicarboxylate esters is an important method to prepare alkyl amine derivatives. Herein, we report reactions of 4-alkyl-1,4-dihydropyridines as alkylation reagents with di-tert-butyl azodicarboxylate to prepare alkyl amine derivatives under heating conditions. The alkylation reactions via C–C bond cleavage of the dihydropyridines are achieved in the absence of catalysts

  在偶氮二羧酸酯上引入烷基是制备烷基胺衍生物的重要方法。本文中，我们报道了在加热条件下，作为烷基化试剂的4-烷基-1,4-二氢吡啶与偶氮二羧酸二叔丁酯的反应，以制备烷基胺衍生物。在没有催化剂和添加剂的情况下，通过二氢吡啶的CC键断裂进行的烷基化反应得以实现。
• Highly homogeneous antibody modification through optimisation of the synthesis and conjugation of functionalised dibromopyridazinediones
  作者：Calise Bahou、Daniel A. Richards、Antoine Maruani、Elizabeth A. Love、Faiza Javaid、Stephen Caddick、James R. Baker、Vijay Chudasama

  DOI：10.1039/c7ob03138f

  日期：——

  reagents, particularly in the field of antibody conjugation. Despite this, relatively little work has been performed on the optimisation of their synthesis and subsequent reaction with immunoglobulins. Herein we present a novel synthetic route towards functionalised dibromopyridazinediones, proceeding via an isolatable dibromopyridazinedione-NHS ester. Reaction of this activated intermediate with a variety

  由于其出色的半胱氨酸选择性，出色的稳定性以及功能性重结合二硫键的能力，二溴哒嗪二酮正在成为令人兴奋的新型生物偶联试剂，特别是在抗体偶联领域。尽管如此，在优化它们的合成以及随后与免疫球蛋白的反应方面进行的工作相对较少。在这里，我们提出了一种新的合成途径，向功能化的二溴哒嗪二酮，通过一种可分离的二溴哒嗪二酮-NHS酯。该活化的中间体与多种胺的反应产生功能良好的二溴代哒嗪二酮，产率高至优异。在临床上相关的IgG1曲妥珠单抗上优化了这些试剂的二硫键再杂交能力，从而产生了一种通用方法，该方法可以生成具有90％以上同质性（无需二硫键加扰）的位点选择性修饰的天然曲妥珠单抗，而无需进行蛋白质工程或酶结合。
• Preparation of Multiply Protected Alkylhydrazine Derivatives by Mitsunobu and PTC Approaches
  作者：Nicolas Brosse、Maria-Fatima Pinto、Brigitte Jamart-Grégoire

  DOI：10.1002/ejoc.200300445

  日期：2003.12

  Alkylation reactions of hydrazine derivatives by Mitsunobu or PTC approaches are described. It has been shown that aminophthalimide derivatives are better acidic partners than their aminoimidodicarbonate (NBoc2) analogues, the presence of the phthaloyl group increasing the acidity of the sole proton and concomitantly reducing steric hindrance. Moreover, N-aminophthalimide derivatives can be efficiently

  描述了通过 Mitsunobu 或 PTC 方法对肼衍生物进行烷基化反应。已经表明，氨基邻苯二甲酰亚胺衍生物是比它们的氨基亚氨基二碳酸酯 (NBoc2) 类似物更好的酸性伙伴，邻苯二甲酰基的存在增加了唯一质子的酸度并同时减少了空间位阻。此外，N-氨基邻苯二甲酰亚胺衍生物可以在非常温和的条件下通过三阶段、一瓶程序有效地转化为相应的 N-氨基-亚胺二碳酸酯。这些程序也可以有效地用于制备正交 Nα,Nβ-diprotected α-肼酯。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)